A5022453936- Genetics, Aging, and Longevity in Model Organisms
- Fungal and yeast genetics research
- Cardiac, Anesthesia and Surgical Outcomes
- Microbial Metabolic Engineering and Bioproduction
- Fatty Acid Research and Health
- GABA and Rice Research
- Advanced X-ray and CT Imaging
- DNA Repair Mechanisms
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Methane Hydrates and Related Phenomena
- Catalytic Alkyne Reactions
- Dietary Effects on Health
- Diet and metabolism studies
- Retinal Diseases and Treatments
- Obstructive Sleep Apnea Research
- Evolution and Genetic Dynamics
- Eicosanoids and Hypertension Pharmacology
- Cardiac Imaging and Diagnostics
- Malaria Research and Control
- Invertebrate Immune Response Mechanisms
- Infection Control and Ventilation
- Aging and Gerontology Research
New York University
2010-2025
University of Washington
2015-2024
UNSW Sydney
2023-2024
St Vincent's Hospital Sydney
2024
Center for Infectious Disease Research
2024
University of Southern California
2020-2023
Prince of Wales Hospital
2017-2023
NYU Langone Health
2023
KWJ Engineering (United States)
2021
Seattle University
2021
Selection of microorganisms in marine sediment is shaped by energy-yielding electron acceptors for respiration that are depleted vertical succession. However, some taxa have been reported to reflect past depositional conditions suggesting they experienced weak selection after burial. In sediments underlying the Arabian Sea oxygen minimum zone (OMZ), we performed first metagenomic profiling sedimentary DNA at centennial-scale resolution context a multi-proxy paleoclimate reconstruction. While...
BackgroundExcessive sleepiness (ES) is a common symptom of OSA, which often persists despite primary OSA therapy. This phase III randomized withdrawal trial evaluated solriamfetol (JZP-110) for the treatment ES in adults with OSA.MethodsAfter 2 weeks clinical titration (n = 174) and stable dose administration 148), participants who reported improvement on Patient Global Impression Change (PGI-C) had numerical improvements Maintenance Wakefulness Test (MWT) Epworth Sleepiness Scale (ESS) were...
Docosahexaenoic acid (DHA), eicosapentaenoic (EPA), and arachidonic (AA) play key roles in several metabolic processes relevant to Alzheimer's disease (AD) pathogenesis neuroinflammation. Carrying the APOEɛ4 allele (APOE4) accelerates omega-3 polyunsaturated fatty (PUFA) oxidation. In a pre-planned subgroup analysis of Disease Cooperative Study-sponsored DHA clinical trial, APOE4 carriers with mild probable AD had no improvements cognitive outcomes compared placebo, while APOE 4 non-carriers...
The yeast genome becomes unstable during stress, which often results in adaptive aneuploidy, allowing rapid activation of protective mechanisms that restore cellular homeostasis. In this study, we performed a genetic screen Saccharomyces cerevisiae to identify adaptations confer resistance tunicamycin-induced endoplasmic reticulum (ER) stress. Whole-genome sequencing tunicamycin-resistant mutants revealed ER stress correlated significantly with gains chromosomes II and XIII. We found...
To understand the genetic basis and selective forces acting on longevity, it is useful to examine lifespan variation among closely related species, or ecologically diverse isolates of same within a controlled environment. In particular, this approach may lead understanding mechanisms underlying natural in lifespan. Here, we analyzed 76 wild yeast discovered wide diversity replicative (RLS). Phylogenetic analyses pointed genes environmental factors that strongly interact modulate observed...
Abstract We have developed a catalytic method for the hydroalkylation of allenes using alkyl triflates as electrophiles and silane hydride source. The reaction has an excellent substrate scope is compatible with wide range functional groups, including esters, aryl halides, boronic sulfonamides, tosylates, bromides. found evidence mechanism that involves unusual dinuclear copper ally complexes intermediates. structure these provides rationale their unexpected reactivity.
Preoperative cardiovascular risk stratification before noncardiac surgery is a common clinical challenge. Coronary artery calcium scores from ECG-gated chest computed tomography (CT) imaging are associated with perioperative events. At the time of preoperative evaluation, many patients will not have had CT imaging, but nongated studies performed for variety indications. We evaluated relationships between coronary severity estimated previous and major events (MCE) after surgery.
Global development organizations rely on the essential affordances provided by both paper and digital materials to navigate hurdles posed poor infrastructure, low connectivity, linguistic differences, other socioeconomic constraints that render communication collaboration challenging. This examines collaborative practices around paper-digital workflows within global operating in low-resource environments. We use a mixed methods approach gather data from 23 16 countries. Our findings show...
Apolipoprotein ε allele 4 (APOE4) influences the metabolism of polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acid (DHA). The entorhinal cortex (EC) in brain is affected early Alzheimer's disease and rich DHA. purpose this study to identify effect APOE4 DHA lipid species on EC. Plasma cerebrospinal fluid (CSF) lipidomic measurements were obtained from Brain Delivery Pilot, a randomized clinical trial supplementation (n = 10) versus placebo 12) for six months nondemented older...
The budding yeast has served as a useful model organism in aging studies, leading to the identification of genetic determinants longevity, many which are conserved higher eukaryotes. However, factors that promote longevity laboratory setting often have severe fitness disadvantage wild. Here, obtain an unbiased view on regulation we analyzed how replicative lifespan is shaped by transcriptional, translational, metabolic, and morphological across 22 wild-type Saccharomyces cerevisiae isolates....
Translational geroscience is an interdisciplinary field descended from basic gerontology that seeks to identify, validate, and clinically apply interventions maximize healthy, disease-free lifespan. In this review, we describe a research pipeline for the identification validation of lifespan extending interventions. Beginning in invertebrate model systems, are discovered then characterized using other systems (evolutionary translation), models genetic diversity, disease models. Vertebrate...
Abstract The progress made in aging research using laboratory organisms is undeniable. Yet, with few exceptions, these studies are conducted a limited number of isogenic strains. path from discoveries to treatment human populations complicated by the reality genetic variation nature. To model effect on action drug rapamycin, here we use growth Drosophila melanogaster larvae. We screened 140 lines Genetic References Panel for extent developmental delay and found wide‐ranging their response,...
Eosinophilic esophagitis (EE) is a motility disorder of the esophagus that typically presents with dysphagia. The objective present study was to explore patient characteristics, clinical and endoscopic features, response treatment patients EE. Patients were selected retrospectively based on review biopsy results from previous endoscopies performed between 2004 2008. A total 54 (41 men 13 women) biopsy-proven EE included in study. Further information regarding patients' obtained through chart...
Acute blood pressure (BP) elevations in neurosurgical patients are associated with serious neurologic, cardiovascular, or surgical site complications. Clevidipine, an ultra-short-acting dihydropyridine calcium antagonist, has been shown to be efficacious and safe for acute hypertension cardiac surgery. This study assessed the efficacy safety of clevidipine controlling perioperative setting.Patients scheduled intracranial surgery were prospectively enrolled after giving consent. Clevidipine...
Significance Mutations accumulate throughout life in every cell of the body. A long-standing question is to what extent these mutations contribute aging. Age single greatest risk factor for cancer, a disease driven by random mutagenesis and selection malignant phenotypes. We wondered whether cancer cells, being most heavily mutagenized human cell, are short-lived due mutagenesis. Single-cell measurements replicative lifespan not established cells. So, instead, we engineered diploid yeast...
Purpose: Multiple myeloma is an insidious haematological malignancy characterised by monoclonal proliferation of plasma cells in the bone marrow. Extramedullary plasmacytoma a rare manifestation multiple and usually occurs upper respiratory tract. Orbital involvement particularly uncommon, but may be associated with devastating visual impairment poor clinical outcomes. Therefore, this article aims to highlight need for multidisciplinary management orbital extramedullary plasmacytoma.Methods:...
Physical examination can identify palpable splenomegaly easily, but evaluating lesser degrees of is problematic. Hand-carried ultrasound allows rapid bedside assessment patients. We conducted this study to determine whether hand-carried reliably assess spleen size.Patients with varying were studied. Two sonographers blindly measured size in each patient using either a or conventional device random order. Sonographers completed data sheet indicating the adequacy image, clinical measurements...
Abstract Caloric restriction (CR) is known to extend lifespan across different species and holds great promise for preventing human age-onset pathologies. However, two major challenges exist. First, despite extensive research, the mechanisms of extension in response CR remain elusive. Second, genetic differences causing variations factors contributing variability on are largely unknown. Here, we took advantage natural variation 46 diploid wild yeast isolates Saccharomyces under conditions...
Caloric restriction (CR) is known to extend lifespan across different species and holds great promise for preventing human age-onset pathologies. However, two major challenges exist. First, despite extensive research, the mechanisms of extension in response CR remain elusive. Second, genetic differences causing variations factors contributing variability on are largely unknown. Here, we took advantage natural variation 46 diploid wild yeast isolates Saccharomyces under conditions uncover...