The "General Oral Health Assessment Index" (GOHAI) was widely used in clinical or epidemiological studies worldwide, as it available for use different languages. Therefore, the aim of this study to evaluate psychometric characteristics GOHAI a representative sample patients with schizophrenia. A total 90 schizophrenic (in-patients and out-patients) were recruited from participants "buccodor study" (NCT02167724) between March September 2015. They selected using random stratified sampling...

Overexpression of ferritin heavy chain ( FTH1 ) often associates with good prognosis in breast cancer (BCa), particularly the triple‐negative subtype (triple‐negative cancer). However, mechanism by which exerts its possible tumor suppressor effects BCa is not known. Here, we examined bearing silencing or overexpression on several aspects cell growth vitro . promoted and mammosphere formation, increased c‐MYC expression, reduced sensitivity to chemotherapy. In contrast, inhibited growth,...

Graphical Abstract Antibacterial activity of small molecules which eradicate methicillin-resistant Staphylococcus aureus (MRSA) persisters.

Mounting evidence points to a link between growth differentiation factor-15 (GDF15) expression and the onset progression of diabetes mellitus. However, exact role GDF15 in pancreatic β-cell function is unclear. To examine function, bioinformatics analysis functional experiments involving silencing overexpression were performed INS-1 cells human islets. Public microarray RNA-seq data showed that islets obtained from diabetic donors express high levels compared normal donors. Moreover,...

Multidrug-resistant bacterial infections present a serious challenge to global health. In addition the spread of antibiotic resistance, some bacteria can form persister cells which are tolerant most antibiotics and lead treatment failure or relapse. work, we report discovery new class small molecules with potent antimicrobial activity against Gram-positive moderate Gram-negative drug-resistant pathogens. The compound SIMR 2404 had minimal inhibitory concentration (MIC) 2 μg/mL...

Abstract Background Despite the pivotal role of dental implants in restorative dentistry, persistent microbial adhesion and biofilm formation on implant surfaces pose significant challenges, often leading to peri-implant diseases failure. Antimicrobial coatings, particularly those employing titanium dioxide (TiO 2 ) graphene, show promise addressing these issues by harnessing their potent antimicrobial properties upon UV activation. Here, we present a facile method for depositing graphene...

The main protease of SARS-CoV-2 virus, Mpro, is an essential element for viral replication, and inhibitors targeting Mpro are currently being investigated in many drug development programs as a possible treatment COVID-19. An vitro pilot screen highly focused collection compounds was initiated to identify new lead scaffolds Mpro. These efforts identified number hits. most effective these compound SIMR-2418 having inhibitory IC50 value 20.7 μM. Molecular modeling studies were performed...

WaaL is an inner membrane glycosyltransferase that catalyzes the transfer of O-antigen polysaccharide from its lipid-linked intermediate to a terminal sugar lipid A-core oligosaccharide, conserved step in lipopolysaccharide biosynthesis. Ligation occurs at periplasmic side bacterial cell membrane, suggesting catalytic region faces periplasm. Establishing topology protein family will enable understanding mechanism and exploit it as potential antimicrobial target. Applying oxidative labeling...

Nitrogen and oxygen medium rings, in particular nine-membered epitomize a unique area of chemical space that occurs many natural products biologically appealing compounds. The scarcity 8- to 12-membered rings among clinically approved drugs is indicative the difficulties associated with their synthesis, principally owing unfavorable entropy transannular strain. We report here scandium triflate-catalyzed reaction allows for modular access diverse collection ring heterocycles one-pot cascade...

Candida albicans is the leading cause of life-threatening bloodstream candidiasis, especially among immunocompromised patients. The reversible morphological transition from yeast to hyphal filaments in response host environmental cues facilitates C. tissue invasion, immune evasion, and dissemination. Hence, it widely considered that filamentation represents one major virulence properties albicans. We have previously characterized Ppg1, a PP2A-type protein phosphatase controls filament...

Summary Lipid A anchors the lipopolysaccharide (LPS) to outer membrane and is usually composed of a hexa‐acylated diglucosamine backbone. Burkholderia cenocepacia , an opportunistic pathogen, produces mixture tetra‐ penta‐acylated lipid A. “Late” acyltransferases add secondary acyl chains after incorporation four primary Here, we report that B. has only one late acyltransferase, LpxL (BCAL0508), which adds myristoyl chain 2′ position resulting in We also identified PagL (BCAL0788), acts as...

Abstract Background The aim of this study was to test the General Oral Health Assessment Index Questionnaire (GOHAI) items for differential item functioning (DIF) according demographic characteristics (gender, age) and mental health status (schizophrenic disorders versus general population) using Rasch analysis. Methods This is a cross-sectional aggregated baseline data from validation GOHAI in French population (GP) similar persons with schizophrenia (PWS). DIF tested Partial Credit Model....

Abstract We present a divergent strategy that permits access to diversely functionalized benzoxazepinium scaffolds fused various heterocycles. The described features one-pot combination of the Groebke–Blackburn–Bienaymé reaction and an aza-Michael addition. Methyl (E)-4-(2-formylphenoxy)but-2-enoate its derivatives are utilized as central elements in this cascade. These building blocks reacted with variety amino-azines tert-butyl isocyanide under ytterbium triflate [Yb(OTf)3] catalysis....

Abstract Background The aim of this work was to present the creation appropriate tools evaluate coping strategies in Oral-Health-related Quality Life (OHrQOL) implemented by persons with schizophrenia (PWS), Schizophrenia Coping Oral Health Profile (SCOOHP), and results a feasibility study. Methods A qualitative investigation conducted between June 2016 May 2017. first step included 26 semi-structured individual interviews, 20 PWS 6 health professionals (HPs), 2 focus groups (PWS HPs)...

Candida albicans is a common pathogenic fungus that presents challenge to healthcare facilities. It can switch between yeast cell form diffuses through the bloodstream colonize internal organs and filamentous penetrates host mucosa. Understanding pathogen's strategies for environmental adaptation and, ultimately, survival, crucial. As complementary study, herein, multi-omics analysis was performed using high-resolution timsTOF MS compare proteomes metabolomes of Wild Type (WT) (strain DK318)...

The United Arab Emirates (UAE) serves as an effective epidemiological site for assessing

Coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) initially emerged in December and has subsequently expanded globally, leading to the ongoing pandemic. The extensive spread of various SARS-CoV-2 variants possesses a serious public health threat. An literature search along with deep analysis was performed describe evaluate characteristics concern relation effectiveness current vaccines therapeutics. obtained results showed that several...

Correction to:Sequencing Groebke–Blackburn–Bienaymé and Aza-Michael Addition Reactions: A Modular Strategy for Accessing a Diverse Collection of Constrained Benzoxazepine Imidazopyrazine SystemsSynthesis 2021; 53(11): 1911-1922DOI: 10.1055/s-0040-1706006

Abstract Multidrug-resistant bacterial infections present a serious challenge to global health. In addition the spread of antibiotic resistance, some bacteria can form persister cells which are tolerant most antibiotics and lead treatment failure or relapse. work, we report discovery new class small molecules with potent antimicrobial activity against Gram-positive moderate Gram negative drug resistant pathogens. The compound SIMR 2404 had minimal inhibitory concentration (MIC) 2 µg/ml...