A5081894249- Cardiovascular and exercise physiology
- Cardiac Health and Mental Health
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Hemodynamic Monitoring and Therapy
- Stroke Rehabilitation and Recovery
- Cardiovascular Effects of Exercise
- Cardiac Imaging and Diagnostics
- Cardiac pacing and defibrillation studies
- Heart Rate Variability and Autonomic Control
- Health Systems, Economic Evaluations, Quality of Life
- Pulmonary Hypertension Research and Treatments
- Non-Invasive Vital Sign Monitoring
- Muscle activation and electromyography studies
- Nutrition and Health in Aging
- Acute Myocardial Infarction Research
- Telemedicine and Telehealth Implementation
- Atrial Fibrillation Management and Outcomes
- Blood Pressure and Hypertension Studies
- COVID-19 and healthcare impacts
- Dialysis and Renal Disease Management
- Dental Radiography and Imaging
- Radiology practices and education
- Sinusitis and nasal conditions
- Cardiac Arrest and Resuscitation
Máxima Medisch Centrum
2015-2024
Radboud University Nijmegen
2015-2024
X Flow (Netherlands)
2021-2022
Netherlands Heart Institute
2016-2019
In patients with chronic heart failure (HF), the MONITOR-HF trial demonstrated efficacy of pulmonary artery (PA)-guided HF therapy over standard care in improving quality life and reducing hospitalizations mean PA pressure. This study aimed to evaluate consistency these benefits relation clinically relevant subgroups.
Cardiac rehabilitation has beneficial effects on morbidity and mortality in patients with coronary artery disease, but is vastly underutilised short-term improvements are often not sustained. Telerehabilitation the potential to overcome these barriers, its superiority been convincingly demonstrated yet. This may be due insufficient focus behavioural change development of patients' self-management skills. Moreover, potentially communication methods, such as internet video consultation, rarely...
Objective. Near-infrared spectroscopy (NIRS) measurements of tissue oxygen saturation (StO2) are useful for the assessment skeletal muscle perfusion and function during exercise, however, they influenced by overlying skin adipose tissue. This study explored extent nature influence thickness (ATT) on StO2. Approach. NIR spatially resolved (SRS) derived oxygenation was measured vastus lateralis in 56 patients with chronic heart failure (CHF) 20 healthy control (HC) subjects rest moderate...
Abstract Background Despite proven clinical benefits, only a minority of patients complete outpatient cardiac rehabilitation (CR) after acute myocardial infarction (AMI). The main purpose this study was to evaluate what extent and at which time drop out CR, assess patient-related characteristics can predict dropout. Methods In retrospective cohort study, we selected who had been hospitalised with an AMI in our centre 2015 or 2016. Patients were pseudonymously based on reimbursement codes the...
Assessing haemodynamic congestion based on filling pressures instead of clinical can be a way to further improve quality life (QoL) and outcome by intervening before symptoms or weight gain occur in heart failure (HF) patients. The efficacy remote monitoring pulmonary artery (PA) (CardioMEMS; Abbott Inc., Atlanta, GA, USA) has been demonstrated the USA. Currently, PA sensor is not reimbursed European Union as its benefit when applied addition standard HF care unknown Western countries,...
Summary The potential purpose of near‐infrared spectroscopy ( NIRS ) as a clinical application in patients with chronic heart failure CHF is the identification limitations O 2 delivery or utilization during exercise. objective this study was to evaluate absolute and relative test–retest reliability skeletal muscle oxygenation measurements . Thirty systolic (left ventricular ejection fraction 31 ± 8%) performed 6‐min constant‐load cycling tests at 80% anaerobic threshold (AT) tissue...
High-intensity interval training (HIT) improves exercise capacity in patients with chronic heart failure (CHF). Moreover, HIT was associated improved resting cardiac function. However, the extent to which these improvements actually contribute training-induced changes remains be elucidated. Therefore, we evaluated effects of on exercising central haemodynamics and skeletal muscle oxygenation. Twenty-six CHF were randomised a 12-week 4 × minute program at 85–95% peak VO2 or usual care....
Abstract Aims Heart failure (HF), a global pandemic affecting millions of individuals, calls for adequate predictive guidance improved therapy. Congestion, key factor in HF‐related hospitalizations, further underscores the need timely interventions. Proactive monitoring intracardiac pressures, guided by pulmonary artery (PA) pressure, offers opportunities efficient early‐stage intervention, since haemodynamic congestion precedes clinical symptoms. Methods The BioMEMS study, substudy...
Abstract Background Guideline adherence with respect to exercise-based cardiac rehabilitation (CR) is hampered by a large variety of complex guidelines and position statements, the fact that these documents are not specifically designed for healthcare professionals prescribing CR programs. This study aimed develop clinical algorithms can be used in practice prescription evaluation patients coronary artery disease (CAD) chronic heart failure (CHF). Methods The were developed using systematic...
The extent and speed of transient skeletal muscle deoxygenation during exercise onset in patients with chronic heart failure (CHF) are related to impairments local O2 delivery utilization. This study examined the physiological background submaximal performance 19 moderately impaired CHF (Weber class A, B, C) compared matched healthy control (HC) subjects by measuring oxygenation (SmO2) changes cycling exercise. All performed two subsequent moderate-intensity 6-min tests (bouts 1 2)...
Skeletal muscle function in patients with heart failure and reduced ejection fraction (HFrEF) greatly determines exercise capacity. However, reports on skeletal fiber dimensions, capillarization, their physiological importance are inconsistent. Twenty-five moderately impaired HFrEF 25 healthy control (HC) subjects underwent biopsy sampling. Type I type II characteristics were determined by immunohistochemistry. In HFrEF, enzymatic oxidative capacity was assessed, pulmonary oxygen uptake...
Oxygen uptake (V̇o2) kinetics are prolonged in patients with chronic heart failure (CHF). This may be caused by impaired oxygen delivery or skeletal muscle derangements. We investigated whether cardiac output (Q̇) limit relative to the metabolic demands at submaximal exercise CHF evaluating relation between Q̇ and deoxygenation. Forty-three patients, NYHA II-III, performed a constant-load test 80% of ventilatory aerobic threshold (VAT) assess V̇o2 (τV̇o2). (τQ̇) were assessed radial artery...
Stress echocardiography (SE) has recently regained momentum as an important diagnostic tool for the assessment of both ischemic and non-ischemic heart disease. Performing SE during physical exercise is challenging due to a suboptimal patient position vigorous movements patient's chest. This hampers stable ultrasound reduces performance SE. A probe would facilitate producing high quality images continuous measurements. With Probefix (Usono, Eindhoven, The Netherlands), newly developed fixate...
The oxygen uptake efficiency slope (OUES) is an exercise parameter with strong prognostic value in the heart failure population. Yet, optimal determination method of OUES remains unclear. purpose present study was to investigate influence ventilatory anaerobic threshold (VAT) and occurrence a plateau (VO2) on from submaximal data patients chronic (CHF).Ninety-eight CHF (New York Heart Association class II-III) were included. All performed symptom-limited test gas exchange analysis cycle...
Patients with chronic heart failure (CHF) suffer from exercise intolerance due to impaired central hemodynamics and subsequent alterations in peripheral skeletal muscle function structure. The relative contribution of versus factors the reduced capacity is still subject debate. main purpose was investigate heterogeneity nature by evaluating individual cardiac output (Q) patterns. secondary evaluate whether patient disease characteristics were associated a hemodynamic limitation. Sixty-four...
The cardiovascular benefits of physical exercise are well-known. However, vigorous has also been associated with adverse cardiac effects. To improve our understanding adaptation to versus maladaptation and pathology, the limits should be firmly established using state-of-the-art diagnostic modalities. We therefore initiated Evaluation Lifetime participation in Intensive Top-level sports Exercise (ELITE) cohort investigate longitudinal (beneficial pathological) effects intensive elite exercise.