A5018571839- Perovskite Materials and Applications
- Conducting polymers and applications
- Vehicle Routing Optimization Methods
- Cancer, Lipids, and Metabolism
- SARS-CoV-2 and COVID-19 Research
- Cholesterol and Lipid Metabolism
- Fatty Acid Research and Health
- Facility Location and Emergency Management
- Prostate Cancer Treatment and Research
- Vaccine Coverage and Hesitancy
- Quantum Dots Synthesis And Properties
- Prostate Cancer Diagnosis and Treatment
- Optimization and Mathematical Programming
- COVID-19 Clinical Research Studies
- Advanced Chemical Sensor Technologies
- Blood properties and coagulation
- Chalcogenide Semiconductor Thin Films
- Inflammatory Biomarkers in Disease Prognosis
- Diet, Metabolism, and Disease
- Drug Transport and Resistance Mechanisms
- Advanced Battery Materials and Technologies
- Supply Chain and Inventory Management
- Tree-ring climate responses
- Peroxisome Proliferator-Activated Receptors
- Conservation Techniques and Studies
Guang’anmen Hospital
2021-2024
Qiqihar University
2023-2024
Sun Yat-sen University
2023
Baidu (China)
2022
Sichuan University
2013-2022
Jiangnan University
2021-2022
University of Shanghai for Science and Technology
2020-2021
Zhongyuan University of Technology
2021
Xidian University
2017-2020
Chongqing University
2020
A vaccine against coronavirus disease 2019 (COVID-19) is urgently needed.To evaluate the safety and immunogenicity of an investigational inactivated whole-virus COVID-19 in China.In phase 1 trial, 96 participants were assigned to 3 dose groups (2.5, 5, 10 μg/dose) aluminum hydroxide (alum) adjuvant-only group (n = 24 each group), received intramuscular injections at days 0, 28, 56. In 2 224 adults randomized 5 μg/dose schedule (injections on 0 14 [n 84] vs alum only 28], 21 28]).Interim...
Abstract Lead halide perovskites have attracted increasing attention in photovoltaic devices, light‐emitting diodes, photodetectors, and other fields due to their excellent properties. Besides optoelectronic growing numbers of studies focused on the perovskite‐based electrical devices past few years, such as transistors resistive random access memories (RRAMs). Here, this article summarizes recent progress researchers made RRAM devices. Primarily, working mechanism key parameters are...
The charge transport layer is crucial to the performance and stability of perovskite solar cells (PSCs). Compared with other conventional metal oxide electron materials, SnO 2 has a deeper conduction band higher mobility, can efficiently serve as an facilitate extraction transfer. Herein, optimized low‐temperature solution‐processed achieved by doping polyethylenimine polyelectrolyte into for first time in PSCs. It found that all aspects doped film improved over pristine film. better energy...
Streptomyces mobaraenesis transglutaminase has been widely used in food processing. We here significantly improved the catalytic properties of S2P-S23V-Y24N-S199A-K294L (TGm1), a highly stabilized variant transglutaminase. First, virtual proline scan was performed based on folding free energy changes to obtain TGm1 variants with enhanced thermostability. Second, residues within 15 Å Cys64 enzyme-substrate complex were subjected saturation mutagenesis generate reduced binding and increased...
Abstract Mountain treelines are thought to be sensitive climate change. However, how impacts mountain is not yet fully understood as may also affected by other human activities. Here, we focus on “closed‐loop” (CLMT) that completely encircle a and less likely have been influenced land‐use We detect total length of ~916,425 km CLMT across 243 ranges globally reveal bimodal latitudinal distribution treeline elevations with higher occurring at greater distances from the coast. Spatially, find...
BackgroundWe aimed to assess the safety and immunogenicity of an inactivated vaccine against COVID-19 in Chinese adults aged ≥18 years.MethodsThis is ongoing randomized, double-blind, placebo-controlled, phase 1/2 clinical trial among healthy years Henan Province, China. Participants (n = 336 18–59 age group n ≥60 group) were enrolled between April 12 May 17 2020, equally randomized receive or placebo (aluminum hydroxide adjuvant) a three-dose schedule 2·5, 5, 10 µg on days 0, 28, 56....
Abstract As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to threaten public health worldwide, development of effective interventions is urgently needed. Neutralizing antibodies (nAbs) have great potential for prevention and treatment SARS-CoV-2 infection. In this study, ten nAbs were isolated from two phage-display immune libraries constructed pooled PBMCs eight COVID-19 convalescent patients. Eight them, consisting heavy chains encoded by immunoglobulin...
Extracellular microRNA (miRNA) (exosomal miRNA) embedded in exosomes plays a vital role the progression of calcium oxalate disease. This study aimed to identify dysregulated miRNA expression profiles and their biological functions urinary patients with oxalate. Ultrahigh-speed centrifugation Illumina high-throughput sequencing were used isolate detect levels exocrine miRNAs urine samples from 10 stones matched normal persons, construct differential profiles. Bioinformatics analysis...
Safe and effective vaccines against SARS-CoV-2 for children are urgently needed. Here we aimed to assess the safety immunogenicity of an inactivated COVID-19 vaccine candidate, WIBP-CorV, in participants aged 3-17 years. A randomized, double-blind, placebo-controlled, phase 1/2 clinical trial was conducted Henan Province, China, healthy 240 1 576 2 were randomly assigned or control with age de-escalation three cohorts (3-5, 6-12 13-17 years) dose-escalation groups (2.5, 5.0 10.0μg/dose),...
Planar perovskite solar cells (PSCs) with and [6,6]-phenyl-C61-butyric acid methyl ester (PCBM) heterojunction have attracted much interest because they can be fabricated by a low-temperature process exhibit high power conversion efficiency (PCE). Various compositional engineering interface approaches been applied to produce high-performance PSC devices. In this study, we found that high-quality lead halide crystal precursor has significant effect on the film quality it could enhance light...
Abstract Background Streptomyces mobaraenesis transglutaminase (smTG) is widely used to generate protein crosslinking or attachment of small molecules. However, the low thermostability a main obstacle for smTG application. In addition, it still hard achieve secretory expression active in E. coli , which benefits enzyme evolution. this study, combined strategy was conducted improve and . Results First, thermostable S. variant S2P-S23V-Y24N-S199A-K294L (TGm1) intracellularly expressed...
To solve the odor emission problem of lacquer veneer particleboards, as well to identify key compounds and their sources, alkyd resin enamel-coated particleboards were studied via gas chromatography-mass spectroscopy-olfactometry. A single-factor experiment was established under various environmental conditions. The odor-causing identified, effects factors on volatile organic (VOCs) emissions investigated. results showed that main substances released from particleboard aromatic compounds,...
Abstract Phospholipid (PL) from both dietary sources and biliary secretions may be important in the regulation of intestinal apolipoprotein (apo) synthesis. We previously demonstrated up‐regulation apo A‐I secretion by phosphatidylcholine (PC) a newborn piglet epithelial cell line. hypothesized that PC increases small synthesis vivo piglet. Two‐day‐old female swine were fed gavage for 48 h. Diets consisted formula containing 51% calories as triacylglycerol providing 180 kcal/kg/24 The...
Long-chain polyunsaturated fatty acids (LC-PUFA) are important in the development of immature nervous system, and adding these to infant formula has been proposed. To determine effect n-3 LC-PUFA on apolipoprotein secretion lipid synthesis newborn swine enterocytes, differentiated IPEC-1 cells were incubated for 24 h with docosahexaenoic acid (DHA; 22:6) or eicosapentaenoic (EPA; 20:5) complexed albumin at a concentration 0.8 mM alone (control) added apical medium. Oleic (OA; 18:1) was used...
Accumulating evidence indicates that a graft‐vs.‐myeloma effect (GVM) and its associated clinical remission of the disease can be induced by donor lymphocyte infusion in myeloma patients who have relapsed after allogeneic bone marrow transplantation. Although it is believed GVM allospecific T cells, T‐cell subsets mechanisms involved killing cells not been studied. In this study, we generated cytotoxic (CTL) lines against three different cell lines, ARK, ARP‐1 U266, from unmatched healthy...
Abstract It is well known that the release of volatile organic compounds (VOCs) and odors from wood-based panels harmful to human health. The VOCs emitted decorative have been investigated generally, but information limited regarding key odor people find most irritating. In this experiment, particleboard coated with nitrocellulose lacquer was analyzed by gas chromatography coupled mass spectrometry olfactometry. Twenty were identified, which arose between 5 25 minutes. Most odorants...
In recent years, natural disasters occur frequently, and secondary induced by major will also cause huge losses. The diversity of makes humanitarian emergency logistics (HEL) more challenging but often overlooked researchers. order to solve the comprehensive HEL problem disasters, a three-stage mixed integer linear optimization (TS-MILO) model is proposed. Among them, uncertainty demand for relief supplies extremely difficult deal with. resist interference uncertainty, based on robust...
The IPEC-1 newborn swine intestinal epithelial cell line was used to determine the effects of uptake various fatty acids on secretion apolipoprotein (apo) B and apo A-I, as well triglyceride phospholipid. Long-chain saturated were taken up stimulated synthesis, palmitic (16:0) stearic (18:0) also phospholipid synthesis. However, these did not enhance triglyceride, phospholipid, or A-I secretion. Oleic acid (18:1) most effective all tested in stimulating synthesis B. Linoleic (18:2) linolenic...