A5100705911- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Vectors
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Vector-Borne Animal Diseases
- Respiratory viral infections research
- vaccines and immunoinformatics approaches
- COVID-19 Impact on Reproduction
- Pregnancy-related medical research
- Mosquito-borne diseases and control
- Fire effects on ecosystems
- Viral gastroenteritis research and epidemiology
- Biosensors and Analytical Detection
- Maternal and Perinatal Health Interventions
- SARS-CoV-2 detection and testing
- Vaccine Coverage and Hesitancy
- Hidradenitis Suppurativa and Treatments
- Antifungal resistance and susceptibility
- Transgenic Plants and Applications
- Lymphatic System and Diseases
- Maternal and fetal healthcare
- Monoclonal and Polyclonal Antibodies Research
- Cytomegalovirus and herpesvirus research
- Cancer survivorship and care
- Breastfeeding Practices and Influences
Dalian Medical University
2024
Chongqing Medical University
2022-2024
Second Affiliated Hospital of Chongqing Medical University
2024
Wuhan Institute of Virology
2021-2023
Chinese Academy of Sciences
2021-2023
Wuhan Institute of Bioengineering
2021-2023
Jingning County People's Hospital
2022-2023
Women's and Children's Hospital
2021-2023
Huazhong Agricultural University
2017-2021
Center of Hubei Cooperative Innovation for Emissions Trading System
2017-2021
SARS-CoV-2 continues to accumulate mutations evade immunity, leading breakthrough infections after vaccination. How researchers can anticipate the evolutionary trajectory of virus in advance design next-generation vaccines requires investigation. Here, we performed a comprehensive study 11,650,487 sequences, which revealed that spike (S) protein evolved not randomly but into directional paths either high infectivity plus low immune resistance or resistance. The viral and variants are...
Abstract As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to threaten public health worldwide, development of effective interventions is urgently needed. Neutralizing antibodies (nAbs) have great potential for prevention and treatment SARS-CoV-2 infection. In this study, ten nAbs were isolated from two phage-display immune libraries constructed pooled PBMCs eight COVID-19 convalescent patients. Eight them, consisting heavy chains encoded by immunoglobulin...
Transmissible gastroenteritis virus (TGEV), an enteropathogenic coronavirus (CoV) of porcine, causes lethal watery diarrhea and severe dehydration in piglets leads to economic losses the swine industry. Unlike most CoVs that antagonize type I interferon (IFN) production, previous studies showed TGEV infection induces IFN-I production both vivo vitro. However, underlying mechanism(s) remain largely unknown. In this study, we found significantly facilitated IFN-β as well activation...
Crimean-Congo hemorrhagic fever (CCHF) is a severe tick-borne viral disease of global concerns due to the increasing incidence and lack effective treatments. The causative agent, CCHF virus (CCHFV), has been characterized for years; however, its tropism in cell lines different host tissue origins remains unclear. This study susceptibility 16 human 6 animal CCHFV. Increased load nucleoprotein expression, productive CCHFV replication were detected vascular (HUVEC), renal (SW-13 HEK-293),...
Invasive fungal infections (IFIs) pose a significant threat to immunocompromised individuals, leading considerable morbidity and mortality. Prompt accurate diagnosis is essential for effective treatment. Here we develop rapid molecular diagnostic method that involves three steps: enrichment using affinity-magnetic separation (AMS), genomic DNA extraction with silicon hydroxyl magnetic beads, detection through one-pot system. This method, optimized detect 30 CFU/mL of C. albicans in blood...
To investigate efficacy of early prevention complex decongestive therapy and rehabilitation exercise for postoperative lower limb extremity lymphedema patients with gynecologic cancer.109 female were randomly divided into two groups, the control group who only received routine treatment CDT both exercise. For exercise, additional strategy including professional education full range hip joint. The incidence was recorded. A simple scale patients' designed. diameter low limbs (both thighs...
To evaluate the outcomes and risk factors for trial of labor after cesarean delivery (TOLAC) failure in patients China.Consecutive who had a previous (CD) attempted TOLAC were included from 2014 to 2020. Patients successfully delivered classified into success group. but repeat CD due medical issues Multiple logistic regression analyses performed examine failure.In total, 720 women identified included. The rate was 84.2%(606/720). Seven diagnosed with uterine rupture, none whom underwent...
Severe fever with thrombocytopenia syndrome (SFTS), caused by SFTS virus (SFTSV) infection, was first reported in 2010 China an initial fatality of up to 30%. The laboratory confirmation SFTSV infection terms detection viral RNA or antibody levels is critical for diagnosis and therapy. In this study, a new luciferase immunoprecipitation system (LIPS) assay based on pREN2 plasmid expressing NP gene tagged Renilla (Rluc), established used investigate the responses SFTSV. Totally 464 serum...
Severe fever with thrombocytopenia syndrome virus (SFTSV), Heartland (HRTV) and Guertu (GTV) belong to the severe syndrome/Heartland group of genus Bandavirus in family Phenuiviridae order Bunyavirales. HRTV, identified from ticks Asia America, respectively, are important pathogens causing febrile diseases humans. virus, closely related these two viruses, is a potential pathogen, but no confirmed infection has been identified. So far, human-derived neutralizing monoclonal antibodies (mAbs)...
Human herpes simplex virus (HSV), a double-stranded DNA belonging to the Herpesviridae family and alpha herpesvirus subfamily, is one of most epidemic pathogens in population. Cell-to-cell spread special intercellular transmission mechanism HSV that indicates virulence this virus. Through numerous studies on mutant strains, many viral host proteins involved process have been identified; however, mechanisms remain poorly understood. Here, we evaluated effect membrane protein genes US7 UL56...
Abstract Background: Effective therapeutics and vaccines for coronavirus disease 2019 (COVID-19) are currently lacking because of the mutation immune escape severe acute respiratory syndrome 2 (SARS-CoV-2). Based on propagation characteristics SARS-CoV-2, rapid accurate detection complete virions from clinical samples environment is critical assessing infection risk containing further COVID-19 outbreaks. However, applicable methods cannot achieve large-scale application factors such as high...
Abstract SARS-CoV-2 continued to spread globally along with different variants. Here, we systemically analyzed viral infectivity and immune-resistance of variants explore the underlying rationale mutagenesis. We found that Beta variant harbors both high strong immune resistance, while Delta is most infectious only a mild immune-escape ability. Remarkably, Omicron even more immune-resistant than variant, but its increases in Vero E6 cells implying probable preference for endocytic pathway. A...
<title>Abstract</title> Pyoderma gangrenosum(PG) is an uncommon form of ulcerative neutrophilic dermatosisan(ND) presented as painful ulcerated skin at sites injury or surgery. A 19-year-old primigravida was found signs wound defects liking surgical site infection after caesarean section. Despite antibiotic treatment and consecutive debridement procedures were all performed, progressive deterioration the occurred. PG diagnosed by clinically necrosis negative cultures. After several weeks,...
The coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome 2 (SARS-CoV-2), has posed a potential threat to infant health. World Health Organization recommended that the benefits of breastfeeding far outweigh risk transmission, but there no denying current evidence insufficient. Moreover, although COVID-19 mRNA vaccine played an effective role in protection against infection, individuals have increasing concerns about safety after vaccination, and some women...
Effective therapeutics and vaccines for coronavirus disease 2019 (COVID-19) are currently lacking because of the mutation immune escape severe acute respiratory syndrome 2 (SARS-CoV-2). Based on propagation characteristics SARS-CoV-2, rapid accurate detection complete virions from clinical samples environment is critical assessing infection risk containing further COVID-19 outbreaks. However, applicable methods cannot achieve large-scale application due to factors such as high viral load,...