A5077557448- Childhood Cancer Survivors' Quality of Life
- Glioma Diagnosis and Treatment
- Family Support in Illness
- Palliative Care and End-of-Life Issues
- Neuroblastoma Research and Treatments
- Adolescent and Pediatric Healthcare
- Family and Patient Care in Intensive Care Units
- Pediatric Pain Management Techniques
- Ethics and Legal Issues in Pediatric Healthcare
- Mental Health and Patient Involvement
- Infant Development and Preterm Care
- Cancer survivorship and care
- Cerebral Palsy and Movement Disorders
- Cancer Research and Treatments
- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Patient-Provider Communication in Healthcare
- Diet and metabolism studies
- Infant Health and Development
- Health Literacy and Information Accessibility
- Peptidase Inhibition and Analysis
- Brain Metastases and Treatment
- COVID-19 and Mental Health
- Ubiquitin and proteasome pathways
- Radiomics and Machine Learning in Medical Imaging
Medical University of Vienna
2020-2025
Comprehensive Cancer Center Vienna
2022-2025
Vienna General Hospital
2020-2024
St Anna Children's Hospital
2023
Community College of Rhode Island
2023
Universitätsklinik für Kinder und Jugendpsychiatrie
2020-2022
University of Vienna
2020
Zentrum für Kinderheilkunde
2018
FH Campus Wien
2018
Importance Medulloblastoma recurrence in patients who have previously received irradiation has a dismal prognosis and lacks standard salvage regimen. Objective To evaluate the response rate of pediatric with medulloblastoma using an antiangiogenic metronomic combinatorial approach (Medulloblastoma European Multitarget Metronomic Anti-Angiogenic Trial [MEMMAT]). Design, Setting, Participants This phase 2, investigator-initiated, multicenter nonrandomized controlled trial assessed 40 relapsed...
Abstract Background Patient and public involvement engagement (PPIE) in healthcare research is crucial for effectively addressing patients' needs setting appropriate priorities. However, there a lack of awareness adequate methods practicing PPIE, especially vulnerable groups like childhood cancer survivors. Aims This project aimed to develop evaluate actively involve pediatric oncological patients, survivors, their caregivers developing relevant questions practical study designs. Methods...
Abstract Background Public and Patient Involvement Engagement (PPIE) in research is still a poorly understood infrequently practiced concept, although the literature stresses clear benefits for quality of care as well patient satisfaction empowerment. Aim The presently described project aimed at using different PPIE methods to evaluate current state knowledge about attitude toward among stakeholders pediatric oncology Europe. Based on findings tailored training tool directed will be...
Abstract Objective In paediatric oncology, little is known about trajectories of illness perceptions and their longitudinal associations with health‐related quality life (HRQoL). Therefore, the aim this study was to investigate changes in children parents over a one‐year‐period predictive value child's parent's during acute treatment for HRQoL 1 year later. Methods N = 65 child‐parent‐dyads participated (retention rate: 80.2%). Children were 4–18 years age underwent cancer at baseline....
Zusammenfassung Gesundheitskompetenz spielt eine entscheidende Rolle für pädiatrische Patient:innen und bedeutet, Gesundheit bzw. Krankheit zu verstehen, erhalten verbessern. Sie ist assoziiert mit effektivem Coping Lebensqualität. Eine adaptierte Version der Gesundheitskompetenzskala wurde genutzt, um Gesundheitsüberzeugungen Copingstrategien von 197 hochgesunden Kindern Jugendlichen deren Eltern erfassen. Die Ergebnisse zeigen hohe Einschätzungen seitens soziale Einschränkungen (90,1 %) im...
Abstract PDGFRA is commonly altered in pediatric and young adult high-grade gliomas (pHGGs) including histone 3 lysine 27-mutated diffuse midline (H3K27M DMG), a fatal disease with no current options for cure. We performed comprehensive genomic transcriptomic analyses of n=259 glioma cases which revealed alterations ~15% patients. H3K27M DMGs had significantly higher expression compared to H3 wild-type tumors regardless alteration. Tumors gene amplification demonstrated elevated both pHGGs...
Abstract Background Psychosocial guidelines and standards systematically describe stressors resources in particularly challenging situations hence serve as a basis for interventions to achieve defined psychosocial goals. Despite fundamental principles methods, the quality of provided care varies considerably depending on setting, provision, profession. The purpose present protocol is illustrate development evaluation standardized psychological intervention “My Logbook”, practical guide...
Abstract Many adolescents and young adult (AYAs) childhood cancer survivors face disease- or therapy-related late-effects, which limit their participation in various areas of daily life. AYAs are often left alone our health care system, many worry about ability to cope with long-term sequelae, some even lost follow-up. Therefore, the present study, a targeted aftercare program was developed evaluated goal facilitating three important “life skills”: (1) self-perception, (2) social interaction...
To provide an effective alternative to sedation during MRI examinations in pediatric cancer and NF1 patients, the aims of present study were (1) exploratively evaluate a behavioral training program, (2) investigate potential moderators, as well (3) assess patients' well-being over course intervention. A total n = 87 patients neuro-oncology unit (mean age: 6.83 years) underwent two-step preparation including inside scanner, recorded using process-oriented screening. In addition retrospective...
Abstract H3K27M-mutated diffuse midline glioma (H3K27M DMG) are an almost universally fatal disease with a median survival of less than 6 months post progression and no effective therapy. PDGFRA-signaling has shown to promote sustain subset oligodendrocyte precursor-like tumor cells that responsible for propagating potential high proliferation rates. However, first attempts target PDGFRA in adult glioblastoma dasatinib/imatinib or pediatric refractory brain tumors sunitinib were not...
Abstract BACKGROUND Neuropsychological (i.e. cognitive, emotional and social) sequelae after pediatric brain tumors (PBT) can severely impair daily-life participation consequently quality of life. Long-term access to appropriate interventions is therefore essential. Previous studies on effectiveness have recommended multi-component tailored the specific neuropsychological impairments unique needs survivors. Hence, before conducting a new intervention study, we carried out participative...
Pediatric cancer is one of the most burdensome chronic diseases, necessitating a variety severe medical interventions. As result, disease and its treatment cause numerous acute long-term medical, psychological, socioeconomic strains for young patients their families. Therefore, psychosocial care using evidence-based interventions (EBIs) before, during, after treatments essential to ensure that receive adequate information minimize adverse emotional impacts such as insecurity, fear, shame....
Abstract Purpose Evidence-based interventions (EBIs) are essential to improve the well-being and neurocognitive outcomes of pediatric cancer patients; however, considerable barriers hamper implementation these tools. The present study assessed health care professionals’ (HCP) perceived facilitators a specific EBI for oncology in standardized manner define effective solutions practical recommendations. Methods An adapted version Consolidated Framework Implementation Research (CFIR)...
This study advances the idea of a visual tool for screening and tracking emotional states in therapeutic clinical setting thereby grounds development standardized means evaluating young patients' well-being sufficiently differentiated manner. Institutional Review Board StatementAll subjects this non-clinical sample participated anonymously no personal data was collected, hence, since participant is identifiable, ethical approval obtained study.Medical interventions, such as surgical...
Abstract PDGFRA has been shown to be commonly altered in high-grade gliomas (HGGs), including histone 3 lysine 27-mutated diffuse midline (H3K27M DMG), a disease with almost no long-term survivors. Here, we performed comprehensive genomic and transcriptomic analysis of 260 glioma cases, which revealed alterations (mutations and/or amplifications) 13% patients. H3K27M DMGs had significantly higher expression compared H3 wild-type tumors, gene amplification resulted even levels as well HGGs....
Abstract PDGFRA has been shown to be commonly altered in pediatric and young adult high-grade gliomas (pHGGs) including histone 3 lysine 27-mutated diffuse midline (H3K27M DMG), a disease with almost no long-term survivors. Here, we performed comprehensive genomic transcriptomic analyses of n=259 glioma cases which revealed alterations (mutations and/or amplifications) ~14.9% patients. We tested panel patient-derived HGG H3K27M DMG models against range inhibitors, found that avapritinib...
The present report describes the results of four delphi surveys conducted within quality improvement project "My Logbook" which aims to translate evidence-based standards for psychosocial care in pediatric oncology into a practical consensus-based tool.In consecutive total n=153 international, multi-disciplinary experts rated content, method, and design different booklets local expert group had conceptualized. After each survey, feedback was incorporated, changes were evaluated final...
Zusammenfassung Interdisziplinäre Kooperation aus psychosozialer Sicht Die professionelle Betreuung von jungen Krebspatienten beeinflusst ihr Wohlbefinden und ihre psychische Gesundheit während nach der onkologischen Erkrankung entscheidend. Diese gelingt am besten, wenn alle beteiligten Disziplinen als Team eng zusammenarbeiten.
Abstract Pediatric high-grade glioma (pHGG) is an incurable disease with a median survival of less than 6 months post-progression and no effective targeted therapy. PDGFRA commonly altered in pHGG, but targeting this has been unsuccessful, likely due to poor central nervous system (CNS) penetrance. Avapritinib novel CNS-penetrant PDGFRA/KIT inhibitor that FDA-approved for adults unresectable or metastatic exon 18-mutant gastrointestinal stromal tumor (GIST) being studied CNS tumors. We...
Abstract: Pediatric patients with chronic health conditions often suffer from social and academic exclusion. Since disease-centered assessments do not allow for differentiated biopsychosocial profiling, this study aims to evaluate the psychometric quality of “The School Participation Scales 24/7,” a novel ICF-CY-based assessment tool. Results show high fit indices most subscales, signifying structural equality between tool ICF-CY. Acceptable criterion validity is given established...
Abstract Language barriers have been reported to a detrimental effect on various outcomes in paediatric care, such as therapy adherence, and may even cause medical treatment errors. To address this issue, we developed set of 63 cards with which wide range specific messages can be conveyed nonverbally clinical context. The conceptualization the tool involved multiple phases. In Study 1, held workshop 11 children adolescents between 8 19 years that had received for oncological conditions gain...
Zusammenfassung: Unterstützung bei der schulischen Reintegration wird als standard of care in pädiatrischen Onkologie definiert. Ziel ist die Bereitstellung von Informationen und Koordination Kommunikation zwischen Patient_in/Familie, Schule Krankenhaus. Dies entscheidender Bedeutung für Schüler_innen mit Tumoren des Zentralnervensystems (ZNS), insbesondere Nachsorge, da sie eine Risikogruppe Spätfolgen darstellen. Um Kooperation zu verbessern, wurden mehrere praktische...