A5016199324- Renal cell carcinoma treatment
- Renal and related cancers
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Bladder and Urothelial Cancer Treatments
- Metabolomics and Mass Spectrometry Studies
- Cancer, Hypoxia, and Metabolism
- Prostate Cancer Diagnosis and Treatment
- Urinary Bladder and Prostate Research
- Urological Disorders and Treatments
- Diversity and Career in Medicine
- Pancreatic and Hepatic Oncology Research
- Renal and Vascular Pathologies
- Healthcare cost, quality, practices
- Hematopoietic Stem Cell Transplantation
- Cannabis and Cannabinoid Research
- Urinary and Genital Oncology Studies
- Sexual function and dysfunction studies
- Urticaria and Related Conditions
- Chronic Kidney Disease and Diabetes
- COVID-19 and healthcare impacts
- Pelvic floor disorders treatments
- Lipid metabolism and biosynthesis
- Biomarkers in Disease Mechanisms
- Autophagy in Disease and Therapy
University of Bari Aldo Moro
2019-2023
Virginia Cancer Institute
2022
VCU Massey Comprehensive Cancer Center
2022
Children's Hospital of Richmond at VCU
2022
Virginia Commonwealth University
2022
An altered metabolism is involved in the development of clear cell renal carcinoma (ccRCC). MUC1 overexpression has been found to be associated with advanced disease and poor prognosis. In this study, we evaluated metabolomic profile human ccRCC, according expression, integrated it transcriptomic data. Moreover, analyzed role sustaining ccRCC aggressiveness prognostic value its soluble form CA15-3. Integrated analysis showed that MUC1-expressing was characterized by metabolic reprogramming...
Mucin1 (MUC1), a glycoprotein associated with an aggressive cancer phenotype and chemoresistance, is aberrantly overexpressed in subset of clear cell renal carcinoma (ccRCC). Recent studies suggest that MUC1 plays role modulating metabolism, but its regulating immunoflogosis the tumor microenvironment remains poorly understood. In previous study, we showed pentraxin-3 (PTX3) can affect ccRCC by activating classical pathway complement system (C1q) releasing proangiogenic factors (C3a, C5a)....
Sexual function is often impaired in patients with chronic illnesses. Several gastrointestinal and liver disorders have been shown to suffer from sexual dysfunction, celiac disease a highly prevalent gastroenterological disorder.The aim of this study was investigate the incidence risk factors for dysfunction both male female patients.Two hundred eighty-four (170 females, 114 males) participated cross-sectional observational an anonymous manner. Female assessed through Function Index...
Clear cell renal carcinoma (ccRCC) is fundamentally a metabolic disease. Given the importance of lipids in many cellular processes, this study we delineated lipidomic profile human ccRCC and integrated it with transcriptomic data to connect variations cancer lipid metabolism gene expression changes. Untargeted analysis was performed on 20 paired normal tissues, using LC-MS GC-MS. Different classes were altered compared tissue. Among long chain fatty acids (LCFAs), significant accumulations...
Purpose: To compare outcomes of robot-assisted partial nephrectomy (RAPN) and percutaneous tumor ablation (PTA) for completely endophytic renal masses. Methods: Data patients who underwent RAPN or PTA treatment (three points "E" domain R.E.N.A.L. score) were collected from seven high-volume U.S. European centers. included cryoablation, radiofrequency, microwave ablation. Baseline characteristics, clinical, surgical, postoperative compared. Recurrence-free survival (RFS) was calculated with...
Long-term renal function after partial nephrectomy (PN) is difficult to predict as it influenced by several modifiable and nonmodifiable variables, often intertwined in complex relations.To identify variables influencing long-term PN assess their relative weight.A total of 457 patients who underwent either robotic (n = 412) or laparoscopic 45) were identified from a multicenter international database.The 1-yr estimated glomerular filtration rate (eGFR) percentage loss (1YPL), defined the...
Since 2014, a new residency program selection process has been established with national examination. The aim of this study was to assess characteristics, career goals, and practice preferences current Italian urology residents.A web-based survey 25 items performed from May 2021 September sent 585 residents. Descriptive analyses were conducted describe the surveys' domains: demographics studies, plans for fellowship training, interest in field, expectations.Four hundred one residents...
Patients frequently use the Web to obtain health information. This trend increased during COVID19 pandemic. We aimed assess quality of Web-based information on robot-assisted radical cystectomy.
Ischemia reperfusion injury (IRI) is one of the most important mechanisms involved in delayed or reduced graft function after kidney transplantation. It a complex pathophysiological process, followed by pro-inflammatory response that enhances immunogenicity and risk acute rejection. Many biologic processes are its development, such as transcriptional reprogramming, activation apoptosis cell death, endothelial dysfunction innate adaptive immune response. Recent evidence has highlighted...
The association between obesity and clinically significant prostate cancer (PCa) is still a matter of debate. In this study, we evaluated the effect body mass index (BMI) on prediction pathological unfavorable disease (UD), positive surgical margins (PSMs), biochemical recurrence (BCR) in patients with localized (≤cT2c) International Society Urological Pathology (ISUP) grade group 1 PCa at biopsy.427 ISUP who have undergone radical prostatectomy BMI evaluation were included. outcome interest...