A5022085034- Pancreatic function and diabetes
- Diabetes and associated disorders
- Diatoms and Algae Research
- Chromosomal and Genetic Variations
- Pluripotent Stem Cells Research
- Metabolism, Diabetes, and Cancer
- Marine Biology and Environmental Chemistry
- Developmental Biology and Gene Regulation
- Zebrafish Biomedical Research Applications
- Genetics, Aging, and Longevity in Model Organisms
- Corneal Surgery and Treatments
- Diabetes Management and Research
- Telomeres, Telomerase, and Senescence
- Galectins and Cancer Biology
- Endoplasmic Reticulum Stress and Disease
- Genomics and Phylogenetic Studies
- Cellular transport and secretion
- Laser Applications in Dentistry and Medicine
- Dental Implant Techniques and Outcomes
- Nerve injury and regeneration
- Congenital heart defects research
- Protist diversity and phylogeny
- Protein Tyrosine Phosphatases
- Epigenetics and DNA Methylation
- Polymer Surface Interaction Studies
TU Dresden
2014-2023
Heinrich Heine University Düsseldorf
2014-2015
Deutsches Diabetes-Zentrum e.V.
2014-2015
German Center for Diabetes Research
2014-2015
Paul Langerhans Institute Dresden
2014-2015
University Hospital Carl Gustav Carus
2015
Howard Hughes Medical Institute
2014
University of Utah
2010
Huntsman Cancer Institute
2010
University of Freiburg
2007
Axolotl limb regeneration is accompanied by the transient induction of cellular senescence within blastema, structure that nucleates regeneration. The precise role this blastemal senescent cell (bSC) population, however, remains unknown. Here, through a combination gain- and loss-of-function assays, we elucidate functions molecular features in vivo. We demonstrate plays positive during axolotl creating pro-proliferative niche supports progenitor expansion blastema outgrowth. Senescent cells...
Axons of the mammalian CNS lose ability to regenerate soon after development due both an inhibitory environment and loss cell-intrinsic factors necessary for regeneration. The complex molecular events required robust regeneration mature neurons are not fully understood, particularly in vivo . To identify genes affecting axon Caenorhabditis elegans , we performed RNAi-based screen defective motor unc-70 /β-spectrin mutants a candidate gene screen. From these screens, identified at least 50...
Significance Insulin is key for control of glucose homeostasis in vertebrates. Insufficient insulin secretion relative to metabolic needs causes diabetes. Pancreatic beta cells store into secretory granules (SGs), which release extracellularly upon fusion with the plasma membrane. SGs exist different functional pools, newly generated being preferentially secreted. Here we show that aged display reduced competence glucose-stimulated microtubule-mediated transport and are disposed within...
Throughout all kingdoms of life, a large number adhesive biomolecules have evolved to allow organisms adhere surfaces underwater. Proteins play an important role in the adhesion numerous marine invertebrates (e.g. mussels, sea stars, urchins) whereas much less is known about biological adhesives from plants, including diatoms. Diatoms are unicellular microalgae that together with bacteria dominate biofilms sunlit habitats. In this study we present first proteomics analyses diatom material...
Abstract Telomere shortening places a key limitation on cell proliferation 1 . In all vertebrates explored to date, this is overcome by telomerase-dependent telomere extension. Failure maintain length results in premature ageing and functional impairments highly replicative populations as telomeres erode 2 Alternative lengthening of (ALT), telomerase-independent mechanism, compensates for loss subset human cancer lines Here, we demonstrate that the regenerative newt Pleurodeles waltl lacks...
Renowned for their regenerative abilities, axolotls also exhibit exceptional longevity, resistance to age-related diseases and apparent lack of physiological declines through lifespan, have thus been considered organisms negligible senescence. Whether display epigenetic hallmarks ageing remains unknown. Here, we probe the axolotl DNA methylome throughout lifespan present its first clocks. Both at tissue-specific or pan-tissue levels, clocks are biphasic, capable predicting age during early...
f The type 1 diabetes autoantigen ICA512/IA-2/RPTPN is a receptor protein tyrosine phosphatase of the insulin secretory granules (SGs) which regulates size granule stores, possibly via cleavage/signaling its cytosolic tail.The role extracellular region remains unknown.Structural studies indicated that b2or b4-strands in mature ectodomain (ME ICA512) form dimers vitro.Here we show ME ICA512 prompts proICA512 dimerization endoplasmic reticulum.Perturbation b2-strand N-glycosylation upon S508A...
SUMMARY Axolotl limb regeneration is accompanied by the transient induction of cellular senescence within blastema, structure which nucleates regeneration. The precise role this blastemal senescent cell (bSC) population, however, remains unknown. Here, through a combination gain- and loss-of-function assays, we elucidate functions molecular features in vivo . We demonstrate that plays positive during axolotl regeneration, creating pro-proliferative niche supports progenitor expansion...
Introduction: Glucose entry in pancreatic β-cells triggers insulin secretion and the biosynthesis of secretory granules (SGs). Previously we showed that glucose cAMP independently promote binding PTBP1 to mRNAs for proteins, thus enhancing their stability translation. is also key IRES-mediated translation picornaviruses, including coxsackieviruses B (CVB). It has been suggested CVB infection may trigger or precipitate type 1 diabetes. Since required both picornaviruses most T1D autoantigens...
Introduction: Insulin secretion is required for regulation of glucose homeostasis and its impairment leads to diabetes. produced by the pancreatic b-cells, it stored within insulin secretory granules (SGs) released upon stimulation. Newly synthesized preferentially mobile SGs are more prone undergo exocytosis. This suggests that SG age mobility key factors affecting secretion.
Introduction: The receptor protein tyrosine phosphatase ICA512/IA-2/RPTPN is an integral component of the insulin secretory granules (SGs) and a major autoantigen in type-1 diabetes. Insulin SG stores are reduced to 50% mice lacking ICA512. Calpain-mediated cleavage its cytosolic domain upon exocytosis has been proposed as signaling mechanism for adjusting production size consumption stores. function ICA512 extracellular region, instead, largely unknown. Resolution mature ectodomain (ME...