A5101698093- Asthma and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Spine and Intervertebral Disc Pathology
- Immune Cell Function and Interaction
- Eosinophilic Esophagitis
- Respiratory viral infections research
- Airway Management and Intubation Techniques
- Magnetism in coordination complexes
- Olfactory and Sensory Function Studies
- Sinusitis and nasal conditions
- Influenza Virus Research Studies
- Crystal structures of chemical compounds
- Cervical and Thoracic Myelopathy
- Metal complexes synthesis and properties
- Allergic Rhinitis and Sensitization
- Lung Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Viral Infections and Vectors
- Osteoarthritis Treatment and Mechanisms
- Bone Metabolism and Diseases
- Orthopaedic implants and arthroplasty
Chinese Academy of Sciences
2022
Institut Pasteur of Shanghai
2022
Shanghai Chest Hospital
2022
Shanghai Jiao Tong University
2022
University of Illinois Urbana-Champaign
2021
Fudan University
2019-2020
Union Hospital
2016
Huazhong University of Science and Technology
2016
Union Hospital
2016
Accumulating evidence indicates that miRNAs, a class of small non-coding RNAs, are implicated in the pathogenesis various diseases such as cancer and intervertebral disc degeneration. The aim this study was to investigate expression biological function microRNA-34a In study, assessed nucleus pulposus specimens IL-1β-stimulated cells by real-time polymerase chain reaction. functions were investigated using gain loss experiments dual luciferase reporter assay 293T cells. dramatically...
Abstract Background Organisms have orchestrated coagulation and immune systems. Although a link between inflammation haemostasis has been reported in asthma, the interaction mechanism not completely elucidated. Here, we investigated direct mammalian Methods Mice were administered protease or antigens intranasally to induce airway with without thrombin inhibitors treatment. The effects of its on interleukin (IL)‐33 both vivo vitro. Peripheral blood mononuclear cells (PBMCs) plasma from asthma...
Disorders of immune tolerance may lead to allergic asthma. Group 2 innate lymphoid cells (ILC2s) and inflammatory ILC2s (iILC2s) are key players in The vagus nerve innervating the airways releases acetylcholine or neuropeptides (i.e. calcitonin gene-related peptide) via pulmonary C-fibers (PCFs), which could regulate ILC2 activity upon binding α7 nicotinic receptor (α7nAChR, coded by Chrna7) neuropeptide receptors. Whether how α7nAChR PCFs asthma formation iILC2s poorly understood. We used...
Establishment of immune tolerance is crucial to protect humans against asthma. Promyelocytic leukemia zinc finger (PLZF) an emerging suppressor inflammatory responses. CCL21-CCR7 signaling mediates development. However, whether PLZF and are required for the development asthma unknown. Here, we found that Zbtb16 (coding PLZF) Ccl21 were upregulated in OVA-induced (OT) lungs by RNA-seq. physically interacted with GATA3 its expression was higher GATA3+ Th2 cells ILC2s OT lungs. Zbtb16-knockdown...
Abstract Influenza pandemics with different extent occur every year in the world. It can cause high morbidity and mortality, arouse fear panic public, attract extensive attention worldwide. This paper reviews research progress epidemiological characteristics, detection methods, pathogenesis, treatment prophylactic measures of influenza China. will be helpful for us to understand current situation influenza.
Xintong Feng, Qin Zhang, Fengming Luo, Xiaoju Lei Fangfang Xie, Jiayuan Sun, Shiyue Li
Allergic rhinitis and its impact on asthma (ARIA) has been the most preferred reference for national guidelines. The ARIA 2010 revision is first evidence-based clinical guideline in field of allergies, which great influence world. 2016 continues basic framework revision, focuses six controversial issues treatment allergic rhinitis.It aimed to provide clear informationand systematic patients, clinicians health policy makers. interpretation will help domestic otolaryngologist, respiratory...
Objective: Olfactory impairment is commonly observed in chronic rhinosinusitis with nasal polyps(CRSwNP) and has a significant impact on quality of life. However, the risk factors for olfactory have not been fully understood, whether atopy predisposed to CRSwNP patients remains unclear. The present study aims unveil differences olfaction sinonasal symptoms between without by means hospital-based, cross-sectional survey. Method: In this study, 288 ready sinus surgery were consecutively...
Asthma is a chronic airway inflammatory disease caused by variety of factors.Viral infection (especially respiratory syncytial virus) induced bronchiolitis in infancy has become one the most important factors pathogenesis asthma after childhood, and acute exacerbation adulthood also related to viral infection.The relationship between virus its are still not clear.Recent studies have found that innate lymphoid cells may play an role regulating immune response asthma, progress this field be...
Internet Finance is a new financial business model and gets applied more in China with the development of internet.Although it provides convenient faster service, internet finance also brings system risks to China's market.Especially after IPO failure Ant Group, attentions are focused on regulatory system.The purpose this article study whether over-regulated industry.By reviewing other researches SWOT analysis concludes that Group eligible for IPO.Its need market control risks.But strict...