A5102827391- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Asthma and respiratory diseases
- Respiratory viral infections research
- Pediatric health and respiratory diseases
- Influenza Virus Research Studies
- Respiratory Support and Mechanisms
- Pneumonia and Respiratory Infections
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Urinary Tract Infections Management
- Respiratory and Cough-Related Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Autophagy in Disease and Therapy
- Inflammasome and immune disorders
- Complement system in diseases
- Toxin Mechanisms and Immunotoxins
- Toxoplasma gondii Research Studies
- Cardiac Ischemia and Reperfusion
- Viral Infections and Vectors
- Cardiovascular Disease and Adiposity
- Heat shock proteins research
- Cystic Fibrosis Research Advances
- Artificial Intelligence in Healthcare
Fudan University
2017-2025
Shuguang Hospital
2024
Shanghai University of Traditional Chinese Medicine
2024
Abstract Recently, long noncoding RNAs (lncRNAs) have been widely reported to play pivotal roles in the regulation of human cancers. Although oncogenic property lncRNA small nucleolar RNA host gene 3 (SNHG3) has revealed a variety cancers, functions and regulatory mechanism SNHG3 non‐small‐cell lung cancer (NSCLC) remain be investigated. In this study, we detected upregulated expression NSCLC tissues as well cells through quantitative reverse‐transcription polymerase chain reaction (qRT‐PCR)...
Purpose: This study aimed to elucidate the protective mechanism of Traditional Chinese Medicine (TCM) Qifu Yixin formula (QFYXF) improve heart failure (HF) by promoting β-arrestin2 (β-arr2)-mediated SERCA2a SUMOylation. Materials and Methods: The transverse aortic constriction (TAC)-induced HF mice were treated with QFYXF or carvedilol for 8 weeks. β-arr2-KO their littermate wild-type (WT) used as controls. Neonatal rat cardiomyocytes (NRCMs) in vitro. Cardiac function was evaluated...
Allergic asthma is a chronic airway disease characterized by an allergic response and altered immune tolerance. CD4+ tissue-resident memory T (TRM) cells are crucial in the relapsing pathogenesis of asthma. Furthermore, promyelocytic leukemia zinc finger (PLZF) essential transcription factor involved asthmatic tolerance has been implicated regulation CD4+CD44+ cells. However, role TRM tolerance, as well their potential modulation PLZF, remain unclear. Therefore, current study, we explore...
Abstract To investigate the role of TGF-β and IL-6 in myofibroblasts (MFs) — lung cancer cell interactions, cells (Lewis CTM-167 lines) were stimulated by IL-6, MF-conditioned medium (MF-CM) or MFs, with without signaling inhibitor SB431542 and/or JAK2/STAT3 JSI-124. MFs TGF-β, cell-CM cells, Cell proliferation, levels cytokines, expression mRNA protein determined. Mice bearing xenograft tumors intraperitoneally treated JSI-124 monitored for up to 45 days. In co-culture systems, secreted...
Background: Heart failure (HF) has been reported to affect cerebral cortex structure, but the underlying cause not determined. This study used Mendelian randomization (MR) reveal causal relationship between HF and structural changes in cortex. Methods: was defined as exposure variable, structure outcome variable. Inverse-variance weighted (IVW), MR-Egger regression median (WME) were performed for MR analysis; MR-PRESSO Egger's intercept test horizontal pleiotropy; "leave-one-out" sensitivity...
Disorders of immune tolerance may lead to allergic asthma. Group 2 innate lymphoid cells (ILC2s) and inflammatory ILC2s (iILC2s) are key players in The vagus nerve innervating the airways releases acetylcholine or neuropeptides (i.e. calcitonin gene-related peptide) via pulmonary C-fibers (PCFs), which could regulate ILC2 activity upon binding α7 nicotinic receptor (α7nAChR, coded by Chrna7) neuropeptide receptors. Whether how α7nAChR PCFs asthma formation iILC2s poorly understood. We used...
ABSTRACT Excessive secretion of inflammatory factors (cytokine storm) plays a significant role in H1N1-induced acute pneumonia, and autophagy acts as cell-intrinsic mechanism to regulate inflammation. Astragaloside IV (AS-IV), originating from the astragalus root, possesses multiple pharmacological activities, such anti-inflammation. However, influences AS-IV on inflammation have remained elusive. It has been reported that H1N1 infection leads accumulation autophagosomes but obstructs...
Type 2 immune responses are critical for host defense, mediate allergy and Th2-high asthma. The transcription factor, promyelocytic leukemia zinc finger (PLZF), has emerged as a significant regulator of type inflammation in the lung; however, its exact mechanism remains unclear. In this review, we summarized recent findings regarding ability PLZF to control development function innate lymphoid cells (ILCs), iNKT cells, memory T basophils, other that drive responses. We discussed important...
Introduction The aim of the study was to describe psittacosis pneumonia and assess predictive value C-reactive protein/albumin ratio in for severity. Methods Data on cases diagnosed using metagenomic sequencing were collected from three hospitals Shanghai, China Oct. 2019 2022. Serum levels protein albumin measured (CAR) calculated. Spearman’s correlation analysis, ordered logistic regression receiver operating characteristic curve analysis conducted examine ability indicators severity...
Establishment of immune tolerance is crucial to protect humans against asthma. Promyelocytic leukemia zinc finger (PLZF) an emerging suppressor inflammatory responses. CCL21-CCR7 signaling mediates development. However, whether PLZF and are required for the development asthma unknown. Here, we found that Zbtb16 (coding PLZF) Ccl21 were upregulated in OVA-induced (OT) lungs by RNA-seq. physically interacted with GATA3 its expression was higher GATA3+ Th2 cells ILC2s OT lungs. Zbtb16-knockdown...
Clarifying the pathogenesis of asthma and/or identifying specific pathway underlying oral tolerance (OT) would be great significance. In our previous study, promyelocytic leukemia zinc finger (PLZF), which reportedly regulates memory phenotypes, was found to promote ovalbumin (OVA)-induced OT. Therefore, this study aimed explore regulatory effects PLZF on phenotypes in and OT mouse models. We that Zbtb16 (encoding PLZF) PLZF+ cells were highly increased lungs compared with asthmatic lungs....
The role of normal gut microbiota in asthma or ovalbumin (OVA)-induced tolerance (OT) remains unclear. Here, we established mouse models and OT followed by 2 weeks antibiotic treatment, to clear the microbiota. Antibiotic treatment was found alleviate allergic accompanied with a reduction invariant natural killer (iNKT) cells. By RNA-seq analysis, that β-adrenergic receptor (ADRB) genes, including Adrb1 , Adrb2 Adrb3 were downregulated asthmatic lungs, but these changes reversed lungs....
Abstract Influenza pandemics with different extent occur every year in the world. It can cause high morbidity and mortality, arouse fear panic public, attract extensive attention worldwide. This paper reviews research progress epidemiological characteristics, detection methods, pathogenesis, treatment prophylactic measures of influenza China. will be helpful for us to understand current situation influenza.
To investigate the safety profiles of Motherwort injection (MI).A multi-center, prospective and drug- derived hospital intensive monitoring method was conducted to assess MI in real world applications. This study based on a very large population after approved marketed China. All patients using participating hospitals were monitored determine incidence, pattern, severity outcome associated adverse events.The post-marketing surveillance performed 10 094 female from April December, 2015. The...
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<title>Abstract</title> <bold>Objective: </bold>The aim of this retrospective case control study was to investigate the clinical characteristics and outcomes acute excerbations chronic obstuctive pulmonary disease (AECOPD) patients between different gender. <bold>Methods: </bold>We collect first hospitalization who were diagnosed as AECOPD 1 January 2019 31 December 2021 from general ward intensive care unit in hole hospital, Shanghai Fifith Peoples Hospital, Fudan University. Demographic...
<title>Abstract</title> Aims This study aims to investigate the correlation between (TyG) index and progression of atherosclerosis endothelial dysfunction. Methods We retrospectively collected data from 150 adult inpatients with who received consistent medical care at Cardiovascular Department Shuguang Hospital, affiliated Shanghai University Traditional Chinese Medicine, January 2018 December 2023. The TyG was calculated by using formula = ln[triglyceride (TG) [mg/dL] × fasting blood...
Respiratory syncytial virus (RSV) infection is correlated with the chronic pathogenesis and exacerbation of asthma. However, mechanism remains unclear. In this study, acute memory (Mem) asthma models early RSV are established to explore persistence effects on Intravascular injection an anti-CD45 antibody performed define CD4
The aim of this retrospective cohort study was to investigate the clinical characteristics and outcomes acute exacerbations chronic obstructive pulmonary disease (AECOPD) patients between different sex. We aimed collect first hospitalization who were diagnosed as AECOPD 1 January 2019 31 December 2021 from general ward intensive care unit in hole hospital, Shanghai Fifth People's Hospital, Fudan University. Demographic data, initial symptoms, on-admission vital signs, comorbidities,...
A 52-year-old woman presented with respiratory symptoms of productive cough and shortness breath. She had suffered from repeated pneumonia. The CT scans revealed chronic sinusitis, tree bud signs in pulmonary imaging, situs inversus. received a primary diagnosis Kartagener syndrome ciliary dyskinesia (PCD) genetic examination was performed. Compound heterozygous mutations dynein axonemal heavy chain 9 (DNAH9) were identified, which encoded outer arms (ODAs) components. DNAH9 are relatively...