A5032876323- Cancer, Lipids, and Metabolism
- Fatty Acid Research and Health
- Nutritional Studies and Diet
- Diet and metabolism studies
- Regulation of Appetite and Obesity
- Cancer-related Molecular Pathways
- Nutrition, Genetics, and Disease
- Carcinogens and Genotoxicity Assessment
- Adipose Tissue and Metabolism
- Edible Oils Quality and Analysis
- Cancer-related molecular mechanisms research
- Metabolism, Diabetes, and Cancer
- Consumer Attitudes and Food Labeling
- Biochemical Analysis and Sensing Techniques
- Metabolomics and Mass Spectrometry Studies
- Antioxidant Activity and Oxidative Stress
- Cholesterol and Lipid Metabolism
- Peroxisome Proliferator-Activated Receptors
- Estrogen and related hormone effects
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Molecular Biology Techniques and Applications
- Peptidase Inhibition and Analysis
- PI3K/AKT/mTOR signaling in cancer
- Eating Disorders and Behaviors
Universitat Autònoma de Barcelona
2011-2024
Cancer Research UK Cambridge Center
2012
Institute for Biotechnology and Bioengineering
2012
Hospital General de Granollers
2002
Abstract Context.—The dimethylbenz(α)anthracene (DMBA) breast cancer model induced in the rat is used for study of mammary carcinogenesis because it closely mimics human disease. Objective.—To analyze histopathologic features carcinomas DMBA experimental model, a manner similar to that pathology, allow comparative analysis between both systems. Design.—Three series 20 animals were used. At 53 days age, single dose 5 mg per was given. Mammary tumors collected when rats killed. Several...
Disruption of epigenetic patterns is a major change occurring in all types cancers. Such alterations are characterized by global DNA hypomethylation, gene-promoter hypermethylation and aberrant histone modifications, may be modified environment. Nutritional factors, especially dietary lipids, have role the etiology breast cancer. Thus, we aimed to analyze influence different high fat diets on methylation modifications rat dimethylbenz(a)anthracene (DMBA)-induced cancer model. Female...
Effects of a high virgin olive oil diet on the promotion stage dimethylbenz(alpha)anthracene-induced mammary carcinogenesis in rats were investigated comparison with those corn diet. Animals randomly placed into 4 groups: control, fed normolipidic control (3% oil); M, (20%); O, plus 17% and MO, after 33 days Whereas clearly stimulated carcinogenesis, reducing latency time increasing tumor incidence, multiplicity volume, led to lower incidence than former group, similar that volume even...
Adolescents show one of the highest rates ultra-processed foods and drinks (UPF) consumption, studies indicate an association between their consumption internalizing problems. We aim to investigate whether UPF associates with dysfunctions in other psychosocial domains, as well sex effects. In 560 Spanish adolescents (14–17 years old), we assessed products consumed previous day, fruits vegetables (servings/day), physical activity (days/week). Psychosocial functioning (total subscales) was...
In previous studies, we demonstrated that high corn oil diets promote the development of 7,12-dimethylbenz(alpha)anthracene (DMBA)-induced mammary tumors. this study, have investigated whether modulation gene expression is one mechanisms by which high-fat diet exerts such effects. Female Sprague-Dawley rats were induced with DMBA and fed normolipidic (3% oil) or (20% diet. Screening genes differentially expressed in adenocarcinomas from group compared to control was performed cDNA...
Extra-virgin olive oil (EVOO) has been hypothesized to have chemopreventive effects on breast cancer, unlike high corn (HCO) diets that stimulate it. We investigated mechanisms of these differential modulatory actions experimental mammary cancer. In 7,12-dimethylbenz(a)anthracene adenocarcinomas rats fed a EVOO, HCO and control ( n = 20 for each group), we analyzed the expression activity ErbB receptors, p21Ras its extracellular signal-regulated kinase (ERK) 1/2, Akt RalA/B effectors by...
Based on the importance of early-life events in breast cancer risk, we have investigated effects high-fat diets maturation, mammary gland development, and its susceptibility to transformation. Female Sprague-Dawley rats were fed a lowfat (LF), high corn oil (HCO), or extra-virgin olive (HOO) diet from weaning gavaged with 7,12-dimethylbenz[a]anthracene. Body weight mass increased HCO group compared LF group. The vaginal opening was advanced both groups, especially This also had body around...
High extra-virgin olive oil (EVOO) and corn diets differentially modulate experimental mammary carcinogenesis. We have investigated their influence on the initiation stage through modulation of expression xenobiotic-metabolizing enzymes (XMEs) in liver gland. Female Sprague–Dawley rats were fed a low-fat (LF), high (HCO), or EVOO (HOO) diet from weaning gavaged with 7,12-dimethylbenz(a)anthracene (DMBA). The HCO increased mRNA levels phase I CYP1A1, CYP1A2 and, to lesser extent, CYP1B1,...
Nutritional factors, especially dietary lipids, may have a role in the etiology of breast cancer. We aimed to analyze effects high-fat diets on susceptibility mammary gland experimental malignant transformation.Female Sprague-Dawley rats were fed low-fat, high-corn-oil, or high-extra-virgin olive oil (EVOO) diet from weaning induction. Animals induced with 7,12-dimethylbenz[a]anthracene at 53 days and euthanized 36, 51, 100 246 days. Gene expression profiles glands determined by microarrays....