A5041734011- Renal and related cancers
- Pluripotent Stem Cells Research
- Sperm and Testicular Function
- Sexual Differentiation and Disorders
- Testicular diseases and treatments
- Cancer Research and Treatments
- Reproductive Biology and Fertility
- Epigenetics and DNA Methylation
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Gunma University
2024
Yokohama National University
2018-2023
Suzuki (Japan)
2023
Spontaneous testicular teratomas (STTs) derived from primordial germ cells (PGCs) in the mouse embryonic testes predominantly develop 129 family inbred strain. Ter (spontaneous mutation) is a single nucleotide polymorphism that generates premature stop codon of Dead end1 (Dnd1) and increases incidence STTs genetic background. We previously found DND1 interacts with NANOS2 or NANOS3 these complexes play vital role male adult spermatogonia. However, following are unclear: (a) whether works to...
Spontaneous testicular teratomas (STTs) are tumours comprising a diverse array of cell and tissue types, which derived from pluripotent stem-like cells called embryonal carcinoma (ECCs). Although mouse ECCs originate primordial germ (PGCs) in embryonic testes, the molecular basis underlying ECC development remains unclear. This study shows that conditional deletion Dead end1 (Dnd1) migrating PGCs leads to STT development. In Dnd1-conditional knockout (Dnd1-cKO) embryos, colonise testes but...
Abstract The large intestine has a dense milieu of indigenous bacteria, generating complex ecosystem with crosstalk between individual bacteria and host cells. In vitro cell modeling bacterial interactions at the anaerobic interphase have elucidated molecular basis. Although classical lines derived from patients colorectal cancer including Caco-2 cells are used, whether they adequately mimic normal colonic epithelial physiology is unclear. To address this, we performed transcriptome...
<title>Abstract</title> Spontaneous testicular teratomas (STTs) are tumours comprising a diverse array of cell and tissue types, which derived from pluripotent stem-like cells called embryonal carcinoma (ECCs). Although mouse ECCs originate primordial germ (PGCs) in embryonic testes, the molecular basis underlying ECC development remains unclear. This study shows that conditional deletion Dead end1 (<italic>Dnd1</italic>) migrating PGCs leads to STT development....