A5018313564- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- Hemoglobin structure and function
- Cancer, Hypoxia, and Metabolism
- Respiratory Support and Mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Banana Cultivation and Research
- Metabolism and Genetic Disorders
- High Altitude and Hypoxia
- S100 Proteins and Annexins
- Biochemical Analysis and Sensing Techniques
- Seed Germination and Physiology
- Advanced Chemical Sensor Technologies
- Genetics and Plant Breeding
- Metabolomics and Mass Spectrometry Studies
- Carbohydrate Chemistry and Synthesis
- Plant Micronutrient Interactions and Effects
- Chemical Synthesis and Analysis
- Meat and Animal Product Quality
- Genomics and Phylogenetic Studies
- Advanced Proteomics Techniques and Applications
- Childhood Cancer Survivors' Quality of Life
- Neonatal Respiratory Health Research
- Immune cells in cancer
- Bacterial Genetics and Biotechnology
KU Leuven
2014-2024
Vlaams Instituut voor Biotechnologie
2023-2024
VIB-KU Leuven Center for Cancer Biology
2017-2023
Rationale: COPD (Chronic Obstructive Pulmonary Disease) is a disease characterized by persistent airway inflammation and disordered macrophage function. The extent to which alterations in bioenergetics contribute impaired antioxidant responses pathogenesis has yet be fully delineated. Objectives: Through the study of alveolar (AM) peripheral monocyte-derived (MDM) macrophages, we sought establish if intrinsic defects core metabolic processes drive dysfunction redox imbalance. Methods: AM MDM...
Background: Acute respiratory distress syndrome (ARDS) is a severe critical condition with high mortality that currently in focus given it associated caused by coronavirus disease 2019 (COVID-19). Neutrophils play key role the lung injury characteristic of non-COVID-19 ARDS and there also accumulating evidence neutrophil mediated patients who succumb to infection acute 2 (SARS-CoV-2). Methods: We undertook functional proteomic metabolomic survey circulating populations, comparing COVID-19...
<ns3:p><ns3:bold>Background: </ns3:bold>Acute respiratory distress syndrome (ARDS) is a severe critical condition with high mortality that currently in focus given it associated caused by coronavirus disease 2019 (COVID-19). Neutrophils play key role the lung injury characteristic of non-COVID-19 ARDS and there also accumulating evidence neutrophil mediated patients who succumb to infection acute 2 (SARS-CoV-2).</ns3:p><ns3:p> <ns3:bold>Methods: </ns3:bold>We undertook functional proteomic...
Limiting dysfunctional neutrophilic inflammation while preserving effective immunity requires a better understanding of the processes that dictate neutrophil function in tissues. Quantitative mass-spectrometry identified how inflammatory murine neutrophils regulated expression cell surface receptors, signal transduction networks, and metabolic machinery to shape phenotypes response hypoxia. Through tracing labeled amino acids into enzymes, proinflammatory mediators, granule proteins, we...
Zeamine assembly involves nonribosomal peptide, polyketide and polyunsaturated fatty acid-like biosynthetic pathways.
Neutrophils are essential in the early innate immune response to pathogens. Harnessing their antimicrobial powers, without driving excessive and damaging inflammatory responses, represents an attractive therapeutic possibility. The neutrophil population is increasingly recognised be more diverse malleable than was previously appreciated. Hypoxic signalling pathways known regulate important behaviours and, as such, potential targets for regulating responses.
Summary Understanding the mechanisms by which infection with SARS-CoV-2 leads to acute respiratory distress syndrome (ARDS) is of significant clinical interest given mortality associated severe and critical coronavirus induced disease 2019 (COVID-19). Neutrophils play a key role in lung injury characteristic non-COVID-19 ARDS, but relative paucity these cells observed at post-mortem tissue patients who succumb SARS-CoV-2. With emerging evidence dysregulated innate immune response COVID-19,...
Here, we present the data from an in-depth analysis of HSP70 family in non-model banana during osmotic stress [1]. First, a manual curation sequences genome was performed and updated on Musa hub http://banana-genome.cirad.fr/. These curated protein were then introduced into our in-house Mascot database for look at profiles meristem cultures roots stress. A 2D-DIGE LC MS/MS approach chosen to identify quantify different paralogs allelic variants spots.
<ns4:p>Background Neutrophils are essential in the early innate immune response to pathogens. Harnessing their antimicrobial powers, without driving excessive and damaging inflammatory responses, represents an attractive therapeutic possibility. The neutrophil population is increasingly recognised be more diverse malleable than was previously appreciated. Hypoxic signalling pathways known regulate important behaviours and, as such, potential targets for regulating responses. Methods We used...
<h3>Introduction and objectives</h3> Acute Respiratory Distress Syndrome (ARDS) is characterised by neutrophil driven alveolar vascular injury. Alveolar damage associated with worsening hypoxia increased mortality. Specific therapies targeting neutrophilic inflammation are lacking, in part due to the challenge of limiting pathological while preserving immunity. We sought characterise effect on ARDS define mechanisms underlying hypoxic phenotype. <h3>Methods</h3> used a mouse model...