Max Head Fourman
A5040000412- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Sepsis Diagnosis and Treatment
- interferon and immune responses
- Respiratory Support and Mechanisms
- RNA modifications and cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Diabetes and associated disorders
- Respiratory viral infections research
- RNA and protein synthesis mechanisms
- Genetic Associations and Epidemiology
- Immune responses and vaccinations
- Cancer Immunotherapy and Biomarkers
- Endoplasmic Reticulum Stress and Disease
- Genomics and Rare Diseases
- Signaling Pathways in Disease
- Machine Learning in Bioinformatics
- Pneumonia and Respiratory Infections
- Liver Disease Diagnosis and Treatment
- Thermal Regulation in Medicine
University of Edinburgh
2020-2023
Roslin Institute
2020-2023
Edinburgh Royal Infirmary
2020-2021
Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with may identify mechanistic targets for therapeutic development3. Here we report results of GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study 2,244 critically ill patients COVID-19 from 208 UK intensive care units. We have identified replicated following new significant associations: on...
Abstract Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care 1 or hospitalization 2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics Mortality in Care) study enables comparison genomes from individuals who are critically ill those population controls to find underlying disease mechanisms. Here we use whole-genome sequencing 7,491 compared 48,400 discover and replicate 23...
Abstract The subset of patients who develop critical illness in Covid-19 have extensive inflammation affecting the lungs 1 and are strikingly different from other patients: immunosuppressive therapy benefits critically-ill patients, but may harm some non-critical cases. 2 Since susceptibility to life-threatening infections immune-mediated diseases both strongly heritable traits, we reasoned that host genetic variation identify mechanistic targets for therapeutic development Covid-19. 3...
Background: Acute respiratory distress syndrome (ARDS) is a severe critical condition with high mortality that currently in focus given it associated caused by coronavirus disease 2019 (COVID-19). Neutrophils play key role the lung injury characteristic of non-COVID-19 ARDS and there also accumulating evidence neutrophil mediated patients who succumb to infection acute 2 (SARS-CoV-2). Methods: We undertook functional proteomic metabolomic survey circulating populations, comparing COVID-19...
<ns3:p><ns3:bold>Background: </ns3:bold>Acute respiratory distress syndrome (ARDS) is a severe critical condition with high mortality that currently in focus given it associated caused by coronavirus disease 2019 (COVID-19). Neutrophils play key role the lung injury characteristic of non-COVID-19 ARDS and there also accumulating evidence neutrophil mediated patients who succumb to infection acute 2 (SARS-CoV-2).</ns3:p><ns3:p> <ns3:bold>Methods: </ns3:bold>We undertook functional proteomic...
Despite extensive global research into genetic predisposition for severe COVID-19, knowledge on the role of rare host variants and their relation to other risk factors remains limited. Here, 52 genes with prior etiological evidence were sequenced in 1,772 COVID-19 cases 5,347 population-based controls from Spain/Italy. Rare deleterious TLR7 present 2.4% young (<60 years) no reported clinical (n = 378), compared 0.24% (odds ratio [OR] 12.3, p 1.27 × 10
Summary Understanding the mechanisms by which infection with SARS-CoV-2 leads to acute respiratory distress syndrome (ARDS) is of significant clinical interest given mortality associated severe and critical coronavirus induced disease 2019 (COVID-19). Neutrophils play a key role in lung injury characteristic non-COVID-19 ARDS, but relative paucity these cells observed at post-mortem tissue patients who succumb SARS-CoV-2. With emerging evidence dysregulated innate immune response COVID-19,...
Abstract The increasing body of literature describing the role host factors in COVID-19 pathogenesis demonstrates need to combine diverse, multi-omic data evaluate and substantiate most robust evidence inform development therapies. Here we present a dynamic ranking genes implicated human betacoronavirus infection (SARS-CoV-2, SARS-CoV, MERS-CoV, seasonal coronaviruses). Researchers can search review ranked contribution different experimental methods gene rank at...