A5003866488- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Mechanical Circulatory Support Devices
- Pulmonary Hypertension Research and Treatments
- Transplantation: Methods and Outcomes
- Cardiac Structural Anomalies and Repair
- Blood Pressure and Hypertension Studies
- Cardiac Valve Diseases and Treatments
- Pharmaceutical Practices and Patient Outcomes
- Organ Transplantation Techniques and Outcomes
- Cardiomyopathy and Myosin Studies
- Atrial Fibrillation Management and Outcomes
- Hormonal Regulation and Hypertension
- Pharmaceutical Economics and Policy
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Protein Tyrosine Phosphatases
- Cardiac electrophysiology and arrhythmias
- Cellular transport and secretion
- Infective Endocarditis Diagnosis and Management
- Organ Donation and Transplantation
- Cardiac Arrhythmias and Treatments
- RNA regulation and disease
- Tuberculosis Research and Epidemiology
- Endoplasmic Reticulum Stress and Disease
Maternity and Children's Hospital
2025
King Saud University
2016-2025
King Abdullah Medical City
2017
King Faisal Specialist Hospital & Research Centre
2009-2014
Brigham and Women's Hospital
2009
Background: Direct oral anticoagulants (DOACs) have emerged as non-inferior and effective alternatives to traditional in managing thromboembolic risks associated with various cardiovascular conditions. This position statement by the Saudi Heart Association (SHA) aims provide guidance on use of DOACs context disease, particularly patients arterial venous thrombosis.
Hypertension is a highly prevalent disease in Saudi Arabia with poor control rates. Updated guidelines are needed to guide the management of hypertension and improve treatment outcomes.
Dilated cardiomyopathy (DCM) is a common form of causing systolic dysfunction and heart failure. Rare variants in more than 30 genes, mostly encoding sarcomeric proteins the cytoskeleton, have been implicated familial DCM to date. Yet, majority remain be identified. The goal study identify novel mutations dilated cardiomyopathy. We FBXO32 (ATROGIN 1), member F-Box protein family, as DCM-causing locus. missense mutation affects highly conserved amino acid predicted severely impair binding SCF...
Heart failure is associated with the reactivation of a fetal cardiac gene programme that has become hallmark hypertrophy and maladaptive ventricular remodelling, yet mechanisms regulate this transcriptional reprogramming are not fully understood. Using mice genetic ablation calcium/calmodulin-dependent protein kinase II δ (CaMKIIδ), which resistant to pathological stress, we show CaMKIIδ regulates phosphorylation histone H3 at serine-10 during pressure overload hypertrophy. S10 strongly...
Abstract Endoplasmic reticulum (ER) stress induction of cell death is implicated in cardiovascular diseases. Sustained activation ER-stress induces the unfolded protein response (UPR) pathways, which turn activate three major effector proteins. We previously reported a missense homozygous mutation FBXO32 ( MAFbx, Atrogin-1 ) causing advanced heart failure by impairing autophagy. In present study, we performed transcriptional profiling and biochemical assays, unexpectedly revealed reduced UPR...
Aim: The heart function assessment registry trial in Saudi Arabia (HEARTS) is a national multicenter project that compared de novo versus acute-on-chronic failure (ACHF). Methods and Results: This prospective 18 hospitals between October 2009 December 2010. study enrolled 2610 patients: 940 (36%) 1670 (64%) ACHF. Patients with ACHF were significantly older (62.2 vs 60 years), less likely to be males (64% 69%) or smokers (31.6% 36.7%), more have history of diabetes mellitus (65.7% 61.3%),...
Diastolic dysfunction is a recognized complication in heart transplant (HTx) recipients that limits exercise capacity and risk factor for mortality. We investigated the ability of echocardiography to detect elevated pulmonary capillary wedge pressure (mean PCWP>15 mmHg) HTx recipients. This retrospective study comprised with right catheterization within 24 hours (n = 100, 113 investigations). Echocardiographic assessment was performed using mitral inflow (E/A ratio, deceleration time [DT],...
Abstract The low molecular weight protein tyrosine phosphatase (LMPTP), encoded by the ACP1 gene, is a ubiquitously expressed whose in vivo function heart and cardiac diseases remains unknown. To investigate role of LMPTP function, we generated mice with genetic inactivation Acp1 locus studied their response to long‐term pressure overload. −/− develop normally ageing do not show pathology major tissues under basal conditions. However, are strikingly resistant overload hypertrophy failure....
Hypertension (previously called Saudi Advisory Group for Pulmonary Hypertension) has published the first guidelines on diagnosis and treatment of pulmonary arterial hypertension (PAH) back in 2008. [1]That guideline was very detailed extensive reviewed most aspects (PH).
<h3>Objectives:</h3> To understand the attitudes of Saudi population towards heart donation and transplantation. <h3>Methods:</h3> A survey using a questionnaire addressing organ transplantation was conducted across 18 cities in Arabia between September 2015 March 2016. <h3>Results:</h3> total 1250 respondents participated survey. Of these, approximately 91% agree with concept but 17% do not transplantation; 42.4% whom reject transplants for religious reasons. Only 43.6% expressed...
Heart failure (HF) patients place a heavy burden on the healthcare system because of their frequent need for in-patient treatment, emergency room visits and subsequent hospital stays. To provide proper care effective therapy, practitioners have streamlined delivery techniques such as clinical pathways, checklists pocket manuals. However, description establishment disease-management programme, including multidisciplinary team physicians, pharmacists nurse specialists is required. The aim this...
Effect of atrial fibrillation (AF) on short- and long-term outcomes in heart failure (HF) is controversial. Accordingly, we examined this relationship a national multicenter project using data from the Hearts Function Assessment Registry Trial Saudi Arabia that studied clinical features patients admitted with de novo acute chronic HF. Out 2593 HF, 449 (17.8%) had AF at presentation. Patients were more likely to be males older (mean age 65.2 ± 15.0 vs 60.5 14.8 years) have history ventricular...
Pulmonary hypertension (PH) due to left heart disease is the most common cause of pulmonary in western world. It classified as WHO PH group II. Different pathophysiologic abnormalities may take place this condition, including venous congestion and vascular remodeling. Despite high prevalence 2 PH, major focus research on over past decade has been 1 arterial (PAH). Few investigators have focused PH; consequently, pathophysiology condition remains poorly understood, no specific therapy...
Severe mitral regurgitation (MR) with left ventricular dysfunction portends worse outcomes. Over the course of last two decades, transcatheter repair valve offered an alternative therapeutic modality for those deemed inoperable or high risk. Landmark studies such as Cardiovascular Outcomes Assessment MitraClip Percutaneous Therapy Heart Failure Patients With Functional Mitral Regurgitation and Multicentre Study Valve Repair Device in Secondary trials have shown conflicting results respect to...