A5023295197- Transplantation: Methods and Outcomes
- Cystic Fibrosis Research Advances
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Pulmonary Hypertension Research and Treatments
- Neonatal Respiratory Health Research
- Tracheal and airway disorders
- Organ and Tissue Transplantation Research
- Respiratory viral infections research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Polyomavirus and related diseases
- Tuberculosis Research and Epidemiology
- Advanced biosensing and bioanalysis techniques
- Antibiotic Resistance in Bacteria
- Medical Imaging and Pathology Studies
- Liver Disease and Transplantation
- Vascular Anomalies and Treatments
- Asthma and respiratory diseases
- Dysphagia Assessment and Management
- Cardiac tumors and thrombi
- Gut microbiota and health
- Antibiotic Use and Resistance
- Single-cell and spatial transcriptomics
- HIV/AIDS drug development and treatment
Nationwide Children's Hospital
2025
King Faisal Specialist Hospital & Research Centre
2012-2022
Alfaisal University
2020
Saudi Center for Organ Transplantation
2014-2020
King Abdulaziz Hospital
2009
INTEGRIS Baptist Medical Center
2002-2006
Baylor College of Medicine
1998-1999
Methodist Hospital
1998
Wayne State University
1995
Mucoviscidosis of the respiratory, gastrointestinal, and genitourinary tracts is major pathology in patients with cystic fibrosis (CF), a lethal monogenic panethnic multisystemic disease most commonly identified Caucasians. Currently, measurement immuno reactive trypsinogen dry blood spots (DBSs) gold-standard method for initial newborn screening CF, followed by targeted CF transmembrane regulator (CFTR) mutation analysis, ultimate confirmation abnormally elevated sweat chloride. Previous...
Cystic fibrosis is a genetic pathology characterized by abnormal accumulation of mucus in the respiratory, gastrointestinal, and reproductive tracts, caused mutations CFTR gene. Although classical presentation condition well known, there still need for better characterization metabolic alterations related to cystic different genotypic mutations. We employed untargeted, comprehensive lipidomics blood serum samples investigate lipid metabolism pathology, mutation classes, lung function...
BACKGROUND: Cystic fibrosis (CF) occurs in populations Saudi Arabia and the Gulf area.Approximately 2000 known variants have been identified for CF transmembrane conductance regulator (CTFR) gene.Screening ten of most common can detect 80% alleles.OBJECTIVE: Determine pattern CFTR population Arabia.DESIGN: A retrospective, descriptive.SETTING: Tertiary care center.PATIENTS AND METHODS: We examined medical records 396 confirmed patients all age groups that were positive a variant from period...
A 19-years-old girl was referred for lung transplant due to end stage disease secondary idiopathic bilateral bronchiectasis. Her routine pre evaluation showed normal esophageal high-resolution manometry (HRM) and 24-hours impedance pH monitoring. Four weeks after the sequential transplantation (LTx), she developed dysphagia, chest pain regurgitation, complicated by aspiration pneumonia. Repeated HRM Jackhammer esophagus, delayed gastric emptying abnormal 24-hour monitoring consistent with...
Cystic fibrosis (CF), the most common lethal autosomal recessive disorder among Caucasians, is caused by mutations in CF transmembrane conductance regulator (CFTR) chloride channel gene. Despite significant advances management of patients, novel disease-related biomarkers and therapies must be identified. We performed serum proteomics profiling patients (n = 28) healthy subjects 10) using 2D-DIGE MALDI-TOF proteomic approach. Out a total 198 proteins identified, 134 showed statistically...
Hypertension (previously called Saudi Advisory Group for Pulmonary Hypertension) has published the first guidelines on diagnosis and treatment of pulmonary arterial hypertension (PAH) back in 2008. [1]That guideline was very detailed extensive reviewed most aspects (PH).
Cystic fibrosis (CF) has been reported before in Saudi Arabia and the Gulf area. It found that screening for 10 most common cystic transmembrane conductance regulator (CFTR) mutations can detect 80% of positive CFTR cases.To determine geographic distribution variants 5 regions Arabia.A retrospective chart review all conducted from January 1, 1992 to December 2017.The ten population were as follows: p.Gly473GlufsX54 (17%), p.Phe508del (12%), p.Ile1234Val 3120+1G > A (11%), 711+1G T (9%),...
AROUND THE WORLD REPORT ON TRANSPLANTATION IN MIDDLE EAST DURING COVID-19 PANDEMIC The outbreak of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) has led to global changes in the management transplantation. It been assumed— correctly, as it turned out—that use immunosuppression increases vulnerability and that transmission SARS-CoV-2 could occur from organ donors.1 This report highlights summarizes position transplantation Middle East during this period. KINGDOM OF SAUDI...
Lymphangioleiomyomatosis (LAM) is a rare disease that leads to airways and lymphatic channels obstruction due abnormal smooth muscle proliferation. It presents with dyspnea, pneumothorax or chylothorax. Lung transplantation (LT) has emerged as valuable therapeutic option limited reports. We report case of LAM underwent double LT complicated by refractory bilateral chylothorax which was managed successfully povidone-iodine pleurodesis the addition sirolimus post-transplantation...
Lung transplant guidelines recommend nebulized amphotericin B with or without systemic antifungal agents for fungal prophylaxis. However, formulation, dosing, and frequency vary between studies. We assessed the safety effectiveness of to prevent Aspergillus infection in 2 regimens, ie, twice daily compared 3 times daily.This was a single-center retrospective cohort study. included patients at least 14 years old who underwent lung received alone combination another agent either daily. The...
Studies have shown that pulmonary exacerbations in cystic fibrosis (CF) patients are associated with respiratory viruses. The most common agent causing viral infections CF before the age of 3 years is syncytial virus.To obtain prevalence different types infection and to identify its relation type bacterial infection, (CFTR) mutations function test (PFT).A retrospective charts review 387 all groups who were screened for detection viruses during exacerbation from period January 1, 1984 June...
Prior to the availability of pulmonary arterial hypertension (PAH)-specific therapy, PAH was a dreadful disease with very poor prognosis. Better understanding complex pathobiology has led major therapeutic evolution. International regulatory agencies have approved many specific drugs different pharmacologic pathways and routes administration. In year 2013, two new great potentials in managing been added treatment options, macitentan riociguat. Additional are expected come near future. <br>A...
Brucella is one of the most common zoonotic diseases worldwide. It endemic in Mediterranean basin. pneumonia a rare complication brucellosis that can present with variety clinical and radiological manifestations. was described only once previously setting solid organ transplant. A 32-year-old female from Saudi Arabia cystic fibrosis bronchiectasis presented five weeks after bilateral lung transplant fever cough. Investigation showed high inflammatory markers addition to pulmonary infiltrate...
Tuberculosis is an important opportunist infection that can complicate the posttransplant course of solid-organ transplant recipients. Lung recipients are at higher risk tuberculosis after than other Significant drug-drug interactions between antituberculous medications, especially rifampin, and immunosuppressant medications render treatment in this patient population challenging. Data on management lung with rifamycin-sparing regimens so far limited. Therefore, we evaluated incidence,...