A5102942962- Gut microbiota and health
- Sulfur Compounds in Biology
- RNA modifications and cancer
- Animal Nutrition and Physiology
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Animal Behavior and Welfare Studies
- Meat and Animal Product Quality
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Fibroblast Growth Factor Research
- Eicosanoids and Hypertension Pharmacology
- Nutritional Studies and Diet
- Hydrogen's biological and therapeutic effects
- Angiogenesis and VEGF in Cancer
- Iron Metabolism and Disorders
- MicroRNA in disease regulation
- Nitric Oxide and Endothelin Effects
- Sperm and Testicular Function
- Folate and B Vitamins Research
- FOXO transcription factor regulation
- Circular RNAs in diseases
- Diet and metabolism studies
- Clostridium difficile and Clostridium perfringens research
- Heat shock proteins research
Taihe Hospital
2022-2024
Hubei University of Medicine
2022-2024
Wuhan University of Science and Technology
2024
Institute of Subtropical Agriculture
2017-2023
Chinese Academy of Sciences
2017-2023
First Affiliated Hospital of Nanchang University
2022
Nanchang University
2022
Jiangsu University
2014-2022
Affiliated Hospital of Jiangsu University
2022
Hefei University of Technology
2019-2022
We previously reported that IGFBP7 plays a role in maintaining mRNA stability of oncogenic lncRNA UBE2CP3 by RNA-RNA interaction gastric cancer (GC). Clinical cohort studies had implied an GC. However, the molecular mechanism GC progression remains unknown. In this study, clinical analysis based on two independent cohorts showed was positively associated with poor prognosis and macrophage infiltration Loss-of-function confirmed properties regulating cell proliferation invasion. Mechanismly,...
The aim of this study was to determine the effects long-term Nicotinamide mononucleotide (NMN) treatment on modulating gut microbiota diversity and composition, as well its association with intestinal barrier function. In study, C57BL/6J mice were fed different concentrations NMN, their feces collected for detection 16S rDNA non-targeted metabolites explore NMN metabolites. results revealed that increased abundance butyric acid-producing bacteria (Ruminococcae_UCG-014...
Deregulated lncRNAs play critical roles in tumorigenesis and tumor progression. NR2F1-AS1 is an antisense lncRNA of NR2F1. However, the biological function gastric cancer (GC) remains largely unclear. In this study, we revealed that NR2F1 were both positively correlated with degree malignancy predicted poor prognosis two independent GC cohorts. Besides, can respond to Epithelial-to-mesenchymal transition (EMT) signaling GC, since their expression was increased by TGF-beta treatment decreased...
Crocetin is one of the major active constituents saffron (Crocus sativus L.) which has a reputation for facilitating blood circulation and dispersing stasis in traditional Chinese medicine. However, there little evidence showing relationship between crocetin intake risk gastrointestinal diseases such as colitis. In order to investigate effect on regulation intestinal barrier function microbiota composition, mice were treated with after 3% dextran sulfate sodium (DSS) administration week. We...
The biological function of lncRNA ELF3-AS1 remains largely unknown in cancers. cause SNAI2 overexpression tumor metastasis unclear. molecular mechanisms underlying the high co-expression antisense lncRNAs and adjacent protein-coding genes unclear.RNA-seq, CHIP dual-luciferase reporter assay were performed to identify regulated by SNAI2. MicroRNA-seq RNA-seq studies conducted reveal GC. RNA pulldown CHIRP assays protein that interacts with ELF3-AS1.A total 123 identified be GC sequencing....
Abstract Transforming growth factor beta (TGFβ) signaling plays a critical role in tumorigenesis and metastasis. However, little is known about the biological function of TGFbeta-induced lncRNA cancer. In this study, we discovered novel TG Fbeta- i nduced l nc R NA, termed TGILR , whose cancer remains unknown to date. expression was directly activated by canonical TGFbeta/SMAD3 axis, activation highly conserved Clinical analysis showed that overexpression significant correlation with lymph...
Nicotinamide mononucleotide (NMN) exerts physiological effects in mammals through its conversion to nicotinamide adenine dinucleotide (NAD+). In this study, we established experimental models of colitis by mixing drinking water C57BL/6J mice with dextran sodium sulphate (DSS), and then fed them the same concentration NMN or at time. After treatment, observed improved morphology inflamed intestines, slightly restored length colon, barrier function reduced proinflammatory factors expression...
Serine proteases has been considered to be closely associated with the inflammatory response and tumor progression. As a novel serine protease, biological function of PRSS23 is rarely studied in cancers. In this study, prognostic significance was analyzed two-independent gastric cancer (GC) cohorts. overexpression clinically correlated poor prognosis macrophage infiltration GC patients. Loss-of-function study verified that plays oncogenic role GC. RNA-seq, qRT-PCR, western blotting ELISA...
Background . The study was designed to investigate if H 2 S could inhibit high‐salt diet‐induced renal excessive oxidative stress and kidney injury in Dahl rats. Methods Male salt‐sensitive SD rats were used. Blood pressure (BP), serum creatinine, urea, creatinine clearance rate, 24‐hour urine protein measured. Renal ultra‐ microstructures observed. Collagen‐I ‐III contents the oxidants antioxidants levels tissue detected. Keap1/Nrf2 association Keap1 s‐sulfhydration Results After 8 weeks of...
Abstract Salmonella is considered one of the major foodborne pathogens associated with severe infections. Little attempt has been focused on distribution in retail meats and analysis its phenotypic characteristics Anhui Province. The aim this study was to characterize prevalence serovars, antimicrobial susceptibility, resistance genes, virulence genes recovered from Anhui, China. Out 120 samples collected supermarket chains open‐air markets, 16 (13.3%) were positive for , which enterica...
Abstract The study was designed to investigate the role of endogenous sulfur dioxide (SO 2 ) in collagen remodeling and its mechanisms vascular smooth muscle cells (VSMCs). Overexpression SO synthase aspartate aminotransferase (AAT) 1 or increased levels inhibited I III expressions induced by transforming growth factor (TGF)-β1 VSMCs. In contrast, AAT1 AAT2 knockdown a severe deposition TGF-β1-treated Furthermore, overexpression suppressed procollagen mRNA, upregulated matrix...
Fluorescence imaging the interplay between lipid droplets (LDs) and protein aggregates (PAs) is extremely valuable for elucidating molecular mechanisms of aging. Here, we describe first dual-functional fluorescent probe, LW-1, simultaneously LDs PAs in distinct fluorescence channels to dissect interplaying roles during Notably, based on an intriguing mechanism hydrogen bonds regulating single bond rotation, LW-1 selectively detected a red channel. Meanwhile, another intramolecular charge...
The dysregulated genes and miRNAs in tumor progression can be used as biomarkers for diagnosis prognosis. However, the predicting clinical outcome of gastrointestinal cancer (GIC) are still scarce.Genome-wide association studies were performed to screen optimal prognostic miRNA biomarkers. RNA-seq, Ago-HITS-CLIP-seq, western blotting qRT-PCR assays conducted identify target miR-194. Genome-wide CRISPR-cas9 proliferation screening analysis distinguish passenger gene driver gene.A total 9 GIC...
Journal Article Combined supplementation with Lactobacillus sp. and Bifidobacterium thermacidophilum isolated from Tibetan pigs improves growth performance, immunity, microbiota composition in weaned piglets Get access Yiwen He, He Key Laboratory of Agro-ecological Processes Subtropical Region, Institute Agriculture, Chinese Academy Sciences, Changsha 410125, ChinaHunan Provincial Animal Intestinal Function Regulation, College Life Hunan International Joint Ecology Health, Normal University,...
Cancer/testis (CT) antigens/genes are usually overexpressed in cancers and exhibit high immunogenicity, making them promising targets for immunotherapy cancer vaccines. The role of serine protease PRSS56 remains unknown to date.RNA sequencing studies were performed screen CT genes gastric (GC) colorectal (CRC) cells exposed DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine (5-AZA-CdR). Bioinformatics analysis was conducted analyze the correlation between expression methylation....
The study aimed to examine the protective effect of hydrogen sulfide (H2S) on high-salt-induced oxidative stress and myocardial hypertrophy in salt-sensitive (Dahl) rats. Thirty male Dahl rats 40 SD were included study. They randomly divided into control (Dahl + NS), high salt HS), HS NaHS, NS, HS, NaHS hydroxylamine (HA). Rats NS groups given chow with 0.5% NaCl 0.9% normal saline intraperitoneally daily. Myocardial structure, α-myosin heavy chain (α-MHC) β-myosin (β-MHC) expressions...