A5024606893- Glaucoma and retinal disorders
- Visual perception and processing mechanisms
- Ophthalmology and Visual Impairment Studies
- Retinal Imaging and Analysis
- Epilepsy research and treatment
- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Optical Imaging and Spectroscopy Techniques
- Corneal surgery and disorders
- Neuroscience and Neuropharmacology Research
- Ocular and Laser Science Research
- Drug-Induced Ocular Toxicity
- Pharmacological Effects and Toxicity Studies
- Retinopathy of Prematurity Studies
- Intraocular Surgery and Lenses
- Ophthalmology and Eye Disorders
- Parallel Computing and Optimization Techniques
- Model-Driven Software Engineering Techniques
- Impact of Light on Environment and Health
- Circadian rhythm and melatonin
- Ophthalmology and Visual Health Research
- Neurobiology and Insect Physiology Research
- Optical Polarization and Ellipsometry
- Logic, programming, and type systems
- Cephalopods and Marine Biology
Cardiff University
2010-2025
University of Wales
2001-2003
Aston University
1993-2002
Neurosciences Institute
2002
University of Cologne
2000
Bridge Pharma (United States)
2000
Leicester Royal Infirmary
1999
Lund University
1999
University of Manchester
1995
Manchester Royal Eye Hospital
1995
<h3>OBJECTIVE</h3> To estimate the prevalence of visual field defects in patients taking anticonvulsant drug vigabatrin and to characterise features dysfunction found. <h3>METHODS</h3> Thirty three unselected attending neurology epilepsy clinics were identified as asked attend for neuro-ophthalmic evaluation. A control group 16 with unexposed was also evaluated. Visual fields examined by static perimetry using a Humphrey analyser. Patients underwent detailed ophthalmic examination, various...
Summary: Purpose: Vigabatrin (VGB) therapy is associated with a loss of peripheral vision. The characteristics and prevalence VGB‐attributed visual field (V‐AVFL) risk factors were evaluated in patients epilepsy. Methods: material comprised the fields case notes 88 suspected V‐AVFL (25 spontaneous reports 63 cases from an open‐label extension trial) 42 receiving alternative antiepileptic drugs (AEDs) cross‐sectional study. Results: Forty‐two reliable could not be assigned to known cause...
Case notes of 1113 consecutive new patients referred to a consultant ophthalmologist at district general hospital were reviewed determine the source and efficacy referrals current screening practices practitioners ophthalmic opticians. General initiated referral in 546 cases (49%) opticians 439 (39%). Visual loss or visual disturbance was most important single reason for (345 cases; 31%), followed by suspected glaucoma (145 13%), abnormalities binocular vision (140; 12.5%), disorders eyelids...
The quantification of early retinal ganglion cell damage in ocular hypertension and glaucoma.Thirty subjects under treatment for open-angle glaucoma, 23 with hypertension, 28 healthy a control group were investigated by monocular pattern electroretinogram (ERG), L&M (long medium wavelength) cone ERG, S (short wavelength)-cone ERG. diagnosis glaucoma was based on masked assessment digital stereoscopic optic nerve head images three specialists. fiber layer assessed scanning laser...
Abstract. The influence of the learning effect on outcome automated perimetry was studied as a function eccentricity. sample comprised 20 patients with suspected glaucoma who were all naive to perimetry. Visual field examination right eye followed by that left undertaken each three successive days and after further interval 12 using customised full‐field program Humphrey Field Analyser 630 (stimulus size III). 60 points out an eccentricity 60° interstimulus grid 12°. Global, central,...
Objective: To separate the retinal electrophysiologic markers associated with vigabatrin-attributed visual field loss (VGB-VFL) from those current vigabatrin therapy.
Abstract. The influence of prior perimetric experience on the magnitude both differential sensitivity and short long term fluctuations remains unclear, confounds accurate interpretation visual field data obtained by computer‐assisted perimetry. purpose experiment was to identify quantify any training automated response. full right eye 10 clinically normal, naive subjects examined 8 occasions with Octopus Program 21 (target size 3) days 1–5 inclusive, 15, 16 44. Sensitivity increased serial...
To quantify retinal nerve fiber layer thickness (RNFLT) and macular (MT) in patients exhibiting vigabatrin-attributed visual field loss (VAVFL) to determine the efficacy of these measures as markers damage associated with vigabatrin.This was a prospective cross-sectional observational study involving five groups: Group I, 13 VAVFL; II, 8 exposed vigabatrin but normal fields; III, 14 receiving carbamazepine monotherapy; IV, 20 individuals; V, 7 sodium valproate monotherapy. At one two visits,...
Background/aims The antiseizure medication, vigabatrin, is associated with visual field loss (VAVFL). However, the fields can be challenging to interpret due unfamiliarity characteristics of defect and/or difficulty in obtaining a reliable examination, particularly patients cognitive limitations epilepsy. Two machine-learning pattern recognition algorithms were developed identify VAVFL, objectively. Methods adhered European Medicines Agency-approved protocol for detection VAVFL (Three Zone...
Abstract. The detection of change in the visual field is confounded by factors associated with patient response. Sixteen patients who had previously undergone a training regime automated perimetry over short time period were followed up to evaluate longer term learning and fatigue effects. patients, all attending glaucoma clinic, originally naive perimetry. comprised examination right that left eye Humphrey Field Analyser 630 on each 3 successive days again after an interval 12 days....
Summary: Purpose: The risk factors for visual field loss attributable to vigabatrin (VAVFL) are equivocal. This multinational, prospective, observational study aimed clarify the principal/major VAVFL. Methods: Interim analysis of three groups with refractory partial epilepsy, stratified by age (8–12 years; >12 years) and exposure (VGB). Group I comprised participants treated VGB ≥6 months, II previously months who had discontinued drug III those never VGB. Perimetry was undertaken at...
Summary: Purpose : Symptomatic visual field constriction thought to be associated with vigabatrin has been reported. The current study investigated the fields and electrophysiology of eight patients known vigabatrin‐attributed loss, three whom were reported previously. Six no longer receiving vigabatrin. Methods central peripheral examined Humphrey Visual Field Analyzer. Full electrophysiology, including flash electroretinography (ERG), pattern electroretinography, multifocal ERG using VERIS...