A5100348742- Diabetes Treatment and Management
- Endoplasmic Reticulum Stress and Disease
- Pancreatic function and diabetes
- RNA modifications and cancer
- Cholesterol and Lipid Metabolism
- RNA and protein synthesis mechanisms
- Cancer, Hypoxia, and Metabolism
- Calpain Protease Function and Regulation
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Peroxisome Proliferator-Activated Receptors
- Ferroptosis and cancer prognosis
- Curcumin's Biomedical Applications
- Ubiquitin and proteasome pathways
- Protein Degradation and Inhibitors
- Nitric Oxide and Endothelin Effects
- RNA Research and Splicing
- Diabetes Management and Research
- Cancer, Lipids, and Metabolism
- Diabetes and associated disorders
- Regulation of Appetite and Obesity
- Drug Transport and Resistance Mechanisms
- Pharmacological Effects of Natural Compounds
- interferon and immune responses
- Neuroscience and Neuropharmacology Research
Chiba University
2010-2024
Wellcome/MRC Institute of Metabolic Science
2019
Addenbrooke's Hospital
2019
University of Cambridge
2019
Wellcome Trust
2019
Korea Research Institute of Bioscience and Biotechnology
2016
Ewha Womans University
2012
University of Potsdam
2008
University of Würzburg
2008
Stony Brook University
2008
Abstract Glutamine synthase 2 (GLS2) is a key regulator of glutaminolysis and has been previously implicated in activities consistent with tumor suppression. Here we generated Gls2 knockout (KO) mice that develop late-occurring B-cell lymphomas hepatocellular carcinomas (HCC). Further, KO subjected to the hepatocarcinogenic Stelic Animal Model (STAM) protocol produce larger HCC tumors than seen wild-type (WT) mice. GLS2 shown promote ferroptosis, form cell death characterized by...
Because of mechanistic parallels in the activation ubiquitin and biosynthesis several sulfur-containing cofactors, we have characterized human Urm1 Saccharomyces cerevisiae Uba4 proteins, which are very similar sequence to MOCS2A MOCS3, respectively, two proteins essential for molybdenum cofactor (Moco) humans. Phylogenetic analyses MOCS3 homologues showed that is homologue yeast thus only remaining protein Moco biosynthetic pathway this organism. high levels identity Uba4, purified...
Abstract The liver stores glycogen and releases glucose into the blood upon increased energy demand. Group 2 innate lymphoid cells (ILC2) in adipose pancreatic tissues are known for their involvement homeostasis, but metabolic contribution of ILC2s has not been studied detail. Here we show that directly involved regulation levels. Mechanistically, interleukin (IL)-33 treatment induces IL-13 production ILC2s, while suppressing gluconeogenesis a specific Hnf4a/G6pc-high primary hepatocyte...
Mechanisms of carbohydrate-induced secretion the two incretins namely glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are considered to be mostly similar. However, we found that mice exhibit opposite secretory responses in response co-administration maltose plus an α-glucosidase inhibitor miglitol (maltose/miglitol), stimulatory for GLP-1, as reported previously, but inhibitory GIP. Gut microbiota was shown involved maltose/miglitol-induced GIP...
Abstract Fructose-1,6-bisphosphatase (FBPase) deficiency, caused by an FBP1 mutation, is autosomal recessive disorder characterized hypoglycemic lactic acidosis. Due to the rarity of FBPase mechanism which mutations cause enzyme activity loss still remains unclear. Here we identify compound heterozygous missense FBP1, c.491G>A (p.G164D) and c.581T>C (p.F194S), in adult patient with The G164D F194S mutants exhibit decreased protein expression a activity. biochemical phenotypes all...
본 연구는 나트륨 섭취 저감화를 위한 연구의 일환으로 한국 일부 대학생들의 라면 섭취에 관한 식행동 현황을 설문 조사하고 국물 섭취량을 실측하였다. 2010년 9월부터 12월까지 국내 4개 대학에 재학 중인 347명(남 146명, 여201명)을 대상으로 인스턴트 1개 분량을 제공하면서 후의 양을 측정하였고, 평소 라면섭취에 식행동을 조사하여 다음과 같은 결과를 얻었다. 조사대상자들의 평균 연령은 남자 23.7세, 여자 20.5세였으며, 평균BMI(kg/m2)는 21.9, 20.1이었다. 라면의 섭취빈도는 주 2회였고, 남자가 여자보다 빈도가 높은 경향이 있었다. 라면을 섭취하는 주된 이유는 간편해서 56%, 맛이 좋아서 27%, 가격이 저렴해서 11%, 기타 9%순이었다. 선택 기준으로 맛 72%, 편의 14%, 가격7%, 영양 1%, 2%로 연구 대상자들이 응답하였다. 실제 양 조사에서 남자는 제공된 국물의 61%, 여자는 36%를 섭취하였는데, 측정치가 설문을 통한 평상시...
As glucose-dependent insulinotropic polypeptide (GIP) possesses pro-adipogenic action, the suppression of GIP hypersecretion seen in obesity might represent a novel therapeutic approach to treatment obesity. However, mechanism remains largely unknown. In present study, we investigated secretion two mouse models obesity: High-fat diet-induced obese (DIO) mice and leptin-deficient Lepob/ob mice. DIO mice, plasma was increased along with an increase mRNA expression lower small intestine....
α-cyclodextrin (α-CD) is one of the dietary fibers that may have a beneficial effect on cholesterol and/or glucose metabolism, but its efficacy and mode action remain unclear.In present study, we examined anti-hyperglycemic α-CD after oral loading liquid meal in mice.Administration 2 g/kg suppressed hyperglycemia loading, which was associated with increased glucagon-like peptide 1 (GLP-1) secretion enhanced hepatic sequestration. By contrast, similarly hyperglycemia, without increasing...
Diabetes mellitus is induced by quantitative and qualitative decline in pancreatic β cells. Although its radical therapy has not yet been established, cell regeneration a promising option. We investigate here two mouse models of after ∼80% reduction number: Cre/loxP-mediated ablation partial pancreatectomy. Cre/loxP-mediated, mosaic-pattern diphtheria toxin (DT) prompted rapid replenishment through repeated proliferation rare, highly proliferative DT receptor-negative cells along with increase
Gpr52 is an orphan G-protein-coupled receptor of unknown physiological function. We found that Gpr52-deficient (Gpr52−/−) mice exhibit leanness associated with reduced liver weight, decreased hepatic de novo lipogenesis, and enhanced insulin sensitivity. Treatment the hepatoma cell line HepG2 cells c11, synthetic GPR52 agonist, increased fatty acid biosynthesis, knockdown (KD) abolished lipogenic action c11. In addition, c11 induced expressions enzymes (SCD1 ELOVL6), whereas these inductions...
The aminoacyl-tRNA synthetases (ARSs) are ancient house-keeping enzymes that catalyze the ligation of tRNAs to their cognate amino acids in first step protein synthesis. During evolution higher eukaryotes, cytoplasmic ARSs have undergone significant changes including addition new domains not part enzymatic core. These additional regions been found be associated with a broad range biological functions beyond non-translational appear regulated by presence within multi-tRNA synthetase complex...
Gpr52 is an orphan G-protein-coupled receptor of unknown physiological function. We found that Gpr52-deficient (Gpr52-/-) mice exhibit leanness associated with reduced liver weight, decreased hepatic de novo lipogenesis, and enhanced insulin sensitivity. Treatment HepG2 cells c11, the synthetic GPR52 agonist, increased fatty acid biosynthesis, GPR52-knockdown (KD) abolished lipogenic action c11 without affecting its basal level. In addition, induced gene expressions enzymes (SCD1, ELOVL6,...