Background/Objectives: Fake pain expressions are more intense, prolonged, and include non-pain-related actions compared to genuine ones. Despite these differences, individuals struggle detect deception in direct tasks (i.e., when asked liars). Regarding neural correlates, while observation has been extensively studied, little is known about the distinctions between processing genuine, fake, suppressed facial expressions. This study seeks address this gap using authentic stimuli an implicit...

Abstract Background In Crohn's disease ( CD ) patients, stress is believed to influence symptoms generation. Stress may act via central nervous system pathways affect visceral sensitivity and motility thus exacerbating gastrointestinal symptoms. The neural substrate underpinning these mechanisms needs be investigated in . We conducted an explorative functional magnetic resonance imaging fMRI study order investigate potential differences the brain response patients compared controls. Methods...

EEG slow waves, the hallmarks of NREM sleep are thought to be crucial for regulation several important processes, including learning, sensory disconnection and removal brain metabolic wastes. Animal research indicates that waves may involve complex interactions within between cortical subcortical structures. Conventional in humans, however, has a low spatial resolution is unable accurately describe changes activity deep To overcome these limitations, here we took advantage simultaneous...

Background/Objectives: Olfactory decline is common in normal aging and frequent neurodegenerative diseases such as Alzheimer’s disease (AD). Therefore, it has been suggested a marker for the Mild Cognitive Impairment (MCI) progression to AD. Although suggested, relationship between olfactory deficits cerebral atrophy MCI conversion AD still debated. This study aims at investigating olfaction-related morphological behavioural alterations order understand whether they can predict Methods:...

Introduction Different studies have investigated by means of EEG-fMRI coregistration the brain networks related to generalized spike-and-wave discharges (GSWD) in patients with idiopathic epilepsy (IGE). These revealed a widespread GSWD-related neural network that involves thalamus and regions default mode network. In this study we which are critically involved termination absence seizures (AS) group IGE patients. Methods Eighteen (6 male; mean age 25 years) AS were included study....

Recent neuroimaging studies have investigated the brain involvement in patients with Crohn's disease (CD) and Ulcerative Colitis (UC). Functional found abnormalities cognitive emotional functions CD UC, while a voxel based morphometry (VBM) study morphological changes CD. We conducted VBM to compare gray matter (GM) volume of UC controls.Eighteen remission eighteen healthy controls underwent structural MRI. is fully automated technique allowing identification regional differences amount GM,...

Abstract Background Crohn’s disease (CD) is an inflammatory, chronic disorder that alternates between a quiescent phase and inflammatory flare-ups. Research has begun to elucidate the impact of CD in modulating brain structure function. The previous neuroimaging studies mainly involved patients remission (CD-R); therefore, little known about how inflammation influences brain-related features different stages disease. We carried out magnetic resonance imaging (MRI) study explore whether...

Facial expressions of pain are able to elicit empathy and adaptive behavioral responses in the observer. An influential theory posits that relies on an affective mirror mechanism, according which emotion recognition upon internal simulation motor interoceptive states triggered by emotional stimuli. We tested this hypothesis comparing representations self or others' nineteen young healthy female volunteers means functional magnetic resonance imaging (fMRI). hypothesized one's own facial more...

Disparagement humor is a kind of that denigrates, belittles an individual or social group. In the aim to unveil offensive side these kinds jokes, we have run event-related fMRI study asking 30 healthy volunteers judge level fun series verbal stimuli ended with sentence was socially inappropriate but funny (disparagement joke -DJ), not (SI) neutral (N). Behavioral results showed disparagement jokes are perceived as and at same time offensive. However, offense in DJ lower than registered SI...

According to the Scalar Expectancy Theory, humans are equipped with a biological internal clock, possibly modulated by attention and arousal. Both emotions pain arousing can absorb attentional resources, thus causing distortions of temporal perception. The aims present single-event fMRI study were investigate: a) whether observation facial expressions interferes time production; b) neural network subserving this kind distortions. Thirty healthy volunteers took part in study. Subjects asked...

Background Recent evidence suggests that anosognosia or unawareness of cognitive impairment in Alzheimer’s Disease (AD) may be explained by a disconnection between brain regions involved accessing and monitoring information regarding self others. It has been demonstrated AD patients with have reduced connectivity within the default mode network (DMN) people prodromal is positively associated bilateral anterior cingulate cortex (ACC), suggesting possible role this region mechanisms awareness...

functional and structural MRI studies suggest that the orexin (hypocretin) deficiency in dorso-lateral hypothalamus of narcoleptic patients would influence both brain metabolism perfusion cause reduction cortical grey matter. Previous fMRI have mainly focused on cerebral functioning during emotional processing. The aim present study was to explore hemodynamic behaviour spontaneous BOLD fluctuation at rest with Narcolepsy type 1 (NT1) close disease onset.

Stimuli with negative emotional valence are especially apt to influence perception and action because of their crucial role in survival, a property that may not be precisely mirrored by positive stimuli equal intensity. The aim this study was identify the neural circuits differentially coding for implicit processing facial expressions words, which among main ways human beings use express emotions. Thirty-six healthy subjects took part an event-related fMRI experiment. We used task visual...

Introduction Recent studies have shown that processing semantic pain, such as words associated with physical modulates pain perception and enhances activity in regions of the matrix. A direct comparison between activations due to noxious stimulation conveying may clarify whether what extent neural substrates nociceptive are shared by pain. Pain is triggered also experiences social exclusion, rejection or loss significant others (the so-called pain), therefore expressing modulate similarly...

"Autobiographical memory" (AM) refers to remote memories from one's own life. Previous neuroimaging studies have highlighted that voluntary retrieval processes AM involve different forms of memory and cognitive functions. Thus, a complex widespread brain functional network has been found support AM. The present magnetic resonance imaging (fMRI) study used multivariate approach determine whether neural activity within the circuit would recognize real autobiographical events, evaluate...

Background Recent models of anosognosia in dementia have suggested the existence an implicit component self-awareness about one’s cognitive impairment that may remain preserved and continue to regulate behavioral, affective, responses even people who do not show explicit awareness their difficulties. Behavioral studies used different strategies demonstrate patients with anosognosia, but no neuroimaging yet investigated its neural bases. Methods Patients amnestic mild due Alzheimer’s disease...

Objective: To evaluate local and distant blood oxygen level dependent (BOLD) signal changes related to interictal epileptiform discharges (IED) in drug-resistant temporal lobe epilepsy (TLE). Methods: Thirty-three TLE patients undergoing EEG-functional Magnetic Resonance Imaging (fMRI) as part of the presurgical workup were consecutively enrolled. First, a single-subject spike-related analysis was performed: (a) verify BOLD concordance with presumed Epileptogenic Zone (EZ); (b) investigate...

Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI

Abstract Background Recent evidence suggests that unawareness in Alzheimer’s disease (AD) continuum can be explained by a failure of the connections between brain regions involved accessing and monitoring self other information. It has been demonstrated AD patients with anosognosia have reduced network connectivity default mode (DMN); addition, stronger bilateral anterior cingulate cortex (ACC) was showed to associated prodromal suggesting possible role this region mechanisms “adaptation”...

Facial imitation occurs automatically during the perception of an emotional facial expression, and preventing it may interfere with accuracy emotion recognition. In present fMRI study, we evaluated effect posing a expression on recognition ambiguous expressions. Since activity is affected by various factors, such as empathic aptitudes, Interpersonal Reactivity Index (IRI) questionnaire was administered scores were correlated brain activity. Twenty-six healthy female subjects took part in...

The ability to mental time travel (MTT) consists in moving along a cognitive and spatially oriented representation of time, that is, an ideal line, where past future events are, respectively, located on the left right portion such line. A shift spatial attention by prismatic adaptation (PA) influences this coding thus affecting MTT. Here, we investigated neural correlates modulation MTT functional Magnetic Resonance Imaging protocol.

In this paper, we describe the multimodal MRI findings in a patient with Wilson disease and seizure disorder, characterized by an electroclinical picture resembling juvenile myoclonic epilepsy. The brain structural showed deposition of ferromagnetic materials basal ganglia, marked hypointensities T2-weighted images globus pallidus internus bilaterally. A resting-state fMRI study revealed increased functional connectivity patient, compared to control subjects, following networks: (1) between...