A5011674891- MicroRNA in disease regulation
- Circular RNAs in diseases
- Nuclear Structure and Function
- Clusterin in disease pathology
- Polyomavirus and related diseases
- Bone Metabolism and Diseases
- Rheumatoid Arthritis Research and Therapies
- Virus-based gene therapy research
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Galectins and Cancer Biology
- Herpesvirus Infections and Treatments
- Cytokine Signaling Pathways and Interactions
- Bacteriophages and microbial interactions
- T-cell and B-cell Immunology
- Osteoarthritis Treatment and Mechanisms
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- Human Resource and Talent Management
- Education, Psychology, and Social Research
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Nanoplatforms for cancer theranostics
- Spondyloarthritis Studies and Treatments
Institute of Rheumatology
2016-2018
Charles University
2008-2018
Center for Rheumatology
2018
Czech Academy of Sciences
2014
MicroRNAs (miRNAs) are small RNAs that regulate gene expression by targeting mRNA. It was proved some miRNAs significantly deregulated in rheumatoid arthritis (RA). MicroRNA-125b negatively regulates of TNF-α, which plays a crucial role RA pathogenesis. The aim this study to determine the treatment outcome patients with early based on circulating and cellular miR-125b. Total RNA isolated from plasma peripheral blood mononuclear cells (PBMCs) 58 before three months after initiation 54 age-...
// Veronika Vlková 1 , Ivan Štěpánek Hrušková Filip Šenigl 2 Mayerová Martin Šrámek Jana Šímová Bieblová Marie Indrová Tomáš Hejhal Nicolas Dérian 3,4,5,6 David Klatzmann Adrien Six and Milan Reiniš Department of Tumour Immunology, Institute Molecular Genetics, Academy Sciences the Czech Republic, v. i., Prague Viral Cellular 3 Sorbonne Universités, UPMC Univ Paris 06, UMR 7211, Immunology-Immunopathology-Immunotherapy (I3), Paris, France 4 CNRS, FRE 3632, 5 INSERM, UMR_S 959, 6 AP-HP,...
<h3>Background and objectives</h3> MicroRNAs (miRNAs) are small RNAs that regulate gene expression by targeting mRNA. It was proved some miRNAs significantly deregulated in rheumatoid arthritis (RA). MicroRNA-125b negatively regulates of TNF-α, which plays a crucial role RA pathogenesis. The aim this study to evaluate the miRNA-125b peripheral blood mononuclear cells (PBMCs) its association with disease activity treatment response early patients. <h3>Materials methods</h3> A total 58 (42...
<h3>Background</h3> We have previously shown differential expression of some circulating miRNAs in patients with early RA (ERA) and their potential as markers disease activity treatment response. <h3>Objectives</h3> aimed to investigate differentially expressed clinically suspect arthralgia positive antibodies citrullinated peptide antigens (ACPA) who are at high risk developing compared them ERA established RA. <h3>Methods</h3> The study included 20 ACPA+ patients, 25 naïve met the 2010...
<h3>Background</h3> Clusterin (apolipoprotein J) is an extracellular chaperone involved in the number of biological processes, such as inflammation and apoptosis. Recent data suggest its protective role autoimmune diseases. The aim this study was to analyse serum levels clusterin expression skeletal muscle specimens patients with idiopathic inflammatory myopathies (IIM) vs healthy controls, investigate association disease activity. <h3>Materials methods</h3> were measured by ELISA...
<h3>Background</h3> Individuals with clinically suspect arthralgia (CSA) positivity of anti-citrullinated protein antibodies (ACPA) are considered at high risk developing rheumatoid arthritis (RA). The altered expression miRNAs is involved in the development and maintenance autoimmune diseases. We aimed to investigate differentially expressed peripheral blood mononuclear cells (PBMC) CSA healthy controls (HC). <h3>Material methods</h3> study included 19 20 HC. Disease activity assessments...
<h3>Background</h3> Clusterin (also known as apolipoprotein J) is a molecular chaperone that participates in inflammatory and apoptotic processes. Recent data indicate its possible protective role the development of chronic autoimmune disorders. <h3>Objectives</h3> The aim this study was to analyse skeletal muscle expression clusterin serum levels patients with idiopathic myopathies (IIM) healthy donors, examine association disease activity. <h3>Methods</h3> mRNA specimens, obtained by...
<h3>Introduction</h3> The altered expression of miRNAs is involved in the pathophysiology inflammatory conditions. Moreover, circulating appear promising therapeutic and prognostic biomarkers. <h3>Objectives</h3> To investigate effect anti-TNF therapy on levels patients with ankylosing spondylitis (AS). <h3>Methods</h3> Our study included 19 AS patients. Clinical laboratory parameters disease activity were assessed at baseline (M0) after 3 (M3) 12 months (M12) therapy. Total RNA from plasma...