A5101465809- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Scoliosis diagnosis and treatment
- Bone Tissue Engineering Materials
- Cervical and Thoracic Myelopathy
- Medical Imaging and Analysis
- Graphene and Nanomaterials Applications
- Nanoplatforms for cancer theranostics
- Pelvic and Acetabular Injuries
- Orthopaedic implants and arthroplasty
- Musculoskeletal pain and rehabilitation
- 3D Printing in Biomedical Research
- Spinal Hematomas and Complications
- biodegradable polymer synthesis and properties
- Spinal Cord Injury Research
- Dental Implant Techniques and Outcomes
- Spinal Dysraphism and Malformations
- Additive Manufacturing and 3D Printing Technologies
- Advanced Nanomaterials in Catalysis
- Hip and Femur Fractures
- Human Mobility and Location-Based Analysis
- Speech and Audio Processing
- Colorectal Cancer Surgical Treatments
- Fluoride Effects and Removal
- Polymer Surface Interaction Studies
Sichuan University
2016-2025
West China Hospital of Sichuan University
2016-2025
Zero to Three
2024
Affiliated Hospital of Southwest Medical University
2019-2021
Inform (Germany)
2017
In this work, we developed the first 3D-printed polyetheretherketone (PEEK)-based bone scaffold with multi-functions targeting challenging diseases such as osteosarcoma and osteomyelitis. A PEEK/graphene nanocomposite was deposited a drug-laden (antibiotics and/or anti-cancer drugs) hydroxyapatite coating. The graphene nanosheets within served effective photothermal agents that endowed on-demand conversion function under near-infrared laser irradiation. bioactive coating significantly...
In this study, a novel artificial intervertebral disc implant with modified "Bucklicrystal" structure was designed and 3D printed using thermoplastic polyurethane. The new has unique auxetic building blocks joined "face-to-face". accompanied negative Poisson's ratio enables its excellent energy absorption stability under compression. deformation load distribution behavior of the various loading conditions (bending, torsion, extension flexion) been thoroughly evaluated through finite element...
This study explores the use of chicken egg white (EW), a rich source natural proteins, to address challenges in wound healing management. Herein, novel Zn2+-infused EW/GelMA (EW/Gel) hybrid hydrogel is developed, featuring an interpenetrating network (IPN) structure, where first consists photo-cross-linked GelMA and second EW (Zn-EW) through ion–protein binding. By optimizing design formulation, resulting Zn-EW/Gel exhibited enhanced mechanical stability self-adhesive properties. In vitro...
The use of polyetheretherketone (PEEK) has grown exponentially in the biomedical field recent decades because its outstanding biomechanical properties. However, lack bioactivity/osteointegration remains an unresolved issue toward wide orthopedic applications. In this work, graphene nanosheets have been incorporated into PEEK to obtain multifunctional nanocomposites. Because formation electrical percolation network and π-π* conjugation between PEEK, resulting composites achieved 12 orders...
Intervertebral disc degeneration (IDD) is a major contributing factor to both lower back and neck pain. As IDD progresses, the intervertebral (IVD) loses its ability maintain height when subjected axial loading. This failure in weight-bearing capacity of IVD characteristic feature degeneration. Natural polymer-based hydrogel, derived from biological polymers, possesses biocompatibility able mimic structure extracellular matrix, enabling them support cellular behavior. However, their...
Titanium (Ti) and its alloys have been widely used in clinics as preferred materials for bone tissue repair replacement. However, the lack of biological activity Ti limits clinical applications. Surface modification with bioactive elements has always a research hotspot. In this study, to promote osseointegration Ti6Al4V (Ti64) implants, calcium (Ca), oxygen (O), phosphorus (P) codoped multifunctional micro–nanohybrid coatings were prepared on three-dimensional (3D) printed porous Ti64...
ABSTRACT Objective Pedicle screw loosening is one of the common complications in elderly patients undergoing transforaminal lumbar interbody fusion (TLIF) for spine disease. Malnutrition, prevalent among patients, has been shown to be associated with increased complications. The Geriatric Nutritional Risk Index (GNRI) serves as a simple indicator nutritional status. However, relationship between malnutrition, particularly GNRI, and pedicle not adequately investigated. This study aims...
Abstract Cage subsidence is one of the most common complications after transforaminal lumbar interbody fusion (TLIF) and correlates with inferior bone quality. Studies have reported L1 vertebral quality score (VBQ) based on MRI to be a promising alternative evaluating preoperative However, knowledge authors, no study has examined correlation between VBQ scores cage TLIF. The purpose was (1) assess interrelation TLIF; (2) compare CT Hounsfield Unit (HU) values in predicting We reviewed...
We address the challenge of WiFi-based temporal activity detection and propose an efficient Dual Pyramid Network that integrates Temporal Signal Semantic Encoders Local Sensitive Response Encoders. The Encoder splits feature learning into high low-frequency components, using a novel Signed Mask-Attention mechanism to emphasize important areas downplay unimportant ones, with features fused ContraNorm. captures fluctuations without learning. These pyramids are then combined new cross-attention...
<title>Abstract</title> Purpose This study aimed to compare the effectiveness of modified vertebral bone quality (MVBQ) score and traditional (VBQ) in predicting cage subsidence following transforaminal lumbar interbody fusion (TLIF), using quantitative computed tomography (QCT) for validation. Methods W We performed a retrospective analysis patients who underwent single-level TLIF surgery spinal degeneration between 2014 2022. VBQ MVBQ scores are calculated based on T1-weighted MRI....
Currently, there are limited reports regarding investigation of the biological properties polyetheretherketone (PEEK) coated with titanium (Ti) and hydroxyapatite (HA) in human. The objective this study is to evaluate vivo response PEEK cages Ti HA versus uncoated after anterior cervical discectomy fusion (ACDF) patients single-level degenerative disc disease (CDDD).Twenty-four (PEEK/Ti/HA group) were matched one-to-one (PEEK based on age, gender, operative segment. All had been followed up...
A three-dimensional (3D) printed biodegradable hydrogel scaffold with a strong self-expanding ability to conform the contour of irregular bone defects and be closely adjacent host tissues is reported herein. The has triple cross-linked network structure consisting photo-cross-linked polyacrylamide (PAAM) polyurethane (PU) as primary IPN chemical gelatin (Gel) secondary network, which confers good mechanical properties. addition PU in polymerization process acrylamide (AAM) can improve...
Previous studies have confirmed that intervertebral disc degeneration (IDD) is closely associated with inflammation-induced reactive oxygen species (ROS) and resultant cell mitochondrial membrane potential (MMP) decline. Clearance of ROS in an inflammatory environment essential for breaking the vicious cycle MMP Additionally, re-energizing mitochondria damaged milieu to restore their function, equally important. Herein, we proposed interesting concept mitochondrion-engine equipped coolant,...
The design and fabrication of NO-evolving core-shell nanoparticles (denoted as NC@Fe), comprised BNN6-laden COF@Fe