Kidney renal papillary cell carcinoma (KIRP) is a common type of carcinoma. DNA methylation plays an important role in the development several cancers. The aim our study was to identify differentially expressed genes associated with abnormal as biomarkers for predicting outcome KIRP.We downloaded KIRP data, RNA sequencing (RNAseq) and their corresponding clinical information from Cancer Genome Atlas (TCGA) database. ChAMP DEGseq2 packages R software were used screen methylated probes (DMPs)...

Background: Ferroptosis is a novel regulated cell death that characterized by iron-dependent oxidative damage. Renal cancer the second most common of urinary system, which highly correlated with iron metabolism. The aim our present study was to identify suitable ferroptosis-related prognosis signatures for renal cancer. Methods: We downloaded RNA-seq count data from Cancer Genome Atlas database and used DESeq2, Survival, Cox regression analyses screen signatures. Results: identified 5...

Early-onset colorectal cancer (EOCRC) was characterized by strong aggressiveness and high malignancy. The aim of this study to screen suitable biomarkers for patients with EOCRC. EOCRC from Cancer Genome Atlas Program (TCGA) database Gene Expression Mapping (GEO) were used prognosis treatment guidance. Clinical samples verify the expression situation these candidate biomarkers. results showed immune-related gene nitric oxide synthase 2 (NOS2) independently associated poor in both TGCA GEO...

Ferroptosis is a recently recognised new type of cell death which may be potential target for cancer therapy. In the present study, we aimed to screen ferroptosis-related differentially expressed long non-coding RNAs as biomarkers predict outcome kidney renal clear carcinoma.RNAseq count data and corresponding clinical information were obtained from Cancer Genome Atlas database. Lists genes FerrDb GENCODE databases, respectively. The candidate prognostic signatures screened by Cox regression...

Almost 40% of patients with kidney renal clear cell carcinoma (KIRC) advanced cancers eventually develop to metastases, and their 5-year survival rates are approximately 10%. Aberrant DNA methylations significantly associated the development KIRC. The aim our present study was identify suitable ferroptosis- immune-related (FI) biomarkers correlated aberrant improve prognosis diagnosis KIRC.ChAMP DESeq2 in R (3.6.2) were used screen differentially expressed methylation probes genes,...

Cervical cancer is the fourth most common cancer. The 5-year survival rate for metastatic cervical less than 10%. time of patients with recurrent approximately 13-17 months. Cuproptosis a novel type cell death related to mitochondrial respiration. Accumulative studies showed that long non-coding RNAs (lncRNAs) regulated progression. Compressive bioinformatic analysis nine cuproptosis-related lncRNAs (CRLs), including C002128.2, AC002563.1, AC009237.14, AC048337.1, AC145423.1, AL117336.1,...

Abstract Background Kidney renal clear cell carcinoma (KIRC) is the most common type of kidney which has worst overall survival rate. Almost 30% patients with localized cancers eventually develop to metastases despite early surgical treatment carried out. MicroRNAs (miRNAs) play a critical role in human cancer initiation, progression, and prognosis. The aim our study was identify potential prognosis biomarkers predict KIRC. Methods All data were downloaded from an open access database Cancer...

Background To know the expression of Mesenchymal–Epithelial Transition factor (MET) and Fatty Acid Synthase (FASN) in Triple Negative Breast Cancer (TNBC) patients, as well its relationship with clinical pathological characteristic prognosis. Methods we used immunohistochemistry staining to detect MET FASN for those 218 TNBC analyze their Results 130 65 out patients were positive cancer adjacent tissues respectively. 142 30 Positive significantly correlated lymph node metastasis, TNM, Stage....

Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) are among the most common malignancies of female genital tract. Ferroptosis immunity regulate each other play important roles in progression CESC. The present study aimed to screen ferroptosis- immune-related differentially expressed genes (FI-DEGs) identify suitable prognostic signatures for patients with We downloaded RNAseq count data corresponding clinical information CESC from Cancer Genome Atlas database; obtained...

Background: Ferroptosis and immunity are novel treatments that target several cancers, including kidney renal clear cell carcinoma (KIRC). Long noncoding RNAs (lncRNAs) an important class of gene expression regulators play fundamental roles in the regulation ferroptosis immunity. We aimed to identify ferroptosis- immune-related lncRNAs as biomarkers patients with KIRC. Methods: Corresponding data for each patient KIRC were obtained from The Cancer Genome Atlas (TCGA) database. Univariate...

Colorectal cancer (CRC) is one of the most common cancers. Almost 1/3 CRC are rectal cancer, and 95% cancers adenocarcinoma (READ). Increasing evidences indicated that long noncoding RNAs (lncRNAs) have important role in genesis development The purpose our present study was to identify differential expression lncRNAs which potentially related with immune cells infiltration establish a risk assessment model predict clinical outcome for READ patients. We obtained three immune-related (IR-DELs)...

Abstract Background Hemifacial macrosomia (HFM, OMIM 164210) is a complex and highly heterogeneous disease. FORKHEAD BOX I3 ( FOXI3 ) susceptibility gene for HFM, mice with loss of function Foxi3 did exhibit phenotype similar to craniofacial dysmorphism. However, the specific pathogenesis HFM caused by deficiency remains unclear till now. Method In this study, we first constructed −/− mouse model verify mice, then used RNAseq data differential expression analysis screen candidate pathogenic...

Colorectal cancer (CRC) is one of the most common cancers. Almost 80% CRC cases are colon adenocarcinomas (COADs). Several studies have indicated role immunotherapy in treatment various Our study aimed to identify immune-related long non-coding RNAs (lncRNAs) and use them construct a risk assessment model for evaluating COAD prognosis. Using differential expression, correlation, Cox regression analyses, we identified three differentially expressed lncRNAs (IR-DELs) used model. The area under...

Heterogeneity of breast cancer (BRCA) is significantly correlated with its prognosis. Target therapy for ferroptosis and immunity a new treatment option discovered in recent years. In the present study, we aimed to identify ferroptosis- immune-related long non-coding RNAs (lncRNAs) accurately predict prognosis diagnosis patients infiltrating duct lobular carcinoma by integrated analyses.The corresponding data analyses were obtained from The Cancer Genome Atlas (TCGA). Analyses univariate...

Breast cancer (BC) is one of the most common malignancies affecting women. Ferroptosis a novel treatment option. The present study aimed to identify suitable ferroptosis-related lncRNAs predict and diagnose BC. Differential expression Cox regression analyses were used screen prognostic biomarkers construct risk model. We identified four differentially expressed (FR-DELs) (LINC01152, AC004585.1, MAPT-IT1, AC026401.3), which independently correlated with overall survival BC patients. area...

Abstract Background Colorectal cancer (CRC) is the second most prevalent cancer, as it accounts for approximately 10% of all annually diagnosed cancers. Studies have indicated that DNA methylation involved in genesis. The purpose this study was to investigate relationships among methylation, gene expression and tumor-immune microenvironment CRC, finally, identify potential key genes related immune cell infiltration CRC. Methods In present study, we used ChAMP DESeq2 packages, correlation...

Objective . This study constructed a model for the early diagnosis of gastric cancer by comparing serum peptides profiles patients with advanced and healthy people. And that may be potential to applied efficacy evaluation recurrence monitoring in cancer. Methods Serums 30 people were matched age gender collected. The peptide spectrum was obtained MB‐WCX concentration MALDI‐TOF MS analysis. Based on analysis efficiency differential cancer, we first established based then carried out external...

Colorectal cancer (CRC) is the third most common in world, and of them are adenocarcinomas. CRC could be classified as colon adenocarcinoma (COAD) rectum (READ) according to original tumorigenesis position. Increasing evidences indicated that microRNAs (miRNAs) play an important role occurrence multiple tumors.In this study, we firstly downloaded miRNA (COAD, 8 controls vs. 455 tumors; READ, 3 161 tumors) mRNA 41 478 10 166 data from The Cancer Genome Atlas (TCGA) database then used DESeq2,...

Background: Astragalus membranaceus (AM) is a traditional Chinese medicine that has been clinically utilized as an adjunctive therapy for the treatment of myocardial ischemia and heart failure; however, its precise molecular mechanism action remains unknown. Objective: This study aims to investigate potential pharmacological effects AM in ischemic failure (IHF) using network pharmacology methods, docking technology, vitro experiments. Methods: The active components targets were obtained from...

Cuproptosis is a novel type of copper-induced cell death and considered as new therapeutic target for many cancers. Distant metastases occur in about 40% patients with advanced renal carcinoma (RCC), poor 5-year prognosis 10%. Through series comprehensive analyses, four differentially expressed cuproptosis-related lncRNAs (DECRLs) were identified candidate biomarkers RCC. The risk model constructed by using these DECRLs can better predict the RCC, which determined receiver operating...

Kidney cancer (KC) is one of the most challenging cancers due to its delayed diagnosis and high metastasis rate. The 5-year survival rate KC patients less than 11.2%. Therefore, identifying suitable biomarkers accurately predict outcomes important urgent.Corresponding data for were obtained from International Cancer Genome Consortium (ICGC) Atlas (TCGA) databases. Systems biology/bioinformatics/computational approaches used identify predicting outcome immune landscapes patients.We found two...

Almost 75% of renal cancers are clear cell carcinomas (KIRC). Accumulative evidence indicates that epigenetic dysregulations closely related to the development KIRC. Cancer immunotherapy is an effective treatment for cancers. The aim this study was identify immune-related differentially expressed genes (IR-DEGs) associated with aberrant methylations and construct a risk assessment model using these IR-DEGs predict prognosis Two (SLC11A1 TNFSF14) were identified by differential expression,...

Objective To observe the effects of water-soluble CO-releasing molecules(CORM-3) on reactive oxygen species(ROS)in myocardial cells after hypoxia/reoxygenation. Methods After hypoxia for 6h, H9c2 cellswere treated with CORM-3 in 10 μmol/L, 50 100 μmol/L and 200 respectively, then effect was evaluated by detecting changesof ROS. The content ROS determined cell 2 h, 4 6 h reoxygenation to evaluate its time. Results The groupswassignificantly decreased, better group. contentof...