A5020488342- Facial Rejuvenation and Surgery Techniques
- Reconstructive Surgery and Microvascular Techniques
- Reconstructive Facial Surgery Techniques
- Facial Trauma and Fracture Management
- Facial Nerve Paralysis Treatment and Research
- Ophthalmology and Eye Disorders
- Tracheal and airway disorders
- Lymphatic System and Diseases
- Nasal Surgery and Airway Studies
- Dermatologic Treatments and Research
- Traumatic Ocular and Foreign Body Injuries
- Esophageal and GI Pathology
- Electrospun Nanofibers in Biomedical Applications
- Botulinum Toxin and Related Neurological Disorders
- Cleft Lip and Palate Research
- Diagnosis and Treatment of Venous Diseases
- Ocular Disorders and Treatments
- Surgical Sutures and Adhesives
- Wound Healing and Treatments
- Sexual function and dysfunction studies
- Silk-based biomaterials and applications
- Sinusitis and nasal conditions
- Nerve injury and regeneration
- Osteoarthritis Treatment and Mechanisms
- Sexuality, Behavior, and Technology
Wakayama Medical University
2016-2025
Primary Source
2024
Kishiwada Tokushukai Hospital
2022
Kindai University
2007-2016
Kyoto University
2014
Kindai University Hospital
2005-2008
Northeast Ohio Medical University
2002-2005
Ohio University
2002
To determine the potential development in vivo of tissue-engineered auricular cartilage, chondrocytes from articular cartilage bovine forelimb joints were seeded on poly(L-lactic acid-ε-caprolactone) copolymer scaffolds molded into shape a human ear. Copolymer alone same studied for comparison. Chondrocyte-seeded constructs and each implanted dorsal skin flaps athymic mice up to 40 weeks. Retrieved specimens examined by histological molecular techniques. After 10 weeks implantation,...
Lymphedema is an intractable disease most commonly associated with lymph node dissection for cancer treatment and can lead to a decreased quality of life. Type 2 T helper (Th2) lymphocytes have been shown be important in the progression lymphedema. The activation IL-33 its receptor, suppression tumorigenicity (ST2) signaling pathway, induces differentiation Th2 cells, but involvement lymphedema remains unclear. In present study, we analyzed dynamics immune cell infiltration, including...
Bone regeneration methods using bone inductive cytokines show promise, however, due to early diffusion and absorption of single applications these cytokines, the effects are limited. In this study, such a system was applied, gelatin hydrogel as carrier slowly release (bone morphogenetic proteins) BMP-2 over relatively long period in vivo. By coupling slow-release with biodegradable copolymer, composite evaluated by grafting into defect sites canine orbital floor fracture model....
Even though many different procedures have been proposed to involutional entropion, there is no established criterion standard in terms of the choice operative method. Considering anatomical difference lower eyelid structure between Asians and whites, we evaluated effectiveness our surgical approach entropion exclusively for Japanese patients.Twenty-one patients complained discomfort around eye, they also suffered from foreign body sensation, ocular pain, epiphora, photophobia. All with were...
Background There are many modified variations of the original Hotz procedure for repair epiblepharon. No matter which is used, there must be some factors that may cause recurrence. One possible causes these unsatisfactory results can due to presence epicanthal folds (EFs) among oriental population. It important determine whether patients should repaired with simple epiblepharon or if it combined epicanthoplasty especially actively growing children. Methods All were between 4 and 7 years old...
Background: In conventional studies on the regeneration of auricle-shaped cartilage in autogenous models using large animals, there were problems with induction capacity and long-term retention geometric shape. this study, authors sought to improve outcome these regards: a nonwoven fabric polyglycolic acid was developed through nanotechnology, effect nanofiber diameter vitro cell-seeding efficiency vivo response after implantation an large-animal model evaluated. Methods: Canine chondrocytes...
Abstract The post-surgical fluid leakage from the tubular tissues is a critical symptom after gastrointestinal or urinary tract surgeries. Elucidating mechanism for such abnormalities vital in surgical and medical science. exposure of as peritonitis due to perforation has been reported induce severe inflammation surrounding tissue. However, there have no reports tissue responses by extravasation assessment injury complication processes therefore vital. current model mouse study aims...
Objective: This study aimed to retrospectively evaluate the efficacy and safety of laser treatment oral vascular lesions using multiple spot irradiation technique with a single-pulsed wave. Background data: In therapy for lesions, heat accumulation induced by excessive can cause adverse events postoperatively, including ulcer formation, resultant scarring, severe pain. To prevent side effects, we have applied pulsed technique, so-called "leopard technique" (LT) lesions. approach was...
Structured Abstract Authors – Landis WJ, Jacquet R, Hillyer J, Lowder E, Yanke A, Siperko L, Asamura S, Kusuhara H, Enjo M, Chubinskaya Potter K, Isogai N. Objectives To develop models of human phalanges and small joints by suturing different cell‐polymer constructs that are then implanted in athymic (nude) mice. Design Models consisted bovine periosteum, cartilage, and/or tendon cells seeded onto biodegradable polymer scaffolds either polyglycolic acid (PGA) or copolymers PGA poly‐L‐lactic...
Abstract Background Lymphedema is an intractable disease that can be caused by injury to lymphatic vessels, such as surgical treatments for cancer. It lead impaired joint mobility in the extremities and reduced quality of life. Chronic inflammation due infiltration various immune cells area lymphedema thought local fibrosis, but molecular pathogenesis remains unclear. Development effective therapies requires elucidation immunological mechanisms involved progression lymphedema. The complement...
Abstract Purpose The pathophysiology of penis extends to erectile dysfunction (ED) conditions including sexually transmitted diseases (STDs) and cancer. To date, there has been little research evaluating vascular drainage from the penis. We aimed evaluate penile blood flow in vivo analyze its possible relationship with lymphatic maker. Materials Methods established an system designed assess dynamic outflow corpus cavernosum (CC) by dye injection. characteristics CC, expression Lyve‐1, key...
Ischemic gastropathy remains as a persistent problem after left gastric artery (LGA) resection in distal pancreatectomy with celiac axis en-bloc (DP-CAR). The middle colic (MCA) was found to be useful vessel for compromised collateral flow. However, intraoperative gross evaluation of ischemia is technically difficult even reconstruction.We performed LGA reconstruction by MCA-LGA bypass LGA-resecting DP-CAR assisted indocyanine green fluorescence imaging (ICG) blood flow clinical trial...
Transient Receptor Potential (TRP) ion channels mediate the influx of cations into cells responding to chemical or physical stimuli. TRP vanilloid 1 (TRPV1) regulates cutaneous functions. Its function in wound healing, however, has not been clarified. The current study elucidated role TRPV1 healing dorsal circular excisional injury using Trpv1-null (KO) and wild type (WT) male/female C57BL/6 mice. Macroscopic observation showed that remaining lesion was significantly larger KO than WT at...
This study was undertaken to characterize the relative degrees of arterial and venous trauma after graded avulsion injuries. Rat femoral arteries veins were subjected reproducible injuries using forces between 60 220g. Thrombotic occlusion occurred at lower in than arteries. Histologic scanning electron microscopic analysis indicated increased endothelial disruption exposed elastic lamina with increasing force both vessels, but more prominently Intercellular adhesion molecule-1 (ICAM-1) mRNA...
Animal serum used for tissue engineering approaches has unacceptable risk contamination with infectious agents. In this study, a cytokine-rich autologous (CRAS) system was developed. Canine auricular chondrocytes were cultured in medium supplemented either fetal bovine (FBS) or canine serum, alone basic fibroblast growth factor (b-FGF). Cell proliferative capacity higher the CRAS cultures than those FBS, greater expression of aggrecan and type II collagen b-FGF-supplemented group. The seeded...
There are many different operations to correct involutional blepharoptosis (IB); however, the outcome of corrective surgery is rather unpredictable, regardless procedure employed. A reasonably predictable can be achieved with careful intraoperative evaluation condition, measuring margin reflex distance-1 (MRD-1) in supine position patients. With these prepositions, we collected data that indicated our approach achieve a outcome. This was prospective study 21 consecutive patients (8 men and...
Free tissue transfer is the preferred reconstruction option in most major head and neck reconstructions. The pectoralis muscle musculocutaneous (PMMC) flap commonly used salvage of necrotic free flaps first choice for patients who are not candidates flaps. lateral thoracic artery (LTA), which thought to contribute blood perfusion inferior mammary area, preserved a conventionally harvested PMMC flap. With regard supply, it has been suggested that LTA should be preserved, addition pectoral...
Tissue-engineered models of human phalanges have previously been fabricated from a combination bovine periosteum, cartilage, tendon, and biodegradable polyglycolic acid poly-L-lactic scaffolds. Resulting constructs implanted in athymic mice for more than 40 weeks developed new bone, tendon became vascularized, but cell types comprising the were unidentified. The origin cells middle phalanx 20 nude has studied by situ hybridization analyzing species-specific gene expression. Oligonucleotide...