A5068748742- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Cancer Treatment and Pharmacology
- Colorectal Cancer Treatments and Studies
- DNA and Nucleic Acid Chemistry
- HER2/EGFR in Cancer Research
- Eosinophilic Esophagitis
- Metal complexes synthesis and properties
- Glycosylation and Glycoproteins Research
- Ferrocene Chemistry and Applications
- Testicular diseases and treatments
- Child Nutrition and Feeding Issues
- Autophagy in Disease and Therapy
- Sarcoma Diagnosis and Treatment
- Immune Response and Inflammation
- Drug-Induced Hepatotoxicity and Protection
- Reproductive Physiology in Livestock
- Chemotherapy-induced cardiotoxicity and mitigation
- Cytomegalovirus and herpesvirus research
- Liver physiology and pathology
- Cancer Genomics and Diagnostics
- Proteoglycans and glycosaminoglycans research
- Barrier Structure and Function Studies
- Cancer Cells and Metastasis
Universidad de Murcia
1993-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2010
Hospital César Milstein
2010
National Cancer Center
2010
Montefiore Einstein Comprehensive Cancer Center
2010
Universitat de Miguel Hernández d'Elx
1999-2008
Hospital Virgen de la Salud
2006
Vrije Universiteit Amsterdam
1998
University of Amsterdam
1995
Hospital Universitario Virgen de la Arrixaca
1993
We sought to determine whether the combination of ixabepilone plus capecitabine improved overall survival (OS) compared with alone in patients metastatic breast cancer (MBC) previously treated anthracyclines and taxanes.A total 1,221 MBC anthracycline taxanes were randomly assigned (40 mg/m(2) intravenously on day 1) (2,000 orally days 1 through 14) or (2,500 same schedule) given every 21 days. The trial was powered detect a 20% reduction hazard ratio (HR) for death.There no significant...
Abstract The c‐ kit proto‐oncogene product and its ligand stem cell factor play an important role in haematopoiesis, spermatogenesis, melanogenesis. Using anti‐c‐ antiserum raised against a synthetic peptide, we studied the immunohistochemical expression of gene 60 germ tumours (GCTs) (53 testicular, 7 extragonadal), derived from primary GCTs 45 cases metastatic 15 cases. Twenty‐eight out 28 seminomas showed membranous staining majority cells. A similar pattern was seen intratubular...
Food protein-induced enterocolitis (FPIES) is an uncommon, non-IgE-mediated food allergy that usually debuts in infancy with profuse vomiting, lethargy, and pallor 2-4 h following ingestion of the offending food. Its immune mechanism not known. We aimed to describe clinical features outcome children fish-FPIES as well investigate on cellular response implicated.Prospective follow-up study FPIES by fish over a period between 2004 2013 was conducted. Measurement vitro both cytokine production...
Abstract Optimal activation of human T cells mediated by ligation CD3/T cell receptor (TcR) complex requires co‐stimulatory signals. These can be provided the adhesive interaction between molecules on and their counter‐receptors antigen‐presenting cells. Soluble ICAM‐3, anti‐ICAM‐3 anti‐CD3 mAb were utilized to address role ICAM‐3/LFA‐1 pathway in TcR/CD3‐dependent or ‐independent activation. Immunoaffinity‐purified ICAM‐3 co‐immobilized with suboptimal concentrations monoclonal antibody...
Background: The lack of knowledge the progression mechanisms glioblastoma (GB), most aggressive brain tumor, contributes to absence successful therapeutic strategies. Our team has recently demonstrated a crucial new role for chaperone-mediated autophagy (CMA) in pericytes (PC)-acquired immunosuppressive function, which prevents anti-tumor immune responses and facilitates GB progression. possible impact that GB-induced CMA PC on other functions might be useful future prognosis/treatment, not...
Abstract Kp43 is a cell surface molecule expressed by NK cells, gamma delta T lymphocytes, and small subset of CD56+ alpha beta cells. In the present study distribution function on cells described. The expression freshly isolated T-cell populations derived from fetal adult tissues was biased toward memory V 2+/V 2+ lymphocytes appeared to be up-regulated after activation. Several clones were different sources. Adult highest levels Kp43, 1 periphery moderate levels, whereas some thymus...
Abstract Engagement of major histocompatibility complex (MHC) class I molecules on immune cells, where they are usually highly expressed, induces signal transduction events unclear significance. We show here that antibody-mediated cross-linking MHC-I human natural killer (NK) cells inhibits their cytotoxic activity against tumor target cells. Inhibition by anti-MHC monoclonal antibody exhibits molecular specificity and is an isotype Fc-independent process. Physical hindrance specific...
Glioblastoma (GB) is one of the most aggressive and treatment-resistant cancers due to its complex tumor microenvironment (TME). We previously showed that GB progression dependent on aberrant induction chaperone-mediated autophagy (CMA) in pericytes (PCs), which promotes TME immunosuppression through PC secretome. The secretion extracellular matrix (ECM) proteins with anti-tumor (Lumican) pro-tumoral (Osteopontin, OPN) properties was shown be regulation GB-induced CMA PCs. As biomarkers are...
Malignancies found in children and adults with constitutional trisomy 8 mosaicism (CT8M) could be part the consequence of dysfunction trisomic immune cells. An adult patient exhibiting entire natural killer (NK) cell population has made possible characterization 8-positive NK The study showed normal cytotoxic activity but predominance an immunosenescent phenotype (CD56dimCD94/NKG2bright) characterized by a weak response to IL-2, increased upregulation CD95/Fas, impaired TNF-α production. As...
Abstract Congenital disorders of glycosylation (CDG) include 150 genetically and clinically heterogeneous diseases, showing significant glycoprotein hypoglycosylation that leads to pathological consequences in multiple organs systems whose underlying mechanisms are not yet understood. A few cellular animal models have been used study specific CDG characteristics, although they given limited information due the mutations tested still missing comprehensive molecular basic research. Here, we...