A5083204382- Reproductive tract infections research
- Extracellular vesicles in disease
- Syphilis Diagnosis and Treatment
- Bacterial Infections and Vaccines
- Sperm and Testicular Function
- Streptococcal Infections and Treatments
- Neonatal and Maternal Infections
- Reproductive System and Pregnancy
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Microbial infections and disease research
- Nanoplatforms for cancer theranostics
- Asthma and respiratory diseases
- Hip and Femur Fractures
- Antibiotic Resistance in Bacteria
- Contact Dermatitis and Allergies
- Circular RNAs in diseases
- Plant Pathogenic Bacteria Studies
- Antimicrobial Resistance in Staphylococcus
- Vibrio bacteria research studies
- Allergic Rhinitis and Sensitization
- Genomics and Phylogenetic Studies
- Nuclear Structure and Function
- Global Health Workforce Issues
- Enzyme Production and Characterization
The University of Queensland
2020-2024
Queensland Children’s Hospital
2024
Queensland University of Technology
2014-2023
Translational Research Institute
2014-2018
Abstract Identification of novel therapeutic targets is required for developing alternate strategies to treat infections caused by the extensively drug-resistant bacterial pathogen, Acinetobacter baumannii . As capsular polysaccharide (CPS) a prime virulence determinant evasion host immune defenses, understanding pathways synthesis and assembly this discrete cell-surface barrier important. In study, we assess cell-bound cell-free CPS material from A. AB5075 wildtype transposon library...
Mycoplasma genitalium infection is a sexually transmitted that has rapidly become resistant to mainstay treatments. While individualized treatment approaches have been recommended and adopted for macrolides, therapy fluoroquinolones not yet explored, due lack of commercial molecular assays confidence in specific mutations associated with resistance. In another recent study, we defined clear role diagnostic utility focusing on the absence resistance inform microbial cure fluoroquinolone...
Whole genome sequences of two Acinetobacter baumannii clinical isolates, 48-1789 and MAR24, revealed that they carry the KL106 KL112 capsular polysaccharide (CPS) biosynthesis gene clusters, respectively, at chromosomal K locus. The clusters are related to previously described KL11 KL83 sharing genes for synthesis l-rhamnose (l-Rhap) 6-deoxy-l-talose (l-6dTalp). CPS material isolated from MAR24 was studied by sugar analysis Smith degradation along with one- two-dimensional 1H 13C NMR...
The gradual replacement of the Streptococcus pyogenes M1global genotype by a newly emergent M1UK variant is global public health threat warranting increased surveillance. differs from progenitor 27 single-nucleotide polymorphisms and characterized speA superantigen expression in vitro. An allele-specific real-time polymerase chain reaction assay was developed for rapid detection strains. used combination with whole genome sequencing to determine emm (sub)type distribution 51 invasive (n = 9)...
Mycoplasma genitalium is a sexually-transmitted organism that causes non-gonococcal urethritis in men and pelvic inflammatory disease women.In Australia, there concern over the emergence spread of antimicrobial resistance (AMR) M. while high levels AMR have been reported who sex with (1, 2), it not clear if specific to particular strain, nor any information on diversity strains Australia.We successfully genotyped 89/111 genitalium-positive samples collected from 2013-2019 (majority...
Abstract Problem Group B Streptococcus (GBS) is a common colonizer of the female genital tract at time pregnancy and has been associated with severe neonatal infections. Despite trials for GBS vaccines already being underway, factors influencing vaginal colonization clearance are currently poorly understood. Method study Within this study, we investigated host immune responses to infections in mice that affect clearance. Cervicovaginal swabs were used measure persistence, cytokine measured...
Chlamydia is the most commonly reported sexually transmitted bacterial infection, with 127 million notifications worldwide each year. Both males and females are susceptible to pathological impacts on fertility that infections can induce. However, male chlamydial infections, particularly within upper reproductive tract, including testis, not well characterized. In this study, using mouse testicular cell lines, we examined impact of infection lineage transcriptomes potential mechanisms for...
With ~78 million cases yearly, the sexually transmitted bacterium Neisseria gonorrhoeae is an urgent threat to global public health due continued emergence of antimicrobial resistance. In male reproductive tract, untreated infections may cause permanent damage, poor sperm quality, and subsequently subfertility. Currently, few animal models exist for N. infection, which has strict human tropism, available have limited translatability disease. The absence appropriate inhibits development vital...