Abstract Background Hyaluronic acid (HA) is a widely used active cosmetic ingredient. Its multiple skin care benefits are modulated by its molecular weight. Low weight (LMW) HA can penetrate the skin, but high (HMW) remains at surface. Here, we assessed how vectorization of HMW with bentonite clay—achieved an innovative technology—enhances and hydrating properties. Materials Methods The two forms were applied to explants; their penetration smoothing effects monitored Raman spectroscopy...

Abstract Background Conspicuous facial pores are benign but represent a cosmetic concern for men and women. Recent works described dermal epidermal impairments as clinical causes of enlarged pores. Morphological modifications skin at the site were associated with collagen density loss, possible alteration extracellular matrix abnormal differentiation keratinocytes. Aims A composition containing mannose‐6‐phosphate (Active Complex) was designed to address these different aspects pore...

(1) Background: Preclinical studies report that the ethanolic fraction from Mangifera indica leaves is a potential anti-acne agent. Nevertheless, biological activity of has scarcely been investigated, and additional data are needed, especially in clinical setting, for establishing actual effectiveness extract as an active component therapy. (2) Methods: The evaluation was carried out through different experimental phases, which comprised silico, vitro, ex vivo evaluations. (3) Results: In...

Digital stress is a newly identified cosmetic that mainly characterized by blue light exposure. The effects of this have become increasingly important with the emergence personal digital devices, and its deleterious on body are now well-known. Blue has been observed to cause perturbation natural melatonin cycle skin damage similar from UVA exposure, thus leading premature aging. “A melatonin-like ingredient” was discovered in extract Gardenia jasminoides, which acts as filter against...

Abstract Background Several studies evidenced significant increase of cortisol is the consequence UV or emotional stress and leads to various deleterious effects in skin. Aim The well‐aging, a new concept lifestyle, procures an alternative anti‐aging strategy. We demonstrated that Tephrosia purpurea extract able stimulate well‐being hormones while reducing release. Furthermore, we hypothesized could positively influence global skin homeostasis. Method evaluated impact on cortisol,...

Background: Skin is exposed to ultraviolet radiation (UV) and air pollution, recent works have demonstrated that these factors additive effects in the disturbance of skin homeostasis. Nuclear-factor-erythroid-2-related factor 2 (Nrf2) aryl hydrocarbon receptor (AHR) appear be appropriate targets management combined environmental stressors. The protective silymarin (SM), an antioxidant anti-inflammatory complex flavonoids, were evaluated. Methods: Reactive oxygen species (ROS) interleukin...

Summary Background Healthy skin is a delicate balance between renewal and microbiota homeostasis, its imbalance promotes premature aging dermatological disorders. Skin stem cells are key actors in this process but their sensitivity to external stressors such as UV reduces the power. The has been recently described active healthy skin, could trigger some Aims We hypothesized that reactivation of maintenance be disruptive strategy for younger healthier skin. thus developed new plant extract...

One of the most visible signs hair ageing is greying hair, also known as canities. This disorder mainly caused by oxidative stress. In preliminary work, we designed various models mimicking impact stress on pigmentation, showing an accumulation reactive oxygen species (ROS) production and a decrease in presence melanocytes melanoblasts, resulting pigmentation. A proteomic study skin scalp explants was performed to identify dysregulated biological pathways related We developed smart active...

Skin lipids are essential in every compartment of the skin where they play a key role various biological functions. Interestingly, their is central maintenance hydration which related to barrier function and structure through adipose tissue. It well described today that affected by ageing giving sagging, wrinkles dryness. Thereby, developing cosmetic actives able reactivate would be an efficient ant-ageing strategy. Due strong commitment our scientists innovate responsibly create value,...

Intrinsic aging promotes wrinkles formation by an imbalance between matrix synthesis/degradation in favor of degradation. This is accelerated the exposome leading to overproduction protease and fewer remodeling.Protecting integrity extracellular appears as most efficient anti-aging solution. We developed a grafted HA specifically designed get property due specific molecular weight acetylation degree.A transcriptomic analysis was performed on fibroblasts, followed measurement MMP secretion...

Microbiome supplementation initially targeted the gut microbiota but has since been extended to skin. A new category, psychobiotics, defined beneficial compounds with a positive action on microbiota, providing benefits host’s mental health. Pogostemon cablin leaf extract, proven alleviate scalp dryness, was clinically evaluated volunteers presenting dry flakes. metagenomics study and sebum production analysis were performed, coupled flakes scoring. The of extract emotions assessed through...

Dark spots, brown or hyperpigmented spots (HPS) are oval irregular areas of skin. Their emergence is associated with dysregulation the immune system, and may also be caused by a deficiency in stromal cell-derived factor-1, leading to perturbed melanogenesis accumulation melanosomes within neighboring keratinocytes. The skin microbiota (living microorganisms present on surface skin) known play essential roles maintaining homeostasis regulating system. Here, we investigated whether could role...

Active ingredients are often assessed based on physiological measurements, but innovative technologies to measure skin sensations can provide a holistic volunteer assessment of the use an ingredient. In this paper, hydrating benefits cationic hyaluronic acid (HA) were evaluated alongside clinical biometrics and cognitive measurements determine how biological correlated with volunteers' feelings perceptions hydration. The results demonstrated that HA provides at level due its film-forming...

Vitamin A, or retinol, is one of the most effective antiaging molecules, but it presents issues with photo-sensitivity and irritation. Alternatives are emerging, have so far been less effective.

The COVID-19 pandemic brought about a new normal, necessitating the use of personal protective equipment (PPE) like face shields, surgical masks, gloves, and goggles. However, prolonged mask-wearing introduced skin-related issues due to changes in skin's microenvironment, including increased humidity temperature, as well pressure on skin. These factors led skin deformation, vascular issues, edema, inflammation, resulting discomfort cosmetic concerns. Clinical reports quickly highlighted...

Vitamin A, or retinol, is one of the most effective anti-ageing molecules, but it presents issues with photo-sensitivity and irritation. Retinol-like alternatives are emerging, have so far been less effective. Here, we present a Silibum marianum extract (SME) as retinol-like ingredient providing both safety efficacy. SME was compared to reference compound, main alternative, bakuchiol. In ex vivo tests, skin explants from 58-year-old donor were treated pure retinol (0.1%), bakuchiol (0.2%)...

(1) Background: Ultraviolet radiation takes part in photoaging and pigmentation disorders on skin. Epigallocatechin gallate (EGCG) is a well-known brightening photoprotective compound but it faces limitations terms of stability solubility. (2) Methods: A more stable water-soluble glucoside called EGCG-G1 was obtained by enzymatic glucosylation EGCG. In vitro ex vivo experiments evaluated skin penetration, antioxidant activity, antimelanogenic properties compared to This gene expression study...

Background: Skin is exposed to ultraviolet radiation (UV) and air pollution recent works demonstrated these factors have additive effects in the disturbance of skin homeostasis. Nuclear factor erythroid 2-related 2 (Nrf2) aryl hydrocarbon receptor (AHR) appears appropriate targets management combined environmental stressors. The protective Silymarin (SM), an antioxidant anti-inflammatory complex flavonoids, were evaluated. Methods: Reactive oxygen species (ROS) interleukin 1-alpha (IL-1a)...

Our understanding of the interplay between skin microbiota and skin’s health status is growing. Consequently, cosmetics industry increasingly concerned with ensuring that beauty products do not adversely affect this health. Prior to implementing demanding sequencing-based analyses microbiota, an agile approach needed provide a first estimate short-term impact cosmetic ingredients on viability microbiota. A standardized methodology, including topical applications, swabbing, bacterial...