A5018847919- Skin Protection and Aging
- melanin and skin pigmentation
- Bee Products Chemical Analysis
- Chronic Myeloid Leukemia Treatments
- Wound Healing and Treatments
- Dermatology and Skin Diseases
- Dermatologic Treatments and Research
- Medicinal Plants and Neuroprotection
- Chronic Lymphocytic Leukemia Research
- Advancements in Transdermal Drug Delivery
- Circadian rhythm and melatonin
- Historical and Scientific Studies
- Fungal Plant Pathogen Control
- Pluripotent Stem Cells Research
- Cellular Mechanics and Interactions
- Spectroscopy Techniques in Biomedical and Chemical Research
- Acute Lymphoblastic Leukemia research
- Acne and Rosacea Treatments and Effects
- TGF-β signaling in diseases
- Hair Growth and Disorders
- Nasal Surgery and Airway Studies
- Philosophical and Theoretical Analysis
- Silk-based biomaterials and applications
- Whipple's Disease and Interleukins
- COVID-19 and healthcare impacts
Givaudan (France)
2018-2024
Matrice Extracellulaire et Dynamique Cellulaire MEDyC
2021
Centre National de la Recherche Scientifique
2018-2021
Université de Reims Champagne-Ardenne
2018-2021
Hôpital Saint-Louis
2020
Inserm
2010-2020
Assistance Publique – Hôpitaux de Paris
2015-2020
Université Paris Cité
2020
Pitié-Salpêtrière Hospital
2015
Sorbonne Université
2015
Abstract Background Hyaluronic acid (HA) is a widely used active cosmetic ingredient. Its multiple skin care benefits are modulated by its molecular weight. Low weight (LMW) HA can penetrate the skin, but high (HMW) remains at surface. Here, we assessed how vectorization of HMW with bentonite clay—achieved an innovative technology—enhances and hydrating properties. Materials Methods The two forms were applied to explants; their penetration smoothing effects monitored Raman spectroscopy...
Abstract Background Conspicuous facial pores are benign but represent a cosmetic concern for men and women. Recent works described dermal epidermal impairments as clinical causes of enlarged pores. Morphological modifications skin at the site were associated with collagen density loss, possible alteration extracellular matrix abnormal differentiation keratinocytes. Aims A composition containing mannose‐6‐phosphate (Active Complex) was designed to address these different aspects pore...
Abstract Background Monitoring the transcutaneous permeation of exogenous molecules using conventional techniques generally requires long pre‐analytical preparation or labelling samples. However, Raman spectroscopy is a label‐free and non‐destructive method which provides spatial distribution tracked actives in skin. The aim our study was to prove interest imaging coupled with multivariate curve resolution alternating least square (MCR‐ALS) analysis monitoring retinol penetration into frozen...
LRP-1 is a multifunctional scavenger receptor belonging to the LDLR family. Due its capacity control pericellular levels of various growth factors and proteases, plays crucial role in membrane proteome dynamics, which appears decisive for tumor progression.LRP-1 involvement TNBC model was assessed using an RNA interference strategy MDA-MB-231 cells. In vivo, tumorigenic angiogenic effects LRP-1-repressed cells were evaluated orthotopic xenograft two assays (Matrigel® plugs, CAM). DCE-MRI,...
Recent technological advances in cell reprogramming by generation of induced pluripotent stem cells (iPSC) offer major perspectives disease modelling and future hopes for providing novel sources regenerative medicine. However, research on iPSC still requires refining the criteria pluripotency stage these exploration their equivalent functionality to human embryonic (ESC). We report here use infrared microspectroscopy follow spectral modification somatic during process. show that adopt a...
Abstract Background Several studies evidenced significant increase of cortisol is the consequence UV or emotional stress and leads to various deleterious effects in skin. Aim The well‐aging, a new concept lifestyle, procures an alternative anti‐aging strategy. We demonstrated that Tephrosia purpurea extract able stimulate well‐being hormones while reducing release. Furthermore, we hypothesized could positively influence global skin homeostasis. Method evaluated impact on cortisol,...
Background: Hyaluronic acid (HA) is well known in the cosmetic industry for its hydrating properties linked to interaction with keratin stratum corneum. Hair also mainly composed of keratin, but no evidence penetration and HA hair had yet been established. Herein, we examined, appropriate methods, this interaction. Methods: Confocal Raman Spectroscopy was used track fibers. Human UV-irradiated, or not, before washing a number different shampoo formulations. Low-molecular weight hyaluronic...
Stretch marks are far from exclusively appearing on pregnant women and appear whenever the body experiences rapid growth. Collagen fibres altered in dermis, which is associated with a loss of orientation, elastic network disrupted, leading to fibrotic organisation. This results epidermal tearing that produces skin lesions. Centella asiatica (CAST) well-known medicinal plant rich active triterpenic molecules traditionally used treat wounds help repair. The aim this study was evaluate CAST...
Abstract A method was developed to characterize the adhesion properties of single cells by using protein‐functionalized atomic force microscopy (AFM) probes. The quantification spectroscopy mean detachment between and a gelatin‐functionalized colloidal tip reveals differences in cell that are not within reach traditional bulk technique, washing assay. In this latter method, experiments yield semiquantitative average large population cells. They also limited stringent conditions cannot...
Summary Background Healthy skin is a delicate balance between renewal and microbiota homeostasis, its imbalance promotes premature aging dermatological disorders. Skin stem cells are key actors in this process but their sensitivity to external stressors such as UV reduces the power. The has been recently described active healthy skin, could trigger some Aims We hypothesized that reactivation of maintenance be disruptive strategy for younger healthier skin. thus developed new plant extract...
While our body ages, skin cells progressively lose their pluripotency and proliferative capacities, as well remodeling driver role, among other activities. This loss of capacities leads to visible aging signs such wrinkles, under-eye bags or even spots. We studied if the stimulation cell proliferation by a natural molecule could be an innovative anti-ageing strategy for rejuvenation.The activity sericoside, compound extracted from bark Terminalia sericea roots, was evaluated at concentration...
Intrinsic aging promotes wrinkles formation by an imbalance between matrix synthesis/degradation in favor of degradation. This is accelerated the exposome leading to overproduction protease and fewer remodeling.Protecting integrity extracellular appears as most efficient anti-aging solution. We developed a grafted HA specifically designed get property due specific molecular weight acetylation degree.A transcriptomic analysis was performed on fibroblasts, followed measurement MMP secretion...
Microbiome supplementation initially targeted the gut microbiota but has since been extended to skin. A new category, psychobiotics, defined beneficial compounds with a positive action on microbiota, providing benefits host’s mental health. Pogostemon cablin leaf extract, proven alleviate scalp dryness, was clinically evaluated volunteers presenting dry flakes. metagenomics study and sebum production analysis were performed, coupled flakes scoring. The of extract emotions assessed through...
Active ingredients are often assessed based on physiological measurements, but innovative technologies to measure skin sensations can provide a holistic volunteer assessment of the use an ingredient. In this paper, hydrating benefits cationic hyaluronic acid (HA) were evaluated alongside clinical biometrics and cognitive measurements determine how biological correlated with volunteers' feelings perceptions hydration. The results demonstrated that HA provides at level due its film-forming...
Stretch marks are far from being exclusively appearing on pregnant women and appear whenever the body experience a rapid growth. Into dermis, collagen fibres altered associated with loss of orientation elastic network is disrupted leading to fibrotic organisation. This results epidermal tearing which produce skin lesions. Centella asiatica well-known medicinal plants rich in triterpenic actives molecules traditionally used treat wounds help repair. The aim this study was evaluate extract as...