A5070723176- Neurobiology and Insect Physiology Research
- Insect and Arachnid Ecology and Behavior
- Photoreceptor and optogenetics research
- Physiological and biochemical adaptations
- Circadian rhythm and melatonin
- Neural dynamics and brain function
- Insect Utilization and Effects
- Advanced Image and Video Retrieval Techniques
- Robotics and Sensor-Based Localization
- Olfactory and Sensory Function Studies
- Animal Behavior and Reproduction
- Neuroscience and Neural Engineering
- Micro and Nano Robotics
- Tactile and Sensory Interactions
- Biochemical Analysis and Sensing Techniques
- Insect Pheromone Research and Control
- Molecular Communication and Nanonetworks
- Gene Regulatory Network Analysis
- Diffusion and Search Dynamics
- Plant and Biological Electrophysiology Studies
- Evolution and Genetic Dynamics
- Video Surveillance and Tracking Methods
- Microfluidic and Bio-sensing Technologies
Harvard University
2014-2022
Center for Systems Biology
2015-2021
Quantitative BioSciences
2020-2021
National University of Engineering
2020
Harvard University Press
2020
SIB Swiss Institute of Bioinformatics
2016
University of Bern
2016
University of Lausanne
2016
Center for Pain and the Brain
2015-2016
Yale University
2014
The sense of smell enables animals to react long-distance cues according learned and innate valences. Here, we have mapped with electron microscopy the complete wiring diagram Drosophila larval antennal lobe, an olfactory neuropil similar vertebrate bulb. We found a canonical circuit uniglomerular projection neurons (uPNs) relaying gain-controlled ORN activity mushroom body lateral horn. A second, parallel multiglomerular (mPNs) hierarchically connected local (LNs) selectively integrates...
Significance A previously unidentified set of thermosensory neurons embedded in the olfactory organ Drosophila larva is shown to be required drive animal up temperature gradients toward preferred environments. Optogenetics and optical neurophysiology reveal efficient sensory encoding both favorable (warming) unfavorable (cooling) stimuli for distinct components thermotactic strategy by this one neurons. Cooling-evoked activation used curtail forward movements directions; warming-evoked...
Bacterial chemotaxis systems are as diverse the environments that bacteria inhabit, but how much environmental variation can cells tolerate with a single system? Diversification of system could serve an alternative, or even evolutionary stepping-stone, to switching between multiple systems. We hypothesized mutations in gene regulation lead heritable control chemotactic diversity. By simulating foraging and colonization E. coli using single-cell model, we found different selected for...
Neural circuits for behavior transform sensory inputs into motor outputs in patterns with strategic value. Determining how neurons along a sensorimotor circuit contribute to this transformation is central understanding behavior. To do this, quantitative framework describe behavioral dynamics needed. In study, we built high-throughput optogenetic system Drosophila larva quantify the transformations underlying navigational We express CsChrimson, red-shifted variant of channelrhodopsin,...
The first olfactory processing center in the larval Drosophila brain uses information about feeding state to shape behavior.
Inputs to signaling pathways can have complex statistics that depend on the environment and behavioral response previous stimuli. Such feedback is particularly important in navigation. Successful navigation relies proper coupling between sensors, which gather information during motion, actuators, control behavior. Because reorientation conditions future inputs, place sensors actuators an operational regime different from resting state. How then organisms maintain transfer through pathway...
Accurate perception of taste information is crucial for animal survival. In adult Drosophila, gustatory receptor neurons (GRNs) perceive chemical stimuli one specific modality associated with a stereotyped behavioural response, such as aversion or attraction. We show that GRNs Drosophila larvae employ surprisingly different mode coding. Using novel method calcium imaging in the larval system, we identify multimodal GRN responds to chemicals modalities opposing valence, sweet sucrose and...
State-of-the-art algorithms for visual place recognition, and related navigation systems, can be broadly split into two categories: computer-science-oriented models including deep learning or image retrieval-based techniques with minimal biological plausibility, neuroscience-oriented dynamical networks that model temporal properties underlying spatial in the brain. In this letter, we propose a new compact high-performing recognition bridges divide first time. Our approach comprises key...
Body temperature homeostasis is essential and reliant upon the integration of outputs from multiple classes cooling- warming-responsive cells. The computations that integrate these are not understood. Here, we discover a set warming cells (WCs) show WCs combine with previously described cooling (CCs) in cross-inhibition computation to drive thermal larval Drosophila CCs detect changes using overlapping combinations ionotropic receptors: Ir68a, Ir93a, Ir25a for Ir21a, CCs. mediate avoidance...
Abstract The sense of smell enables animals to react long-distance cues according learned and innate valences. Here, we have mapped with electron microscopy the complete wiring diagram Drosophila larval antennal lobe, an olfactory neuropil similar vertebrate bulb. We found a canonical circuit uniglomerular projection neurons (uPNs) relaying gain-controlled ORN activity mushroom body lateral horn. A second, parallel multiglomerular (mPNs) hierarchically connected local (LNs) selectively...
Animals exhibit different behavioral responses to the same sensory cue depending on their state at a given moment in time. How and where brain are inputs combined with internal information select an appropriate behavior? Here we investigate how food deprivation affects olfactory behavior Drosophila larvae. We find that certain odors reliably repel well-fed animals but attract food-deprived animals. show feeding flexibly alters neural processing first center, antennal lobe. Food...
Neural circuits for behavior transform sensory inputs into motor outputs in patterns with strategic value. Determining how neurons along a sensorimotor circuit contribute to this transformation is central understanding behavior. To do this, quantitative framework describe behavioral dynamics needed. Here, we built high-throughput optogenetic system Drosophila larva quantify the transformations underlying navigational We express CsChrimson, red-shifted variant of Channelrhodopsin, specific...
Body temperature homeostasis is an essential function that relies upon the integration of outputs from multiple classes cooling- and warming-responsive cells. The computations integrate these diverse to control body are not understood. Here we discover a new set Warming Cells (WCs), show WCs previously described Cooling (CCs 1 ) combined in cross-inhibition computation drive thermal larval Drosophila . We find CCs opponent sensors operate synchrony above, below, near homeostatic set-point,...
Abstract Animals use their olfactory systems to avoid predators, forage for food, and identify mates. Olfactory detect distinguish odors by responding the concentration, temporal dynamics, identities of odorant molecules. Studying neural processing carried in air has been difficult because inherent challenge precisely controlling odorized airflows over time. Odorized interact with surfaces other currents, leading a complex transformation from airflow that is desired stimulus delivered. Here,...