A5073099820- Malaria Research and Control
- Plant biochemistry and biosynthesis
- Monoclonal and Polyclonal Antibodies Research
- Cytomegalovirus and herpesvirus research
- Hepatitis C virus research
- Pharmacological Effects of Natural Compounds
- Toxoplasma gondii Research Studies
- Vibrio bacteria research studies
- Research on Leishmaniasis Studies
- Parasitic Infections and Diagnostics
- Hepatitis B Virus Studies
- Trypanosoma species research and implications
- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
Barcelona Institute for Global Health
2022-2024
Universitat de Barcelona
2022-2024
Helmholtz Centre for Infection Research
2020
Center for Experimental and Clinical Infection Research
2020
A proposed treatment for malaria is a combination of fosmidomycin and clindamycin. Both compounds inhibit the methylerythritol 4-phosphate (MEP) pathway, parasitic source farnesyl geranylgeranyl pyrophosphate (FPP GGPP, respectively). FPP GGPP are crucial biosynthesis several essential metabolites such as ubiquinone dolichol, well protein prenylation. Dietary prenols, farnesol (FOH) geranylgeraniol (GGOH), can rescue parasites from MEP inhibitors, suggesting existence missing pathway prenol...
CD81 plays a central role in variety of physiological and pathological processes. Recent structural analysis indicates that it contains an intramembrane cholesterol-binding pocket interaction with cholesterol may regulate conformational switch the large extracellular domain CD81. Therefore, possesses potential cholesterol-sensing mechanism; however, its relevance for protein function is thus far unknown. In this study we investigate sensing context activity as receptor hepatitis C virus...
The emergence of resistance to first-line antimalarials, including artemisinin, the last effective malaria therapy in some regions, stresses urgent need develop new treatments against this disease. identification and validation metabolic pathways that could be targeted for drug development may strongly contribute accelerate process. In study, we use fully characterized specific inhibitors targeting glycan biosynthetic as research tools analyze their effects on growth parasite Plasmodium...
The cell surface of Toxoplasma gondii is rich in glycoconjugates which hold diverse and vital functions the lytic cycle this obligate intracellular parasite. Additionally, cyst wall bradyzoites, that shields persistent form responsible for chronic infection from immune system, heavily glycosylated. Formation relies on activated sugar nucleotides, such as uridine diphosphate N -acetylglucosamine (UDP-GlcNAc). glucosamine-phosphate- -acetyltransferase (GNA1) generates...
Abstract An estimated number of 71 million people are living with chronic hepatitis C virus (HCV) infection worldwide and 400,000 annual deaths related to the infection. HCV entry into hepatocytes is complex involves several host factors. The tetraspanin human CD81 (hCD81) one four essential factors composed large extracellular loop, small transmembrane domains, intracellular loop two tails. interacts E2 glycoprotein HCV. Regions outside (backbone) hCD81 have a critical role in post-binding...
The cell surface of Toxoplasma gondii is rich in glycoconjugates which hold diverse and vital functions the lytic cycle this obligate intracellular parasite. Additionally, cyst wall bradyzoites, that shields persistent form responsible for chronic infection from immune system, heavily glycosylated. Formation relies on activated sugar nucleotides, such as uridine diphosphate N-acetylglucosamine (UDP-GlcNAc). Glucosamine-phosphate-N-acetyltransferase (GNA1) generates...
UDP-N-acetylglucosamine (UDP-GlcNAc) is a crucial sugar nucleotide for glycan synthesis in eukaryotes. In the malaria parasite Plasmodium falciparum, UDP-GlcNAc synthesized via hexosamine biosynthetic pathway (HBP) and essential glycosylphosphatidylinositol (GPI) anchor production, most prominent form of protein glycosylation parasite. this study, we explore conditional knockout glucosamine-6-phosphate N-acetyltransferase (PfGNA1), key HBP enzyme. PfGNA1 depletion led to significant...
Abstract A promising treatment for malaria is a combination of fosmidomycin and clindamycin. Both compounds inhibit the methylerythritol 4-phosphate (MEP) pathway, parasitic source farnesyl geranylgeranyl pyrophosphate (FPP GGPP, respectively). FPP GGPP are crucial biosynthesis several essential metabolites such as ubiquinone dolichol, well protein prenylation. Dietary prenols, farnesol (FOH) geranylgeraniol (GGOH), can rescue parasites from MEP inhibitors, suggesting existence missing...