A5072783052- Folate and B Vitamins Research
- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- Neuroscience and Neuropharmacology Research
- Retinal Development and Disorders
- Neuroscience and Neural Engineering
- Cannabis and Cannabinoid Research
- Photosynthetic Processes and Mechanisms
- Blood Coagulation and Thrombosis Mechanisms
- Polyamine Metabolism and Applications
- Esophageal and GI Pathology
- ATP Synthase and ATPases Research
- Urbanism, Landscape, and Tourism Studies
- Histone Deacetylase Inhibitors Research
- Cancer, Lipids, and Metabolism
- Photoreceptor and optogenetics research
- RNA modifications and cancer
- Amino Acid Enzymes and Metabolism
- Cell death mechanisms and regulation
Hospital Virgen del Puerto
2013
Universidad de Extremadura
2007-2013
Centro de Investigaciones Biológicas Margarita Salas
2013
Escuela Nacional de Sanidad
2013
Instituto de Salud Carlos III
2013
Consejo Superior de Investigaciones Científicas
2007
Universidad de Málaga
2001-2003
Abstract Programmed cell death is a genuine developmental process of the nervous system, affecting not only projecting neurons but also proliferative neuroepithelial cells and young neuroblasts. The embryonic chick retina has been employed to correlate in vivo vitro studies on regulation. We characterize here role two major signaling pathways, PI3K‐Akt MEK‐ERK, controlled retinal organotypic cultures from day 5 (E5) E9, when preferentially affects proliferating ganglion neurons,...
Orchestrated proliferation, differentiation, and cell death contribute to the generation of complex cytoarchitecture central nervous system, including that neuroretina. However, few studies have comprehensively compared spatiotemporal patterns these 3 processes, or their relative magnitudes. We performed a parallel study in embryonic chick mouse retinas, focusing on period during which first neurons, retinal ganglion cells (RGCs), are generated. The combination vivo BrdU incorporation,...
The effects of histamine on polyamine uptake and metabolism was studied in a mouse mast cell line (C57.1), as model which both biogenic amines are important for maintaining function viability. Results obtained after incubations with exogenous indicated that prevents accumulation by affecting uptake. A plasma membrane transport system polyamines has been also cells. It seems to be Na(+)-dependent high affinity spermine spermidine lower putrescine agmatine. Polyamine reduced cells treated...