A5050245408- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Psoriasis: Treatment and Pathogenesis
- Adipokines, Inflammation, and Metabolic Diseases
- Inflammatory Bowel Disease
- Eosinophilic Esophagitis
- Pregnancy and Medication Impact
- Autoimmune Neurological Disorders and Treatments
- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Tryptophan and brain disorders
- Lipoproteins and Cardiovascular Health
- Drug Transport and Resistance Mechanisms
- Peripheral Neuropathies and Disorders
- Lipid metabolism and disorders
- Retinoids in leukemia and cellular processes
- Bone and Joint Diseases
- Liver Disease Diagnosis and Treatment
- Estrogen and related hormone effects
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Collaborative Teaching and Inclusion
- Experimental Behavioral Economics Studies
- Accounting and Organizational Management
- Adrenal Hormones and Disorders
- Fibroblast Growth Factor Research
Duke University
2025
UCB Pharma (United States)
2021-2024
Medical College of Wisconsin
2024
Versiti Blood Center of Wisconsin
2024
University of Pennsylvania
2020-2022
UCB Pharma (Belgium)
2022
University of California, San Francisco
2022
The University of Queensland
2022
Oregon Health & Science University
2022
Bielefeld University
2022
Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear that vital regulator of adipogenesis, insulin sensitivity, and lipid metabolism. Activation PPARγ by antidiabetic thiazolidinediones (TZD) reverses resistance but also leads to weight gain limits the use these drugs. There are two main isoforms, specific functions each not established. Here we generated mouse lines in which endogenous PPARγ1 PPARγ2 were epitope-tagged interrogate isoform-specific genomic binding, mice...
Abstract Background A previous exploratory analysis of surveillance data at our large academic medical center identified higher CLABSI rates among non-Hispanic Black patients compared to White patients. In the context a growing understanding importance social determinants health (SDOH), we sought better describe those who acquired CLABSI. Methods We conducted retrospective with were admitted one 3 hospitals in system 2022 (1 and 2 community hospitals). was defined using standard NHSN...
Introduction This post hoc analysis evaluated the relationship between objective measures of inflammation and clinical outcomes following 12 weeks certolizumab pegol (CZP) treatment in patients with active axial spondyloarthritis (axSpA). Methods We report proportion achieving ≥50% ≥75% improvements composite outcome disease activity (Axial Spondyloarthritis Disease Activity Score [ASDAS], Bath Ankylosing Spondylitis Index [BASDAI]) (C reactive protein [CRP], spine MRI score [ASspiMRI-a]...
Tyrosine kinase inhibitors (TKIs) induce molecular remission in the majority of patients with chronic myelogenous leukemia (CML), but persistence CML stem cells hinders cure and necessitates indefinite TKI therapy. We report that upregulate expression pleiotrophin (PTN) require cell-autonomous PTN signaling for pathogenesis BCR/ABL+ mice. Constitutive deletion substantially reduced numbers capable initiating vivo. Hematopoietic cell-specific suppressed development mice, suggesting was...
Background A consensus definition for active sacroiliitis by MRI, mentioned in the Assessment of SpondyloArthritis International Society (ASAS) classification criteria axial spondyloarthritis (axSpA), was published 2009 and included a qualitative quantitative MRI cut-off component. In 2021, updates to component were preliminarily proposed. This post hoc analysis part phase 3 open-label C-OPTIMISE study ( NCT02505542 ) explores differences applying preliminary 2021 inflammatory cut-offs on...
Abstract Background Prior research demonstrates Crohn’s disease patients often do well in pregnancy; however, less is known about the risk of flare postpartum period. Methods A retrospective chart review was conducted at a tertiary care inflammatory bowel center. All pregnant women with who were followed period, defined as 6 months after delivery, included. Statistical analysis included χ 2 analysis, Wilcoxon rank sum test, and logistic regression analysis. The primary outcome interest rate...
Background 52-week results from C-axSpAnd demonstrated the safety and efficacy of certolizumab pegol (CZP) in patients with active non-radiographic axial spondyloarthritis (nr-axSpA) objective signs inflammation (sacroiliitis on MRI and/or elevated C-reactive protein levels). Long-term clinical outcomes, including assessments, are evaluated up to 3 years for CZP-treated nr-axSpA. Methods was a phase study comprising 1-year double-blind, placebo-controlled period 2-year open-label follow-up...
Brown adipose tissue (BAT) is a key thermogenic organ whose expression of uncoupling protein 1 (UCP1) and ability to maintain body temperature in response acute cold exposure require histone deacetylase 3 (HDAC3). HDAC3 exists tight association with nuclear receptor corepressors (NCoRs) NCoR1 NCoR2 (also known as silencing mediator retinoid thyroid receptors [SMRT]), but the functions NCoR1/2 BAT have not been established. Here we report that expected, genetic loss (NCoR1/2 BAT-dKO) leads...
Tumor necrosis factor inhibitors (TNFi) are an effective treatment for non-radiographic axial spondyloarthritis (nr-axSpA). To be eligible, however, many authorities require patients with nr-axSpA to show active sacroiliitis on magnetic resonance imaging (MRI) and/or elevated C-reactive protein (CRP) level, possibly resulting in a perception that without both factors have only low responses TNFi treatment. We evaluated clinical certolizumab pegol (CZP) stratified by baseline MRI/CRP...
Abstract Background/Aims Certolizumab pegol (CZP), a PEGylated TNFi without an Fc region, has previously shown efficacy and safety in patients with axial spondyloarthritis (axSpA). EULAR guidelines recommend that tapering of biologic can be considered for sustained remission. The C-OPTIMISE trial (NCT02505542) identified early (<5 years) axSpA remission who may benefit from dose or stopping treatment. Here we report whether reduced CZP maintenance is associated improvements patient...
There is a paucity of data on long-term clinical responses in patients with non-radiographic axial spondyloarthritis (nr-axSpA) based their baseline objective signs inflammation such as MRI or C-reactive protein (CRP) levels. This study reports outcomes up to 3 years the C-axSpAnd trial, including safety follow-up extension (SFE) from Weeks 52 156, stratified by patients' and CRP status. (NCT02552212) was phase 3, multicentre that evaluated certolizumab pegol (CZP) active nr-axSpA who had...
Visceral white adipose tissues (WAT) regulate systemic lipid metabolism and inflammation. Dysfunctional WAT drive chronic inflammation facilitate atherosclerosis. Adipose tissue-associated macrophages (ATM) are the predominant immune cells in WAT, but their heterogeneity phenotypes poorly defined during atherogenesis. The scavenger receptor CD36 mediates ATM crosstalk with other tissue cells, driving Here, we combined single-cell RNA sequencing technique cell metabolic functional assays on...
This study aimed to determine practices that could improve communication and participation in special education classrooms with parents. Special seem have greater difficulty cultivating relationships parents due the complex nature of education. Improved has shown it can a positive effect on student achievement as well between parents, teachers, schools. The classroom was made up all students ranged grades k-1, male/ female, variation intellectual disabilities. school is located near military...
Objective: Evaluate for encephalitis autoantibodies in a group of well-characterized psychosis patients. Background: Autoimmune (AE) commonly presents with psychosis. A recent study from UK identified NMDA-R antibodies 3% patients first-episode Younger may be incorrectly diagnosed as schizophrenia if other features AE are not present. Design/Methods: As part an ongoing multicenter on biomarkers (B-SNIP consortium) over 3,000 probands psychotic disorders, their biological relatives, and...