A5048642442- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Access Control and Trust
- Cryptography and Data Security
- Service-Oriented Architecture and Web Services
- Neuroscience and Neuropharmacology Research
- Cloud Data Security Solutions
- Distributed and Parallel Computing Systems
- Drug Transport and Resistance Mechanisms
- Security and Verification in Computing
- Mobile Agent-Based Network Management
- Electronic Health Records Systems
- Privacy, Security, and Data Protection
- Pharmaceutical studies and practices
- Peer-to-Peer Network Technologies
- Diet and metabolism studies
- Health Systems, Economic Evaluations, Quality of Life
- Internet Traffic Analysis and Secure E-voting
- Genetics and Neurodevelopmental Disorders
- Privacy-Preserving Technologies in Data
- IPv6, Mobility, Handover, Networks, Security
- Neurological disorders and treatments
- Digital Rights Management and Security
- Distributed systems and fault tolerance
- Advanced Database Systems and Queries
Entrust
2024
University of Bristol
1997-2023
Crossword Cybersecurity (United Kingdom)
2023
University of Kent
2012-2022
Nottingham City Hospital
2019
University of Liverpool
2006-2017
University of Greenwich
2017
Walton Centre
2003-2013
Technical University of Munich
2013
Massachusetts Institute of Technology
2013
Two-hundred and seventeen patients from a total population of 343 with arteriovenous malformations, were managed without surgery. Follow up was for mean 10.4 years. Using life survival analyses, there 42% risk haemorrhage, 29% death, 18% epilepsy 27% having neurological handicap by 20 years after diagnosis in unoperated patients.
Summary: As part of a large community‐based study, we retrospectively examined the clinical course epilepsy in an unselected population people who had recent history seizures or were receiving antiepileptic drugs (AEDs). Clinical information was collected from medical records, and about psychosocial functioning obtained by means postal questionnaires sent to identified subjects. The response rate questionnaire 71%. There some deficiencies recording data, which is not unusual since data taken...
Summary: The need for new antiepileptic drugs (AEDs) and more sensitive methods of assessing their efficacy is well recognized. This study was designed to evaluate the safety lamotrigine (LTG), a potential AED develop test outcome measures. A health‐related quality life (HRQL) model developed which contains previously validated measures anxiety, depression, happiness, overall mood, self‐esteem, mastery specifically seizure severity scale with patient‐ caregiver‐based components. HRQL used in...
The MRC Multicentre trial for Early Epilepsy and Single Seizures (MESS) showed a reduced risk of further seizures in patients, whom treatment with antiepileptic drugs was uncertain, who were randomly assigned immediate compared delayed treatment. However, there no evidence an effect on [corrected] long-term remission rates. This study undertaken to assess the role patient characteristics prediction seizure recurrence. will enable decision-making basis perceived benefit reducing initial years...
Summary: Purpose: The increased risk of mortality among people with epilepsy is well documented; are more likely than the general population to die as a result an accident. Data about incidence nonfatal accidents and associated factors not so readily available, even though such common fatal injuries. We report proportion who sustain various injuries during seizure key variables predicting injury. Methods: Questionnaires were mailed unselected, community‐based patients epilepsy. questionnaire...
A strong pharmacogenetic association has been reported in Chinese patients between human leukocyte antigen (HLA)-B*1502 and carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS).We have genotyped the HLA-B alleles 56 Caucasian with varying severities of CBZ hypersensitivity 43 controls on without adverse effects.None our (including two blistering skin rashes) were positive for HLA-B*1502 allele. HLA-B*0702 allele may protect against severe but warrants further study. Of secondary...
Recent studies have shown that most newly diagnosed epileptic patients can be satisfactorily treated with a single antiepileptic drug. We therefore undertook prospective randomised pragmatic trial of the comparative efficacy and toxicity four major drugs, utilised as monotherapy in patients. Between 1981 1987 243 adult aged 16 years or over, referred to two district general hospitals minimum previously untreated tonic-clonic partial without secondary generalised seizures were randomly...
The epilepsies are a group of disorders characterised by recurrent seizures caused episodes abnormal neuronal hyperexcitability involving the brain. Up to 60 million people affected worldwide and genetic factors may contribute aetiology in up 40% patients. most common human display complex pattern inheritance. These categorised as idiopathic absence detectable structural or metabolic abnormalities. Juvenile myoclonic epilepsy (JME) is distinctive variety familial generalised (IGE) with...
Objectives – To compare topiramate (TPM) with investigator's choice of carbamazepine (CBZ) or valproate (VPA) for initial treatment in patients newly diagnosed epilepsy. Material and methods In epilepsy within previous 3 months, investigators selected CBZ (600 mg/day) VPA (1250 as preferred therapy based on the patient's clinical presentation. Based investigators' choice, (n=613) were assigned to branch. Within each branch, randomized double-blind traditional antiepileptic drugs (CBZ VPA),...
Three patients with a type of myoclonus produced by intention and somatosensory stimulation were studied electrophysiologic techniques. Each jerk typically affected only few contiguous muscles; agonist antagonist muscles activated simultaneously simple electromyographic (EMG) burst lasting 10 to 30 msec. Cranial nerve in an order indicating that the signal produce traveled down brainstem. In action-induced jerks negative transient electroencephalogram (EEG) from contralateral sensorimotor...
This paper describes the output of PERMIS project, which has developed a role based access control infrastructure that uses X.509 attribute certificates (ACs) to store users' roles. All decisions are driven by an authorization policy, is itself stored in certificate, thus guaranteeing its integrity. ACs can be one or more LDAP directories, making them widely available. Authorization policies written XML according DTD been published at XML.org. The Access Control Decision Function (ADF) Java...
Administration of carbamazepine (CBZ) causes hypersensitivity reactions clinically characterized by skin involvement, eosinophilia, and systemic symptoms. These have an immune etiology; however, the role T cells is not well defined. The aim this study was to characterize specificity, phenotype, cytokine profile CBZ-specific derived from hypersensitive individuals. Proliferation blood lymphocytes measured using lymphocyte transformation test. cell clones were generated serial dilution in...
Gabapentin is widely approved as add-on therapy for epilepsy treatment partial seizures with and without secondary generalization. To investigate the efficacy of gabapentin administered monotherapy in patients newly diagnosed epilepsy, a randomized double-blind trial was performed.Eligible were to receive one three masked doses (300, 900, or 1,800 mg/day) open-label carbamazepine (600 kept daily seizure diaries throughout study. After titration, entered 24-week evaluation phase. Patients...
Summary: Purpose: Epilepsy is a common neurological condition, with significant resource implications for the health services, but few studies to date have examined uptake and costs of care this condition. As part large prevalence study epilepsy conducted in one U.K. Health Region, we investigated both direct indirect measured valued costs. Methods: Data about service use were obtained from primary physician records patient questionnaires. Unit each item generated several sources. Results:...