A5024508332- Dementia and Cognitive Impairment Research
- Cognitive Functions and Memory
- Blood Pressure and Hypertension Studies
- Health, Environment, Cognitive Aging
- Health disparities and outcomes
- Cognitive Abilities and Testing
- Alzheimer's disease research and treatments
- Lipoproteins and Cardiovascular Health
- Genetics, Aging, and Longevity in Model Organisms
- Cerebrovascular and Carotid Artery Diseases
- Hypothalamic control of reproductive hormones
- Memory and Neural Mechanisms
- Child Nutrition and Water Access
- Health, psychology, and well-being
- Traumatic Brain Injury and Neurovascular Disturbances
- Education, Achievement, and Giftedness
- Stress Responses and Cortisol
- Disaster Response and Management
- Substance Abuse Treatment and Outcomes
- Neurological Disease Mechanisms and Treatments
- Regulation of Appetite and Obesity
- Neuroscience and Neuropharmacology Research
- Alcohol Consumption and Health Effects
- Neuropeptides and Animal Physiology
- Genetic Associations and Epidemiology
Universidade de São Paulo
2020-2025
Global Brain Health Institute
2024
University of California, San Francisco
2024
Universidade Brasil
2023
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2019-2023
<b><i>Introduction:</i></b> Twelve modifiable risk factors (RFs) account for 40% of dementia cases worldwide. However, limited data exist on such in middle- and low-income countries. We aimed to estimate the population-attributable fractions (PAFs) 12 RFs Argentina, assessing changes over a decade exploring socioeconomic sex influences. <b><i>Methods:</i></b> conducted cross-sectional analyses from Argentinian surveys 2009, 2015, 2018,...
Heavy alcohol consumption is a major global health concern linked to increased morbidity and mortality. However, the long-term impact of excessive on cognitive abilities dementia-related neuropathology unclear. The aim this study was analyze association between age-related neuropathologic outcomes in population-based autopsy study. This cross-sectional used data from Biobank for Aging Studies, classifying participants as never, moderate, heavy, or former drinkers. Alzheimer disease pathology...
Abstract Background Apolipoprotein E ε4 allele (APOE-ε4) is the main genetic risk factor for late-onset Alzheimer’s disease (AD) and may impact cognitive function also via other neuropathological lesions. However, there limited evidence available from diverse populations, as APOE associations with dementia seem to differ by race. Therefore, we aimed evaluate pathways linking APOE-ε4 abilities through AD non-AD neuropathology in an autopsy study admixed sample. Methods Neuropathological...
Socioeconomic factors are important contributors to brain health. However, data from developing countries (where social inequalities the most prominent) still scarce, particularly about hypertensive individuals.To evaluate relationship between socioeconomic index, cognitive function, and cortical volume, as well determine whether white matter hyperintensities mediators of association index with function in individuals.We assessed 92 participants (mean age = 58±8.6 years, 65.2%female)....
Background Hypertension is associated with working memory (WM) impairment. However, the benefits of Cogmed WM training for hypertensive population are unknown. Therefore, we aimed to evaluate Cogmed’s effects on performance individuals executive function (EF) Methods We included 40 patients (aged 40–70 years, 68% female) EF They were randomized in a 1:1 ratio receive 10 weeks adaptive or non-adaptive control based online games. The primary outcome was performance. secondary outcomes verbal...
The rise in dementia prevalence, particularly lower- and middle-income countries (LMIC), places a significant burden on healthcare systems. However, comprehensive data hospital admissions are scarce.
Abstract Background Late‐life depression (LLD) is a risk factor for cognitive impairment. Some studies have shown an association between higher amyloid‐beta (Aβ) burden, known marker of Alzheimer’s Disease (AD), and LLD, but research findings are mixed. We performed systematic review meta‐analysis to compare the Aβ burden cognitively unimpaired subjects with without LLD. Method searched MEDLINE, Embase, ScienceDirect comparing LLD patients controls (molecular imaging and/or fluid‐biomarker...
Abstract Background Hypertension is a midlife modifiable risk factor for dementia. Uncontrolled hypertension related to brain damage that could result in cognitive impairment, and one way of evaluating uncontrolled through life assessing left ventricular hypertrophy (LVH). Previous imaging studies have shown relationship between LVH impairment. However, no previous study has evaluated this association using direct measurements obtained autopsy. Furthermore, little known about diverse...
Abstract Background Approximately 40% of global dementia cases are associated with 12 modifiable risk factors (less education, hearing loss, hypertension, obesity, smoking, depression, social isolation, physical inactivity, diabetes, alcohol excess, air pollution, and traumatic brain injury). However, the number people these differs between populations. Latin American countries differ in socioeconomic geographic aspects and, therefore, prevalence. Our goal was to determine...
Abstract Background Osteoporosis is associated with an increased risk of dementia (Zhang, P. et al., 2022). The Fracture Risk Assessment Tool (FRAX) calculates the hip fracture using a series clinical variables, even in absence bone density knowledge. A higher FRAX scores indicates for osteoporosis. Some studies suggest that individuals are also at cognitive decline and dementia, less evidence from low‐ middle‐income countries (LMIC). We aim to evaluate association between score impairment...
Individuals with high scores of perceived stress (PS) are more likely to develop arterial hypertension (AH) than those low levels stress. In addition this, AH and both independent risk factors for executive function (EF) impairment worse quality life (QoL). Therefore, strategies control cope emotional paramount importance. However, less is known about the association PS EF, QoL, coping in individuals hypertension. This study aimed evaluate EF performance, use, QoL a sample hypertensive...
Abstract Background Apolipoprotein E ε4 allele (APOE‐ε4) is the main genetic risk factor for dementia. APOE‐ε4 also associated with Alzheimer’s disease (AD) pathology, cerebrovascular disease, and non‐AD neurodegenerative pathologies. Although may influence cognitive impairment through these pathways, less evidence available from diverse populations, considering that APOE genotype associations seem to vary by race. Therefore, we aimed evaluate pathways linking cognition AD neuropathology in...
Working memory (WM) has been extensively explored in the field of cognitive neuroscience, and several programs have developed to train this ability different clinical conditions. Among them, Cogmed stands out, since its effects shown beneficial for many populations, but few studies evaluated training on brain function. In addition, none these were with hypertensive patients who are known deficits executive functions, including WM. Therefore, aim study was evaluate neuronal activation during...
Introduction: Hypertension is a risk factor for working memory (WM) impairment, and the Cogmed training has been tested as non-pharmacological alternative to WM rehabilitation. However, benefits of hypertensive population are unknown. Therefore, we aimed evaluate Cogmed’s effects on performance individuals with executive function (EF) impairment. Methods: We included 40 patients (aged 70 years, 68% female) EF They were randomized in 1:1 ratio receive ten weeks adaptive or non-adaptive...