A5062980099- Traumatic Brain Injury and Neurovascular Disturbances
- Mathematical and Theoretical Epidemiology and Ecology Models
- Evolution and Genetic Dynamics
- Cerebrospinal fluid and hydrocephalus
- Optical Imaging and Spectroscopy Techniques
- Ecosystem dynamics and resilience
- Neurosurgical Procedures and Complications
- Complex Systems and Time Series Analysis
- Mosquito-borne diseases and control
- Cognitive Functions and Memory
- Dementia and Cognitive Impairment Research
- Statistical Mechanics and Entropy
- Cerebrovascular and Carotid Artery Diseases
- Non-Invasive Vital Sign Monitoring
- Nonlinear Dynamics and Pattern Formation
- Neural dynamics and brain function
- Chaos control and synchronization
- Malaria Research and Control
- Acute Ischemic Stroke Management
- Evolutionary Game Theory and Cooperation
- COVID-19 epidemiological studies
- Heart Rate Variability and Autonomic Control
- Cognitive Abilities and Testing
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
Universidade Estadual Paulista (Unesp)
2019-2024
Universidade de São Paulo
2008-2020
University of Cambridge
2015-2018
Felix Platter-Hospital
2017
Vita Care (Brazil)
2016
Addenbrooke's Hospital
2016
Universidade de Ribeirão Preto
2011-2014
Objectives: In severe traumatic brain injury, cerebral perfusion pressure management based on cerebrovascular reactivity index has the potential to provide a personalized treatment target improve patient outcomes. So far, methods have focused identifying “one” autoregulation-guided target—called “cerebral optimal”. We investigated whether autoregulation range—which uses continuous estimation of “lower” and “upper” limits (assessed with index)—has prognostic value. Design: Single-center...
Elevation of intracranial pressure (ICP) may occur in many diseases, and therefore the ability to measure it noninvasively would be useful. Flow velocity signals from transcranial Doppler (TCD) have been used estimate ICP; however, relative accuracy these methods is unclear. This study aimed compare four previously described TCD-based with directly measured ICP a prospective cohort traumatic brain-injured patients. Noninvasive (nICP) was obtained using following methods: 1) mathematical...
BACKGROUND: Increasing evidence links postoperative cognitive dysfunction (POCD) to surgery and anesthesia. POCD is recognized as an important neuropsychological adverse outcome in surgical patients, particularly the elderly. This prospective cohort study aimed investigate whether associated with impaired intraoperative cerebral autoregulation oxygenation, increased levels of biomarkers brain injury. METHODS: Study subjects were patients ≥65 years age scheduled for major noncardiac surgery....
Many demographic and physiological variables have been associated with TBI outcomes. However, small sample sizes, making spurious inferences is possible. This paper explores the effect of sizes on statistical relationships between patient (both demographic) outcome. Data from head-injured patients monitored arterial blood pressure, intracranial pressure (ICP) outcome assessed at 6 months were included in this retrospective analysis. A univariate logistic regression analysis was performed to...
A characteristic feature of complex healthy biological systems is the ability to react and adapt minute changes in environment. This ‘complexity’ manifests itself highly irregular patterns various physiological measurements. Here, we apply Multiscale Entropy (MSE) analysis assess complexity systemic cerebral near-infrared spectroscopy (NIRS) signals a cohort 61 critically ill preterm infants born at median (range) gestational age 26 (23–31) weeks, before 24 h life. We further correlate these...
Abstract Aim Many clades display the macroevolutionary pattern of a negative relationship between standing diversity and diversification rates. Competition among species has been proposed as main mechanism that explains this pattern. However, we currently lack empirical insight into how effects individual‐level ecological interactions scale up to affect diversification. Here, investigate clade shows evidence for diversity‐dependent in fossil record test whether clade's modern communities...
We consider several one-species population dynamics model with finite and infinite carrying capacity, time dependent growth effort rates solve them analytically. show that defining suitable scaling functions for a given time, one is able to demonstrate their ratio respect its initial value universal. This independent from the condition parameters. Although rate does not break universality it produces transition between species extinction survival. A general formula furnished obtain functions.
In this work we propose an alternative model of the spread tuberculosis (TB) and emergence drug resistance due to treatment with antibiotics. We implement simulations by agent-based computational approach where spatial structure is taken into account. The occurs according probabilities defined interactions among individuals. was validated reproducing results already known from literature in which different regimes yield resistance. patterns TB can be visualized at any time system evolution....
This study aimed to compare four non-invasive intracranial pressure (nICP) methods in a prospective cohort of hydrocephalus patients whose cerebrospinal fluid dynamics was investigated using infusion tests involving controllable test-rise ICP. Cerebral blood flow velocity (FV), ICP and arterial (ABP) were recorded 53 diagnosed for hydrocephalus. Non-invasive based on: (1) interaction between FV ABP black-box model (nICP_BB); (2) diastolic (nICP_FVd); (3) critical closing (nICP_CrCP); (4)...
Functional magnetic resonance imaging (fMRI) data analysis has been carried out recently in the framework of information theory, by means Shannon entropy. As a natural extension, method based on generalized Tsallis entropy was developed to event-related (ER-fMRI), where brief stimulus is presented, followed long period rest. The new technique aims for spatial localization neuronal activity due specific task. This does not require priori hypothesis hemodynamic response function (HRF) shape...
The Kullback-Leibler distance (or relative entropy) is applied in the analysis of functional magnetic resonance (fMRI) data series. Our study designed for event-related (ER) experiments, where a brief stimulus presented and long period rest followed. In particular, this entropy used as measure "distance" between probability distributions p1 p2 signal levels related to non-stimulus. order avoid undesirable divergences distance, small positive parameter delta introduced definition functions...
DC is supported by a Cambridge Commonwealth, European & International Trust Scholarship, University of Cambridge. JD Woolf Fisher Scholarship. XL Gates GVV an A. G. Leventis Foundation and Charter Studentship from St Edmund’s College, SM GF are the Pan-American Health Organization. MC partially NIHR Brain Injury Healthcare Technology Co-operative, Cambridge, UK.