A5059766668- Traumatic Brain Injury and Neurovascular Disturbances
- Venomous Animal Envenomation and Studies
- High Altitude and Hypoxia
- Nicotinic Acetylcholine Receptors Study
- Heparin-Induced Thrombocytopenia and Thrombosis
- Neurological Disease Mechanisms and Treatments
- Cardiovascular and Diving-Related Complications
- Acute Ischemic Stroke Management
- Ion channel regulation and function
- Blood Pressure and Hypertension Studies
- Cerebrovascular and Carotid Artery Diseases
- Sodium Intake and Health
- Veterinary Pharmacology and Anesthesia
- Intracranial Aneurysms: Treatment and Complications
- Neurological Disorders and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Venous Thromboembolism Diagnosis and Management
- Animal testing and alternatives
- Leech Biology and Applications
- Caveolin-1 and cellular processes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Natural Antidiabetic Agents Studies
- Respiratory Support and Mechanisms
- T-cell and B-cell Immunology
- Cholinesterase and Neurodegenerative Diseases
Institute of Bioorganic Chemistry
2016-2024
To preclinically study the effectiveness of new antihypertensive drugs, various animal hypertension models are used. However, most them do not correspond to primary hypertension, which develops in people with age. We used male Wistar rats 4, 10, 12 and 18 months old. The animals were divided according systolic blood pressure (SBP) into normotensive (SBP ≤ 114 mmHg) or hypertensive ≥ 115 mmHg). Within animals, two cohorts distinguished—with SBP below above 125 mmHg. received 100 µg/kg...
The success in treatment of venous thromboembolism and acute coronary syndromes using direct thrombin inhibitors has stimulated research aimed at finding a new anticoagulant from haematophagous organisms. This study deals with the comparison between hirudin-1 Hirudomedicinalis(desirudin), being first-known most well-studied natural anticoagulant, along recombinant analogs haemadin leech Haemadipsa sylvestris, variegin tick Amblyomma variegatum, anophelin Anopheles albimanus. These...
Introduction: Pharmacokinetic characteristics as well cognitive-enhancing nootropic activity of latrepirdine (Dimebon ® ) in relationship with its polymorphic forms have been studied SD and Wistar rats. Methods: The pharmacokinetics six polymorphs (A, B, C, D, E, F) were male rats after 7 days oral administration corn oil at a dose 10 mg/kg once day. Blood brain samples taken on the 7th day 15 min, 30 60 min 120 analyzed for content by LC-MS. effect was female 9 mg/kg, prior scopolamine, an...
A structural analogue of the DSIP, peptide KND, previously showed higher detoxification efficacy upon administration cytotoxic drug cisplatin, compared to DSIP. DSIP and KND were investigated using model acute myocardial infarction in male SD rats focal stroke C57Bl/6 mice. significant decrease area was registered KND-treated animals relative saline-treated control (19.1 ± 7.3% versus 42.1 9.2%). The brain volume significantly lower intranasally treated with (7.4 3.5% 12.2 5.6%). Injection...
The development of novel anticoagulants requires a comprehensive investigational approach that is capable characterizing different aspects antithrombotic activity. necessary experiments include both in vitro assays and studies on animal models. required vivo approaches the assessment pharmacokinetic pharmacodynamic profiles hemorrhagic effects. Comparison with mechanisms action administration types unification experiment scheme its adaptation to existing laboratory conditions. rodent...
: Intratracheal administration of bleomycin (BLM) to laboratory rodents is a standard, widely used technique model pulmonary fibrosis (PF). BLM, as modeling agent, produced mainly in the form two salts-sulfate and chloride. We compared results PF SD rats by intratracheal BLM sulfate
Background and Objectives: Mutual effect of the preliminary therapeutic intranasal treatment SD rats with DSIP (8 days) on outcome focal stroke, induced intraluminal middle cerebral occlusion (MCAO), was investigated. Materials Methods: The groups were following: MCAO + vehicle, DSIP, SHAM-operated. or vehicle applied nasally 60 (±15) minutes prior to for 7 days after reperfusion at dose 120 µg/kg. battery behavioral tests performed 1, 3, 7, 14, 21 MCAO. Motor coordination balance bilateral...
A short synthetic peptide from the C-terminal part of caveolin-3 structure was tested for experimental autoimmune encephalomyelitis (EAE) treatment in rats. The structure–function similarity established between novel pCav3 and well-known immunomodulator immunocortin determined pCav3’s ability to reduce EAE symptoms Dark Agouti (DA) rats injected with (500 µg/kg). found interfere proliferation lymphocytes extracted LNs DA primed homogenate injection, IC50 = 0.42 μM (2.35 mcg/mL). affected a...
The study focused on the effect of dipyridamole (kurantil) administered for 3 days prior to a surgery blood pressure (BP) and cerebral flow during global ischemia followed by reperfusion in SD rats. Global was modeled bilateral occlusion carotid arteries with simultaneous withdrawal 30% circulating volume (CBV). BP were recorded throughout operation. Results. During experiment, time-related changes did not differ between kurantil group vehicle group. drop response artery statistically...
В исследовании изучали влияние дипиридамола (курантила) при введении в течение 3 дней перед операцией на показатели артериального давления (АД) и мозгового кровотока период глобальной ишемии головного мозга с последующей реперфузией у крыс SD. Глобальную ишемию моделировали путем билатеральной окклюзии сонных артерий одновременным взятием крови объеме 30% от объема циркулирующей (ОЦК). Показатели АД регистрировали протяжении всей операции. Результаты. Динамика изменения ходе эксперимента не...