A5035634644- Advanced Polymer Synthesis and Characterization
- biodegradable polymer synthesis and properties
- RNA Interference and Gene Delivery
- Supramolecular Chemistry and Complexes
- Advanced biosensing and bioanalysis techniques
- Polymer Surface Interaction Studies
- Luminescence and Fluorescent Materials
- Synthesis and properties of polymers
- Electrospun Nanofibers in Biomedical Applications
- Polyoxometalates: Synthesis and Applications
- Supramolecular Self-Assembly in Materials
- DNA and Nucleic Acid Chemistry
- Blood properties and coagulation
- Lipid Membrane Structure and Behavior
- Diatoms and Algae Research
- Connective tissue disorders research
- Molecular Sensors and Ion Detection
- Transgenic Plants and Applications
- Marine Biology and Environmental Chemistry
- Silicone and Siloxane Chemistry
- Metal-Organic Frameworks: Synthesis and Applications
- Microbial Inactivation Methods
- Bacteriophages and microbial interactions
- Covalent Organic Framework Applications
- Drug Solubulity and Delivery Systems
Sorbonne Université
2011-2024
Institut Parisien de Chimie Moléculaire
2008-2022
Centre National de la Recherche Scientifique
2008-2022
UPMC Health System
2014-2015
3M (United States)
2015
Laboratoire de Chimie des Polymères Organiques
2012-2015
Institut Universitaire de France
2014
Inserm
2008-2011
Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques
2011
Université Paris Cité
2008-2010
Abstract Aqueous emulsion polymerizations of styrene were performed in the presence a macromolecular reversible addition‐fragmentation chain transfer (RAFT) agent (macroRAFT) composed acrylic acid (AA) and poly(ethylene oxide) methyl ether acrylate (PEOA), end‐capped by reactive dodecyl trithiocarbonate group (P(AA‐ co‐ PEOA)‐TTC). The influence stirring speed or different amounts divalent salt, CaCl 2 , investigated this polymerization‐induced self‐assembly process, which spherical...
A bridge to assemble: Cyclodextrins bridged with an ammonium linker bearing a hydrophobic substituent can efficiently form supramolecular polymers and avoid the competing self-inclusion head-to-head processes. Furthermore, self-assembling cyclodextrin derivative interacts in highly cooperative manner DNA, as demonstrated by compaction experiments. It also cooperatively siRNA allows its transfection. As service our authors readers, this journal provides supporting information supplied...
Abstract We report the synthesis of first organo‐POM with thermoresponsive properties. Our concept will provide chemists a new tool to design POMs whose solubility is reversibly controllable through an external stimulus. POM–polymer TBA 7 [POM]‐poly( N,N ‐diethylacrylamide) (POM–PDEAAm), was prepared by grafting PDEAAm‐NH 2 (obtained RAFT polymerization) onto activated Dawson acyl‐POM, α ‐[P W 17 O 61 SnCH CH C(O)] 6− . Extensive MS analysis used monitor chain‐functionalization steps and...
Bio-hybrid networks are designed based on the self-assembly of surface-engineered collagen–silica nanoparticles. Collagen triple helices can be confined surface sulfonate-modified silica particles in a controlled manner. This gives rise to hybrid building blocks with well-defined diameters and potentials. Taking advantage self-assembling properties collagen, further built-up solution. The structural specific recognition collagen fibrils well-preserved within assembly. A combination...
The phenylurea moiety is a ubiquitous synthon in supramolecular chemistry because it contains strong complementary hydrogen bonding groups and synthetically very accessible. Here we investigate the possibility to strengthen self-association by conformational preorganization of moiety. In fact, show that possible strongly enhance intermolecular interactions between bonded aromatic bis-ureas substitution at ortho positions groups. Ortho substituents enforce noncoplanar conformation urea phenyl...
β-Cyclodextrin conjugated to adamantane forms self-inclusion complexes instead of supramolecular polymers.
Abstract Background Amphiphilic triblock copolymers such as the polyethylene oxide‐polypropylene oxide‐polyethylene oxide L64 (PEO 13 ‐PPO 30 ‐PEO ) significantly increase transgene expression after injection of DNA/polymer mixtures into skeletal muscles. To better understand way act, we studied behaviour different poloxamers, including L64, both in vitro and vivo . Methods The transfection activity five that differ either by their molecular weight or hydrophilic/hydrophobic balance was...
The controlled/living free-radical copolymerization of vinylidene chloride (VDC) with methyl acrylate (MeA) or acrylic acid (AA) was studied by the reversible addition–fragmentation chain transfer (RAFT) technique using a trithiocarbonate RAFT agent. reactions were performed in 1,4-dioxane solution at 30 °C and led to good control high chain-end functionality. P(VDC-co-MeA)-b-PAA, PAA-b-P(VDC-co-MeA), PAA-b-P(VDC-co-AA) amphiphilic block copolymers then prepared same conditions, starting...
Abstract Branched and star‐branched polymers were successfully synthesized by the combination of two successive controlled radical polymerization methods. A series linear star poly( n ‐butyl acrylate)‐ co ‐poly(2‐(2‐bromoisobutyryloxy) ethyl acrylate) statistical copolymers, P( BA‐ ‐BIEA) x , first nitroxide‐mediated (NMP at T > 100 °C). The subsequent acrylate single electron transfer‐living (SET‐LRP = 25 °C), initiated from brominated sites copolymer, produced branched or (P BA). Both...
We revisit the equilibrium phase diagram of much-studied model supramolecular polymer, 2,4-bis(2-ethylhexylureido)toluene (EHUT) in nonpolar solvents and provide unambiguous evidence a much richer behavior, characterized by four distinct regimes. Typically, two types self-assembled structures are formed: tubes (filaments) at higher (lower) concentrations lower (higher) temperatures. The tube structure forms viscoelastic solutions that had been rheology, however, without detailed analysis...
Cyclodextrine, die von einem Ammoniumlinker mit hydrophoben Substituenten überbrückt sind, können effizient supramolekulare Polymere bilden und den konkurrierenden Selbsteinschluss Kopf-zu-Kopf-Prozesse vermeiden. Die selbstorganisierten Cyclodextrinderivate wechselwirken außerdem in hoch kompetitiver Weise DNA, wie durch Kompaktierungsexperimente nachgewiesen wird, sowie siRNA, dessen Transfektion sie ermöglichen. As a service to our authors and readers, this journal provides supporting...
Abstract Background Nonviral gene therapy still suffers from low efficiency. Methods that would lead to higher expression level of longer duration be a major advance in this field. Lipidic vectors and physical methods have been investigated separately, both induced improvement. We sought combine chemical methods. Cationic or anionic lipids can potentially destabilize the cell membrane could consequently enhance delivery by method such as electrotransfer. A plasmid model encoding luciferase...
Silanization of biomacromolecules has emerged as a fruitful approach to prepare hybrid biohydrogels. However, very little is known about interactions between organosilanes and biopolymers in solution. Here we focused on fibrin, protein interest the biomedical field, whose self-assembly process resulting gel structure are highly sensitive experimental conditions. Three main silanes were selected decipher relative influence silanol groups organic functions. Whereas no denaturation was...
This communication describes the synthesis of a triple acid-functionalized RAFT agent and its use to prepare well-defined 3-arm star polymers N,N-dimethylacrylamide (DMAc). A simple esterification reaction allowed convenient integration three electron-rich naphthalene recognition units on platform subsequently elaboration end-decorated telechelic PDMAc. functionalized polymer was further exploited build hydrogel with complementary homoditopic host unit featuring tetracationic macrocycle...
A functionnalized cyclodextrin can self-co-assemble with ds-DNA to form fibres of well-defined architecture. We have also determined the molecular structure this abiotic assembly using cryo-EM and 3D image reconstruction.
Copolymers with two distinguished reactive repeating units are of great interest, as such copolymers might open the possibility obtaining selective and/or consequent different chemical structures and properties. In present work, based on active esters (pentafluorophenyl methacrylate p-nitrophenyl methacrylate) varied compositions were synthesized by Cu(0)-mediated reversible deactivation radical polymerization. This polymerization technique allows preparation high to quantitative conversion...