A5035936588- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Cancer Research and Treatments
- Acute Lymphoblastic Leukemia research
- Phagocytosis and Immune Regulation
- Cell death mechanisms and regulation
- Cancer, Lipids, and Metabolism
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- RNA modifications and cancer
- Oral Health Pathology and Treatment
- Reproductive tract infections research
- NF-κB Signaling Pathways
- Pain Management and Opioid Use
- Epigenetics and DNA Methylation
- Selenium in Biological Systems
- Toxin Mechanisms and Immunotoxins
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Effects of Radiation Exposure
- Melanoma and MAPK Pathways
Massachusetts General Hospital
2022-2024
Zhejiang University
2024
Stomatology Hospital
2017-2024
Harvard University
2022-2023
Central South University
2017-2023
Third Xiangya Hospital
2023
Xiangya Hospital Central South University
2020
University of Pittsburgh
2012
Emory University
1995-2010
Huazhong University of Science and Technology
2010
The mitogen-activated protein kinase (MAPK) signaling pathway is associated with tumor cell proliferation, differentiation, apoptosis, angiogenesis, invasion and metastasis. present review assesses the involvement of MAPK in oral cancer progression based on analysis individual sub-pathways their mechanisms action. regulation this for targeted therapy explored challenges confronting this, as well corresponding potential solutions, are discussed. Exploring an emphasis its components,...
Ultra-high dose rate irradiation has been reported to protect normal tissues more than conventional irradiation. This tissue sparing termed the FLASH effect. We investigated effect of proton on intestine as well hypothesis that lymphocyte depletion is a cause A 16 × 12 mm2 elliptical field with ~120 Gy/s was provided by 228 MeV pencil beam. Partial abdominal delivered C57BL/6j and immunodeficient Rag1−/−/C57 mice. Proliferating crypt cells were counted at 2 days post exposure, thickness...
Adding losartan (LOS) to FOLFIRINOX (FFX) chemotherapy followed by chemoradiation (CRT) resulted in 61% R0 surgical resection our phase II trial patients with locally advanced pancreatic cancer (LAPC). Here we identify potential mechanisms of benefit assessing the effects neoadjuvant LOS on tumor microenvironment.
Members of the DTX (Deltex) family act as Notch signaling modifiers and may also regulate transcription through interactions with specific factors. proteins have a basic N terminus; central proline-rich region; C-terminal RING finger domain, motif often found in ubiquitin-protein isopeptide ligases (E3). Recently, we identified characterized unique diffuse large B-cell lymphoma risk-related gene named BAL (B aggressive lymphoma). Using yeast two-hybrid screen for BAL-binding partners, now...
The positional relationship between the mandibular canal and corresponding third molars is a key anatomic factor of inferior alveolar nerve (IAN) injury. aim present study to classify three-dimensional molar on cone-beam computed tomography (CBCT) images.This used CBCT images molars. 749 patients (1296 molars) were analyzed draw up classification.On total 1296 molars, relative roots was apical side (88.1%), followed by buccal (7.9%), lingual (3.5%), then (0.5%). Ninety-five (7.1%) had close...
It is widely accepted that oral squamous cell carcinoma (OSCC) a major contributor to the incidence and mortality of neck head cancer. Tropomyosin-1 (TPM1), which expressed at low level, has been considered prominent tumor-suppressing gene in variety solid tumors, although precise mechanism TPM1 OSCC progression remains unknown. We found expression levels decreased patients lines. The overall cancer-specific survival who exhibited were inferior those had high levels. was also suffered from...
AIMS--To determine the cellular origin of most potent cytokine present in Hodgkin9s disease, transforming growth factor (TGF) beta, polycellular population tissue was studied using situ hybridisation. METHODS--A biotin labelled oligo-complementary DNA (cDNA) constructed according to previously determined sequence for TGF beta 1 cDNA. Forty three frozen and paraffin wax embedded samples replaced by disease or non-Hodgkin9s lymphoma, Reed-Sternberg cell lines, one Ki1 positive lymphoma line,...
Arecoline, the major active ingredient of betel nut, is involved in pathogenesis oral submucous fibrosis. However, underlying mechanism this remains unclear. In study, we found that arecoline suppresses cell proliferation HaCaT epithelial and induces cycle arrest at G1/S phase with an IC50 50 μg/mL. Furthermore, reduces protein level cyclin D1, but it has no effect on its mRNA stability, implying may modulate translation D1. We also observed downregulation Akt/mTOR signaling pathway after...
We identified and sequenced a segment of Chlamydia trachomatis chromosomal DNA that shows homology to the Escherichia coli spc distal region S10 ribosomal protein (r-protein) operons. Its sequence revealed high degree nucleotide operon context conservation with E. r-protein genes. The C. spec contains genes for L14, L24, L5, S8, L6, L18, S5, L15, Sec Y along r-proteins L16, L29, S17 operon. two operons are separated by 16-bp intragenic which no transcription signals. However, putative...
Oral submucous fibrosis (OSF) is a chronic and progressive disease. Arecoline, present in betel nuts, has been proposed as vital aetiological factor. However, the underlying mechanism remains unclear.This research elucidates expression of tropomyosin-1 (TPM1) its regulation HaCaT cells treated with arecoline.HaCaT were assigned into three groups: (1) Control; (2) Treated arecoline (0.16 mM) for 48 h (3) transfected small interfering RNA (siRNA) TPM1 (50 nM) h. CCK8, cell cycle, apoptosis...
TRAF1 is a member of the TRAF family, which plays important roles in signal transduction that mediate cell life and death immune response, inflammatory malignant diseases. It known transcription inducible by various cytokines, but little about regulation its mRNA translation. In present study, we demonstrated human has an unusually long 5′-UTR contains internal ribosome entry segment (IRES) regulating By performing gene transfection reporter assays, revealed this IRES sequence located within...
Abstract Background Immunotherapy is a crucial therapeutic approach in oncology. However, most patients with head and neck squamous cell carcinoma (HNSCC) do not derive benefit from immunotherapy. Vascular endothelial growth factor (VEGF)/VEGF Receptor 2 (VEGFR2) signaling pathway one of the important pathways regulating angiogenesis tumor. The combination immunotherapy anti-angiogenic therapy considered to improve efficacy correlation between VEGF tumor immune microenvironment HNSCC...
We describe the cloning and sequence analysis of region surrounding gene for alpha subunit RNA polymerase from Chlamydia trachomatis. This contains genes proteins in order SecY, S13, S11, alpha, L17, which are equivalent to Escherichia coli Bacillus subtilis r proteins. The incorporation chlamydial protein into E. holoenzyme rather than its truncated variant lacking amino terminus suggests existence structural conservation among subunits distantly related genera.
Chemotaxis of blood monocytes into the vessel wall together with change relative content extracellular matrix (ECM) proteins at sites predilection is an early cellular marker atherogenesis. To examine influence ECM on secretion chemoattractants by endothelial cells (EC), porcine EC were seeded gelatin (G), fibronectin (Fn) and fibrinogen (Fg). After 24 h G Fn showed histiotypic 'cobblestone'-morphology whereas Fg did not. Chemotactic activity for in supernatants from was more than two-fold...
Abstract Patients with metastatic breast cancer (MBC) have a dismal prognosis, 5-year survival rate of only 26%. The inadequate infiltration immune cells targeting the tumor microenvironment (TME) is key factor contributing to this low rate. Immune effector cells, including CD8+ cytotoxic T NKT and NK play crucial role in cells. activation relies on presence conventional type I dendritic (cDC1), which present tumor-specific antigenic peptides their surface. Recent studies identified...
Tooth movement induced orofacial pain is the most cited negative effect during orthodontic treatment, while treatment options without side effects are limited. The differential expression of pain-related genes due to DNA methylation and demethylation instrumental in pain. purpose study was evaluate profiling CpG islands (CGI) CGI shores promoter regions trigeminal ganglions (TG) tooth rats, thus further insight regulation An rat model constructed by ligating coil springs between incisor...
<p>Venn plots and selected GSEA pathways.</p>