A5022736431- Enzyme Structure and Function
- Heat shock proteins research
- Genetic Associations and Epidemiology
- Pharmacogenetics and Drug Metabolism
- Lipoproteins and Cardiovascular Health
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cardiovascular Function and Risk Factors
- Endoplasmic Reticulum Stress and Disease
- Agriculture and Biological Studies
- Protein Structure and Dynamics
- Atrial Fibrillation Management and Outcomes
- Pharmaceutical Economics and Policy
- Glycosylation and Glycoproteins Research
- Carbohydrate Chemistry and Synthesis
- Redox biology and oxidative stress
- Blood Coagulation and Thrombosis Mechanisms
- Pharmaceutical studies and practices
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Invertebrate Immune Response Mechanisms
- Agricultural Productivity and Crop Improvement
- RNA modifications and cancer
- Bacteriophages and microbial interactions
- Aquaculture disease management and microbiota
- Health Systems, Economic Evaluations, Quality of Life
Vrije Universiteit Brussel
2012-2023
VIB-VUB Center for Structural Biology
2012-2023
Vlaams Instituut voor Biotechnologie
2023
Utrecht University
2015-2020
University Medical Center Utrecht
2019-2020
University of Glasgow
2019
KU Leuven
2009-2014
Russian Academy of Sciences
2003
Recent genome-wide association studies identified single nucleotide polymorphisms (SNPs) on the chromosome 9p21.3 conferring risk for CAD (coronary artery disease) in individuals of Caucasian ancestry. We performed a genetic study to investigate effect 12 candidate SNPs within locus Saudi population Eastern Province Arabia. A total 250 patients who had experienced an myocardial infarction (MI) and 252 age-matched healthy controls were genotyped using TaqMan assay. Controls with evidenced...
The aim of the present study was to describe occurrence and determinants angiotensin-converting enzyme (ACE) inhibitor (ACEI) intolerance angioedema (AE) among patients initiating ACEI therapy in a real-world primary care population.Two nested case-control studies were conducted cohort 276 977 aged ≥45 years ACEIs from 2007 2014 UK Clinical Practice Research Datalink (CPRD). Cases AE occurring for first time during (n = 416) matched with AE-free controls 4335) on duration treatment....
Background— Studies of recurrent or subsequent disease events may be susceptible to bias caused by selection subjects who both experience and survive the primary indexing event. Currently, magnitude any bias, particularly for time-to-event analysis in genetic association studies, is unknown. Methods Results— We used empirically inspired simulation studies explore impact on marginal hazard ratio risk among those with established coronary heart disease. The extent was determined magnitudes...
Abstract Angioedema in the mouth or upper airways is a feared adverse reaction to angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blocker (ARB) treatment, which used for hypertension, heart failure diabetes complications. This candidate gene genome-wide association study aimed identify genetic variants predisposing angioedema induced by these drugs. The discovery cohort consisted of 173 cases 4890 controls recruited Sweden. In analysis, ETV6, BDKRB2, MME , PRKCQ were...
Angioedema occurring in the head and neck region is a rare sometimes life‐threatening adverse reaction to angiotensin‐converting enzyme inhibitors (ACEIs) angiotensin receptor blockers (ARBs). Few studies have investigated association of common variants with this extreme reaction, but none explored combined influence yet. Adjudicated cases ACEI‐induced angioedema (ACEI‐AE) or ARB‐induced (ARB‐AE) controls were recruited at five different centers. Sequencing 1,066 samples (408 ACEI‐AE,...
Small heat-shock proteins (sHsps) are ubiquitous molecular chaperones. sHsps function as homooligomers or heterooligomers that prone to subunit exchange and structural plasticity. Here, a procedure for obtaining diffraction-quality crystals of the α-crystallin domain human Hsp27 is presented. Initially, limited proteolysis was used delineate corresponding stable fragment (residues 90–171). This could be crystallized, but examination using X-rays indicated partial disorder. The...
To assess the required characteristics (cost, sensitivity and specificity) of a pharmacogenomic test for being cost-effective prevention angiotensin-converting enzyme inhibitors induced angioedema. Furthermore, we assessed influence only testing high-risk populations.A decision tree was used.With willingness-to-pay threshold €20,000 €80,000 per quality adjusted life year, 100% sensitive specific may have maximum cost €1.30 €1.95, respectively. When genotyping populations, price would be...
Mycoredoxins (Mrxs) are a group of small dithiol oxidoreductases that share conserved CXXC active site sequence motif resembling glutaredoxins. They commonly found in saprophytic microorganisms, including Actinobacteria such as Mycobacterium tuberculosis. Among the known mycoredoxins, Corynebacterium glutamicum (Cg) Mrx1, featuring CVQC site, functions mycothiol-dependent monothiol oxidoreductase. On other hand, Mrx2, also NrdH-redoxin and containing same motif, exhibits oxidoreductase...