A5004185666- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Agricultural and Food Sciences
- Insect symbiosis and bacterial influences
- Fish biology, ecology, and behavior
- Cassava research and cyanide
- Insect and Pesticide Research
Fundação de Medicina Tropical
2020-2023
Universidade do Estado do Amazonas
2020-2023
Abstract Objective To determine whether a combination of single intramuscular (IM) dose pentamidine (7 mg/kg) followed by oral tamoxifen 40 mg/day for 20 days is non‐inferior to three IM doses 7 mg/kg in the treatment cutaneous leishmaniasis with margin 15%. Methods Phase II, randomised, controlled, open‐label, non‐inferiority clinical trial. Primary outcome was complete healing lesions 6 months after starting treatment. Secondary outcomes were 3 and determining presence severity adverse...
Background: Chagas disease is gaining importance in the Brazilian Amazon region as a differential diagnosis of febrile syndrome. The most recent microoutbreak occurred Ipixuna, Amazonas state. Methods: An epidemiological survey was conducted using parasitological and serological tests, electrocardiographic analysis. Results: patients belonged to one family had ingested açaí acquired from Ipixuna. All reported fever initially thick blood smear test done identify Trypanosoma cruzi....
ObjectivesTo compare topical granulocyte and macrophage colony-stimulating factor (GM-CSF) miltefosine (G + M) versus placebo (P or parenteral meglumine antimoniate (MA) in the treatment of 150 patients with cutaneous leishmaniasis (CL) caused by Leishmania guyanensis Amazon.DesignA randomized double-blinded clinical trial.ResultsAt 90 days after initiation therapy, cure rates were 66%, 58%, 52% for groups P M, G MA, respectively (p > 0.05). Cure at 180 did not differ. Healing time was...