A5011149196- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Cardiomyopathy and Myosin Studies
- Insect symbiosis and bacterial influences
- Metabolism and Genetic Disorders
- Healthcare during COVID-19 Pandemic
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Biochemical and Molecular Research
- Viral Infections and Immunology Research
- Liver Disease and Transplantation
- Biosimilars and Bioanalytical Methods
- COVID-19 epidemiological studies
- Monoclonal and Polyclonal Antibodies Research
- Linguistics and Education Research
- Cardiovascular Function and Risk Factors
- Cell death mechanisms and regulation
- Growth Hormone and Insulin-like Growth Factors
- Adrenal Hormones and Disorders
- Behavioral and Psychological Studies
- Indigenous Health and Education
- Chemotherapy-induced cardiotoxicity and mitigation
- Drug-Induced Adverse Reactions
- Maternal and Neonatal Healthcare
- Abdominal vascular conditions and treatments
Fundação de Medicina Tropical
2018-2025
Universidade do Estado do Amazonas
2018-2024
Universidade Federal do Amazonas
2021-2024
Universidade Nilton Lins
2021-2022
Instituto de Medicina Tropical
2021
Fundação Oswaldo Cruz
2021
Amazon (Germany)
2021
Instituto de Salud Carlos III
2009-2019
Universitat Autònoma de Barcelona
2019
Centro de Investigación Biomédica en Red
2012-2019
In the Brazilian Amazon, suspected source of infection in an outbreak acute Chagas disease involving 10 patients was Euterpe oleracea (açaí berry) juice. Patient blood and juice samples contained Trypanosoma cruzi TcIV, indicating oral transmission agent.
The prevalence and characteristics of chronic Chagas disease (CCD) in the Amazon Region remain underexplored. This study aimed to describe challenges encountered during a serological survey follow-up CCD, while also highlighting potential risk factors Region. involved residents periurban rural areas Manaus Brazilian Amazon. All participants were invited complete clinical, epidemiological, demographic questionnaire provide blood sample for anti- Trypanosoma cruzi ( T. ) IgG tests. A total...
Background: In the past two decades, a new epidemiological profile of Chagas' disease (CD) has been registered in Brazilian Amazon where oral transmission indicated as responsible for increase acute cases. Amazonas state, five outbreaks CD have since 2004. The cardiac manifestations these cases may be characterized by diffuse myocarditis, with alteration electrocardiogram (ECG) and transthoracic echocardiogram (TTE). Objective: To perform evaluation autochthonous patients phase at least one...
The city of Manaus, Brazil, has seen two collapses the health system due to COVID-19 pandemic. We report anti-SARS-CoV-2 nucleocapsid IgG antibody seroconversion rates and associated risk factors in Manaus residents before second wave epidemic Brazil.A convenience sample adult (aged ≥18 years) was recruited through online university website advertising into DETECTCoV-19 study cohort. current analysis included a subgroup participants who had at least serum collections separated by 4 weeks...
Abstract Objective To describe clinical, epidemiological and management information on cases of acute Chagas disease (ACD) by oral transmission in the state Amazonas western Amazon. Methods Manual electronic medical records patients diagnosed with ACD at Fundação de Medicina Tropical Doutor Heitor Vieira Dourado (FMT‐HVD) were included. Results There 147 CD registered from 10 outbreaks that occurred between 2004 2022. The pathway was through route, probable contaminated palm fruit juice...
Abstract In the Amazon region, Trypanosoma cruzi transmission cycles involve a great diversity of Triatominae vectors and mammal reservoirs. Some Rhodnius spp. mainly inhabit palm trees that act as microhabitats for hosts vectors. The current study aimed to describe aspects bio‐ecology reservoirs T. in relation human populations resident near areas with large quantities trees, rural, peri‐urban urban collection environments, located Western Brazilian Amazon. pictipes Didelphis marsupialis...
Background: Chagas disease is gaining importance in the Brazilian Amazon region as a differential diagnosis of febrile syndrome. The most recent microoutbreak occurred Ipixuna, Amazonas state. Methods: An epidemiological survey was conducted using parasitological and serological tests, electrocardiographic analysis. Results: patients belonged to one family had ingested açaí acquired from Ipixuna. All reported fever initially thick blood smear test done identify Trypanosoma cruzi....
This study describes a cblE type of homocystinuria associated with haemolytic-uremic syndrome (HUS) features. We report on male infant aged 43 days presenting failure to thrive, hypotonia, pancytopaenia, HUS symptoms (microangiopathic haemolytic anaemia and thrombocytopaenia signs renal involvement) fatal evolution. An underlying cobalamin disorder was diagnosed after bone marrow examination revealed megaloblastic changes hyperhomocysteinaemia. urinary organic acid analysis normal...
ObjectivesTo compare topical granulocyte and macrophage colony-stimulating factor (GM-CSF) miltefosine (G + M) versus placebo (P or parenteral meglumine antimoniate (MA) in the treatment of 150 patients with cutaneous leishmaniasis (CL) caused by Leishmania guyanensis Amazon.DesignA randomized double-blinded clinical trial.ResultsAt 90 days after initiation therapy, cure rates were 66%, 58%, 52% for groups P M, G MA, respectively (p > 0.05). Cure at 180 did not differ. Healing time was...
El objetivo del trabajo fue verificar la existencia de variaciones morfométricas Trypanosoma evansi en Hydrochaeris hydrochaeris criados cautiverio Chaco, Argentina. Para ello se efectuaron mediciones variables biométricas 52 ejemplares T. provenientes carpinchos. Se reconocieron dos parásito, delgadas y rechonchas. Las dimensiones ambas formas compararon con los resultados obtenidos carpinchos amazonas peruano. Los revelaron diferencias significativas todas las sometidas a estudio...
Background Chagas disease is a neglected tropical that still considered global health emergency. In the Amazon region, most of reports are acute cases associated with oral transmission. This study aimed to evaluate myocardial injury in patients before and after treatment. Methods Results We evaluated 23 3 different stages progression. Group 1 had 12 during phase, at time diagnosis, year treatment, 2 11 late postacute phase who were 5.2 years on average diagnosis ECGs Selvester score, 24-hour...
Chris Macaraeg has been a lead scientist for method development, validation, and study support intended regulated pre-clinical/clinical studies within the Pharmacokinetics Drug Metabolism department at Amgen Inc, Thousand Oaks, CA. He joined in 2006. His expertise also includes automation transfer to CROs. received his BS degree Physiological Science Neuroscience from University of California, Los Angeles, CA MS Forensic Pace University, New York, NY. Stability therapeutic proteins...
Abstract Background In the Brazilian Amazon, a new epidemiological profile of Chagas disease transmission, oral route, has been detected and cited as being responsible for increase in acute cases Brazil. The clinical evaluation (ACD) challenge since it can progress to chronic phase with cardiac alterations, follow-up by modern diagnostic methods is very difficult due socio-geographical characteristics Amazon. Thus, alternatives should be sought alleviate this problem. We conducted study...
Introduction: Pharmacological adherence is a key factor in managing chronic non-communicable diseases (NCDs), so its efficacy concerning new therapies emerges as an essential consideration. Despite efforts, rates vary widely, highlighting the complexity of problem. Non-adherence affects treatment effectiveness and increases patient burden medical costs. Understanding interplay between burden, morbidity, crucial for adapting health strategies. Objective: This study aims to measure...
As alterações cognitivas são comuns ao longo da idade avançada. Identificar o limite tênue entre declínio e comprometimento cognitivo (CC) é um grande desafio. A presença de preditores cognitivos poderá nos auxiliar na identificação, por teste rastreio específico, idosos com cognitivo, atendidos no serviço geriatria do Hospital Universitário Universidade Federal Maranhão, que objetivo deste estudo. Trata-se estudo transversal, descritivo quantitativo através revisão 251 prontuários coleta...
Foi realizada uma análise entre 2021 e 2024 do perfil dos autores das publicações da Brazilian Medical Students Journal por meio de um estudo tipo descritivo retrospectivo bibliométrico com abordagem quantitativa. No período analisado, observou-se oscilações no número submissões, mas diminuição constante na taxa aceite, refletindo esforço editorial para elevar a qualidade periódico. A maioria artigos publicados veio regiões Nordeste, Sul Sudeste. filiação é predominantemente instituições...
Objectives This study aims to provide a comprehensive analysis of clinical and epidemiological data related Chronic Chagas Cardiomyopathy (CCC) in the Amazon region Brazil. Methods A review observational, retrospective, cross-sectional studies Disease Brazil was conducted, case series addressing CCC patients treated at FMT-HVD outpatient clinic, reference center for disease Brazil, carried out. Results Clinical characteristics 55 from with were described. The most common electrocardiographic...
A trombose venosa é caracterizada pelo acúmulo excessivo de estruturas compostas por fibrinas e plaquetas no interior veias, ocasionando obstrução parcial ou oclusão, afetando geralmente os membros inferiores. Destacam-se como principais fatores risco a estase sanguínea, lesão endotelial estados hipercoagulabilidade, intensificando-se com o avançar da idade. Correlacionar desenvolvimento em pacientes sadios que foram acometidos COVID-19. busca artigos científicos foi realizada nas bases...
Chagas disease (CD), with approximately 10,000 deaths annually, has become a worldwide health problem. Approximately 35% of cases may show cardiac manifestations such as arrhythmias and/or conduction disorders, heart failure, thromboembolic accidents, and sudden death. The Amazon region long been considered non-endemic area for CD; however, in the last decades, an increase number acute chronic cases, evolution received greater attention. Here, we report successful implementation...
A OMS (Organização Mundial de Saúde) classifica a ansiedade como: transtorno generalizada, do pânico, fobias sociais ou específicas e social (SAD). Todos os tipos compartilham sintomas comuns, incluindo sentimentos mal-estar, pânico medo, problemas sono, não ser capaz ficar calmo, estar com frio / suando, falta ar, palpitações cardíacas, boca seca, náusea, prevenção situações, estes transtornos acabam prejudicando qualidade vida muitas pessoas levando muita das vezes cometer suicídios. O...
Tendo em vista os relatos sobre o uso de informações genéticas germinativas na forma preventiva e no tratar desse tipo carcinoma, bem como seu potencial padrões marcadores genéticos análogos aos perfis expressão obtidos a partir do tecido tumoral, permitindo uma previsão mais poderosa quem responderá melhor um tratamento ou regime específico. Com isso, este estudo tem objetivo avaliar importância da farmacogenética câncer mama. Trata-se revisão literatura, onde foram utilizadas as bases...
Abstract We report anti-SARS-CoV-2 nucleocapsid IgG seroconversion rates from a population-based cohort in Manaus, between August and November 2020, before the COVID-19 second wave Brazil. Among seronegative uninfected participants, we observed an overall incidence of 13.06% (95%CI, 11.52-14.79) 6.78% 5.61-8.10) for symptomatic seroconversion. Risk factors were: having case household, not wearing mask during contact, relaxation protective measures, non-remote work. intense infection...