A5065528404- Conducting polymers and applications
- Analytical Chemistry and Sensors
- Advanced Sensor and Energy Harvesting Materials
- Organic Electronics and Photovoltaics
- Electrochemical sensors and biosensors
- Advanced Memory and Neural Computing
- Extracellular vesicles in disease
- Nanoplatforms for cancer theranostics
- Pluripotent Stem Cells Research
- Fuel Cells and Related Materials
- Advanced biosensing and bioanalysis techniques
- Synthesis and properties of polymers
- MXene and MAX Phase Materials
- Neuroscience and Neural Engineering
- Advancements in Semiconductor Devices and Circuit Design
- Tissue Engineering and Regenerative Medicine
- Microfluidic and Capillary Electrophoresis Applications
- Various Chemistry Research Topics
- Thin-Film Transistor Technologies
- Advanced Chemical Sensor Technologies
- 3D Printing in Biomedical Research
- Photopolymerization techniques and applications
- Advanced Biosensing Techniques and Applications
- Nanopore and Nanochannel Transport Studies
- Thermal properties of materials
King Abdullah University of Science and Technology
2019-2024
University of Cambridge
2019
Vidyasirimedhi Institute of Science and Technology
2018
Abstract Organic electrochemical transistors (OECTs) are the building blocks of biosensors, neuromorphic devices, and complementary circuits. One rule in materials design for OECTs is inclusion a hydrophilic component chemical structure to enable ion transport film. Here, it shown that ladder‐type, side‐chain free polymer poly(benzimidazobenzophenanthroline) (BBL) performs significantly better than donor–acceptor type copolymer bearing ethylene glycol side chains (P‐90). A combination...
Abstract Conjugated polymer films, which can conduct both ionic and electronic charges, are central to building soft sensors actuators. Despite the possible interplay between light absorption mixed conductivity of these materials in aqueous biological media, no single film has been utilized create a solar-switchable organic bioelectronic circuit that relies on fully reversible redox reaction-free potentiometric photodetection current modulation. Here we demonstrate by an electron...
An n-type organic photoelectrochemical transistor produces large and reversible current changes in response to light-intensity variations aqueous electrolytes. A long exciton lifetime of the gate ensures a high photovoltage response.
The tight regulation of the glucose concentration in body is crucial for balanced physiological function. We developed an electrochemical transistor comprising n-type conjugated polymer film contact with a catalytic enzyme sensitive and selective detection bodily fluids. Despite promise these sensors, property that led to such high performance has remained unknown, charge transport being only characteristic under focus. Here, we studied impact chemical structure on surface properties...
Abstract Introducing ethylene glycol (EG) side chains to a conjugated polymer backbone is well‐established synthetic strategy for designing organic mixed ion‐electron conductors (OMIECs). However, the impact that film swelling has on conduction properties yet be scoped, particularly electron‐transporting ( n ‐type) OMIECs. Here, authors investigate effect of length branched EG charge transport ‐type OMIECs based naphthalene‐1,4,5,8‐tetracarboxylic‐diimide‐bithiophene backbone. Atomic force...
Poly(3,4-ethylenedioxythiophene) (PEDOT) doped with poly(styrene sulfonate) (PSS) is the most commonly used conducting polymer in organic bioelectronics. However, electrochemical capacitances exceeding current state-of-the-art are required for enhanced transduction and stimulation of biological signals. The long-term stability films during device operation storage aqueous environments remains a challenge routine applications. In this work, we electrochemically synthesize PEDOT composite...
Abstract Among the existing two-dimensional materials, MXenes, i.e. transition metal carbides, nitrides and/or carbonitrides, stand out for their excellent electrochemical properties. Due to high charge storage capacity, metal-like conductivity, biocompatibility as well hydrophilicity, Ti 3 C 2 T x MXene-based inks hold great potential scalable production of skin conformable electronics via direct printing methods. Herein, we develop an aqueous MXene ink and inkjet-print films on...
Abstract The integration of n‐type (electron‐transporting) polymers with oxidase enzymes has allowed building high‐performance organic electrochemical transistor (OECT) based metabolite sensors. Yet, the operation mechanism these devices is poorly understood. Here, process investigated for conversion oxidation to electrical current in an (n‐OECT). By monitoring oxygen (O 2 ), hydrogen peroxide, and pH changes electrolyte as well potential each contact n‐OECT during glucose detection, light...
The last decade has witnessed rapid progress in the development of implantable and wearable bio(chemical) sensors, which allow for real-time, continuous health monitoring. Among different device configurations, organic electrochemical transistors (OECTs) have shown great potential transducing weak biological signals with on-site amplification as components complex circuits low power requirements. Yet, a significant technological challenge remains way these devices are integrated sources that...
Tumor-derived extracellular vesicles (TEVs) induce the epithelial-to-mesenchymal transition (EMT) in nonmalignant cells to promote invasion and cancer metastasis, representing a novel therapeutic target field severely lacking efficacious antimetastasis treatments. However, scalable technologies that allow continuous, multiparametric monitoring for identifying metastasis inhibitors are absent. Here, development of functional phenotypic screening platform based on organic electrochemical...
We introduce here hemiaminal ether linkages, synthesized by coupling a vinyl and 1,2,3-triazole, as responsive groups in polymers to allow the selective release of functional molecule. The kinetics benzotriazole from polymer nanoparticles shows fast at low pH values prolonged or even no under mildly acidic conditions neutral pH.
Abstract Organic electrochemical transistors (OECTs) excel at biosensing due to their high amplification factor, which allows for detecting low analyte concentrations and picking up weak physiological signals. One prominent use of OECT is in enzymatic metabolite sensing, with the claimed have a superior limit detection enhanced sensitivity compared conventional two or three electrode‐based setups. However, there has yet be direct comparative study on performance metrics these sensor...
The development of electronics adept at interfacing with the nervous system is an ever-growing effort, leading to discoveries in fundamental neuroscience applied clinical setting. Highly capacitive and electrochemically stable electronic materials are paramount for these advances. A systematic study presented where copolymers based on 3,4-ethylenedioxythiophene (EDOT) its hydroxyl-terminated counterpart (EDOTOH) electropolymerized aqueous solution presence various counter anions additives....
Electronic immunosensors are indispensable tools for diagnostics, particularly in scenarios demanding immediate results. Conventionally, these sensors rely on the chemical immobilization of antibodies onto electrodes. However, globular proteins tend to adsorb and unfold surfaces. Therefore, self-assembled monolayers (SAMs) thiolated alkyl molecules commonly used indirect gold-antibody coupling. Here, a limitation associated with SAMs is revealed, wherein they curtail longevity protein...
Stem cell osteogenic differentiation is a complex process, associated with number of events such as the secretion collagen type I, osteopontin, osteonectin, osteocalcin and Bone Morphogenic Protein 2 (BMP-2). These molecules can be used markers to monitor stem fate while studying effects specific treatment (e.g. electrical stimulation). Currently available techniques, evaluation expression levels genes end-point biochemical assays, do not allow real-time monitoring cellular processes,...
Cancer-derived exosomes (cEXOs) facilitate transfer of information between tumor and human primary stromal cells, favoring cancer progression. Although the mechanisms used during this exchange are still not completely understood, it is known that binding initial contact established cEXOs cells. Hence, studying finding strategies to block great therapeutic value. However, such studies challenging for a variety reasons, including need cell culture, difficulty in decoupling isolating from...
Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) are a promising cell source for cardiac regenerative medicine and in vitro modeling. However, hPSC-CMs exhibit immature structural functional properties compared with adult cardiomyocytes. Various electrical, mechanical, biochemical cues have been applied to enhance hPSC-CM maturation but limited success. In this work, we investigated the potential application of semiconducting polymer...
Electron transporting (n-type) polymeric mixed conductors are an exciting class of materials for devices with aqueous electrolyte interfaces, such as bioelectronic sensors, actuators, and soft charge storage systems. However, their transport performance falls short p-type counterparts, primarily due to electrochemical side reactions the oxygen reduction reaction (ORR). To mitigate ORR, a common strategy in n-type organic semiconductor design focuses on lowering lowest unoccupied molecular...
N-type organic mixed ionic electronic conductors (n-OMIECs) struggle to match the performance of p-type counterparts, particularly in bioelectronics' flagship device, electrochemical transistor. Enhancing n-type transistor typically necessitates synthesis new materials. More sustainable post-synthetic treatments, known improve devices dry and oxygen-free conditions, are not applied n-OMIECs. This study introduces thermal annealing enhance n-OMIECs' electron mobility without sacrificing their...
Conjugated polymer films that can conduct ionic and electronic charges are central to building soft sensors actuators. Despite the possible interplay between light absorption mixed conductivity of these materials in aqueous biological media, no film has ever been used realize a solar-switchable organic bioelectronic circuit relying on fully reversible, redox reaction-free mechanism. Here we show absorbed by an electron cation-transporting reversibly modulates its electrochemical potential...