Manuel Alejandro Vargas-Vargas

ORCID: 0000-0003-3239-123X
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Research Areas
  • Adipose Tissue and Metabolism
  • Diet, Metabolism, and Disease
  • Diet and metabolism studies
  • Liver Disease Diagnosis and Treatment
  • Exercise and Physiological Responses
  • Mitochondrial Function and Pathology
  • Phytochemicals and Antioxidant Activities
  • Iron Metabolism and Disorders
  • Hemoglobinopathies and Related Disorders
  • Pharmacology and Obesity Treatment
  • Muscle metabolism and nutrition
  • Antioxidant Activity and Oxidative Stress
  • Sirtuins and Resveratrol in Medicine
  • Restless Legs Syndrome Research
  • Cardiac Ischemia and Reperfusion
  • Health and Lifestyle Studies
  • Metabolism and Genetic Disorders
  • Biochemical effects in animals
  • Alcohol Consumption and Health Effects
  • Pain Mechanisms and Treatments
  • Leaf Properties and Growth Measurement
  • Natural Products and Biological Research
  • Phytochemistry Medicinal Plant Applications
  • Psidium guajava Extracts and Applications
  • Natural Antidiabetic Agents Studies

Universidad Michoacana de San Nicolás de Hidalgo
2019-2025

10.26633/rpsp.2020.72 article EN cc-by-nc-nd Revista Panamericana de Salud Pública 2020-06-01

High fat or fructose induces non-alcoholic fatty liver disease (NAFLD) accompanied of mitochondrial dysfunction and oxidative stress. Controversy remains about whether is more deleterious for NAFLD development. To get insights this issue to determine if the severity induced by related degree dysfunction, we compared effects diets containing high (HF), (Fr) plus (HF + Fr) on development, function, ROS production lipid peroxidation.Wistar rats were assigned four groups: Control, fed with...

10.1186/s12944-019-1024-5 article EN cc-by Lipids in Health and Disease 2019-03-30

Non-alcoholic fatty liver disease (NAFLD) is characterized by lipid accumulation in hepatocytes, and advanced stages, inflammation fibrosis. Excessive ROS production due to mitochondrial dysfunction contributes NAFLD development, making the decrease an emerging target alleviate NAFLD. Previously, we have shown that avocado oil, a source of several bioactive compounds with antioxidant effects, decreases oxidative stress improving function electron transport chain (ETC) decreasing levels...

10.3389/fphar.2022.1089130 article EN cc-by Frontiers in Pharmacology 2022-12-19

High-fat and high-carbohydrate (HF-HC) diets induce metabolic syndrome via mitochondrial dysfunction oxidative stress. We have previously shown that this may be prevented by avocado oil, a source of bioactive molecules with antioxidant properties. However, it is unknown if these effects are mediated the unsaponifiable fraction oil (UFAO). Thus, we tested improves glucose metabolism, bioenergetics stress in mitochondria from kidney liver rats fed an HF-HC diet. found 12 weeks diet impaired...

10.3390/metabo14080431 article EN cc-by Metabolites 2024-08-04

Increased intramitochondrial free iron is a key feature of various liver diseases, leading to oxidative stress, mitochondrial dysfunction, and damage. Polydatin polyphenol with hepatoprotective effect, which has been attributed its ability enhance metabolism antioxidant defenses, thereby inhibiting reactive oxygen species (ROS) dependent cellular damage processes diseases. However, it not explored whether polydatin able exert effects by protecting the phospholipid cardiolipin against from...

10.3390/ijms252011104 article EN International Journal of Molecular Sciences 2024-10-16

Diabetes mellitus is a chronic degenerative disease characterized by hyperglycemia and oxidative stress. Iron catalyzes free radical overproduction. High iron concentrations have previously been reported to promote an increase in stress; however, the effect of restriction diabetes has not yet explored, so we tested see if diabetic rats reduces damage improved muscle function. Wistar were assigned 4 groups: Control; Diabetic; Diabetic with high diet, dietary restriction. After 8 weeks...

10.3390/antiox11040731 article EN cc-by Antioxidants 2022-04-07

Obesity is a chronic disease that impairs skeletal muscle function, affects the ability to contract, and promotes development of fatigue. For this reason, study treatments seek reduce harmful effects obesity on tissue has been deepened. Diazoxide treatment various exercise protocols have proposed protect against oxidative stress its effects. However, intensity duration combined with diazoxide would obtain best results for improving function in obese rats unknown. To end, evaluated three...

10.3390/biology11091367 article EN cc-by Biology 2022-09-17

Los efectos indeseables y el alto costo de los tratamientos farmacológicos contra la diabetes han ocasionado un aumento en interés por uso plantas medicinales para tratar esta enfermedad. Existe alrededor del mundo una variedad que se utilizado manera empírica tratamiento diabetes. En algunos casos, ha estudiado sistemática composición estas plantas, sus mecanismos acción, siendo ejemplo mejor conocido lila francesa, planta contiene metformina, fármaco antidiabético más usado mundo. Sin...

10.35830/mcya.vi24.533 article ES Milenaria Ciencia y arte 2024-12-10

En un mundo donde las enfermedades crónicas como la diabetes, hipertensión y el hígado graso son cada vez más comunes, importancia de una alimentación balanceada se vuelve esencial. Aunque parezca sencillo, llevar dieta equilibrada es desafío diario, complicado por falta tiempo desinformación general sobre los alimentos benéficos para nuestra salud. Aquí entra en juego superalimento poco reconocido: aceite aguacate. Este verdadero “oro verde” ha capturado atención comunidad científica debido...

10.35830/mcya.vi23.454 article ES Milenaria Ciencia y arte 2024-06-27

Currently, the incidence of diabetes mellitus (DM) in world population has obtained epidemic proportions, becoming one leading causes death. One main complications this disease are ulcers caused by neuropathy and diabetic vasculopathy. Diabetic can be prevented with proper follow‐up. However, pharmacological treatments for such pathology usually expensive, lengthy, inefficient. Ethereal oils or essential a complex mixture, mainly secondary metabolites lipophilic highly volatile plants, they...

10.1096/fasebj.2020.34.s1.06404 article EN The FASEB Journal 2020-04-01

Exercise has been implemented as an efficient method to maintain optimal state of health, also, used a non‐pharmacological complementary treatment in numerous pathologies. It documented that the application exercise protocols improves muscle functioning, prevents lipids accumulation and cell damage, well delay onset fatigue. The objective this work was evaluate effect three different intensities exercise, low, medium, high, on development strength, fatigue resistance, lipid profile rats...

10.1096/fasebj.2020.34.s1.06203 article EN The FASEB Journal 2020-04-01
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