A5074844674- Peptidase Inhibition and Analysis
- Protein Degradation and Inhibitors
- Cancer Research and Treatments
- Cancer, Lipids, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Cancer Mechanisms and Therapy
- Cancer, Hypoxia, and Metabolism
- Liver Disease Diagnosis and Treatment
- Virus-based gene therapy research
- Signaling Pathways in Disease
- Histone Deacetylase Inhibitors Research
- HER2/EGFR in Cancer Research
- Click Chemistry and Applications
- Polyamine Metabolism and Applications
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- ATP Synthase and ATPases Research
- Mechanisms of cancer metastasis
- Monoclonal and Polyclonal Antibodies Research
- Isotope Analysis in Ecology
- Cellular transport and secretion
- Cassava research and cyanide
- Autophagy in Disease and Therapy
The University of Texas Health Science Center at San Antonio
2024-2025
Washington University in St. Louis
2021-2024
The University of Texas at San Antonio
2024
University of Nevada, Las Vegas
2018-2021
<p>Figure S1. Levels of PELP1 expression in 6 HCC cell lines.</p>
<p>Figure S2. SMIP34 treatment downregulates liver specific genes, MYC and E2F pathway targeted genes in HCC cells.</p>
Abstract Background: Hepatocellular carcinoma (HCC) accounts for more than 90% of instances liver cancer, which ranks as the fifth most frequent cancer in United States. Furthermore, Texas leads nation age-adjusted incidence HCC. Most patients are diagnosed with advanced, unresectable HCC, and their 5-year survival rate is less 5% when using current systemic treatments. Therefore, there an immediate unmet need new treatment approaches Recently, unfolded protein response (UPR) endoplasmic...
Ovarian cancer (OCa) is the most lethal form of gynecologic cancer, and tumor heterogeneities at molecular, cellular, tissue levels fuel resistance to standard therapies pose a substantial clinical challenge. Here, we tested hypothesis that heightened basal endoplasmic reticulum stress (ERS) observed in OCa represents an exploitable vulnerability may overcome heterogeneity. Our recent studies identified LIPA as novel target induce ERS cells using small molecule ERX-41. However, role...
Abstract Purpose: Many cancers lack argininosuccinate synthetase 1 (ASS1), the rate-limiting enzyme of arginine biosynthesis. This deficiency causes auxotrophy, targetable by extracellular arginine-degrading enzymes such as ADI-PEG20. Long-term tumor resistance has thus far been attributed solely to ASS1 reexpression. study examines role silencing on growth and initiation identifies a noncanonical mechanism resistance, aiming improve clinical responses Experimental Design: Tumor rates were...
Abstract Hepatocellular carcinoma (HCC) is one of the leading causes cancer-related deaths in United States, with a median survival period approximately 10 months. There an urgent need for development effective targeted therapies treatment HCC. Proline-, glutamic acid- and leucine-rich protein 1 (PELP1) signaling implicated progression many cancers, although its specific contribution to HCC not yet well understood. Analysis TCGA gene expression data sets immunohistochemistry analysis tissue...
Abstract Background Many cancers silence the metabolic enzyme argininosuccinate synthetase 1 (ASS1), rate-limiting for arginine biosynthesis within urea cycle. Consequently, ASS1-negative cells are susceptible to depletion of extracellular by PEGylated deiminase (ADI-PEG20), an agent currently being developed in clinical trials. As primary mechanism resistance is re-expression ASS1, we sought a tool understand temporal emergence phenotype at single-cell level. Methods A real-time,...
This study was conducted to detect the presence of cyanide in popular fruit and vegetable smoothies juices marketed as raw natural.
Abstract Background: Hepatocellular carcinoma (HCC) is the fastest-rising cause of cancer-related mortality in United States. Furthermore, advanced HCC has a very poor prognosis, with median survival time only about ten months. Effective new targeted therapies are urgently needed for treatment HCC. Proline, glutamic acid-, and leucine-rich protein 1 (PELP1) protooncogene. PELP1 signaling been implicated development several cancers, however, its role progression remains unclear. The goal this...
<p>Supplemental Figure 6. RNA sequencing of tumors.</p>
<p>Supplemental Figure 7. Gemcitabine and docetaxel increase toxicity to ASS1 KO tumor cells treated with ADI-PEG20 either chloroquine or imipramine.</p>
<p>Supplemental Figure 5. Evidence against other possible growth support mechanisms and MEF toxicity.</p>
<p>Supplemental Figure 3. Fibroblasts support growth of Ass1 WT murine and human sarcoma cell lines.</p>
<p>Supplemental Figure 1. In vivo imaging.</p>
<p>Supplemental Figure 5. Evidence against other possible growth support mechanisms and MEF toxicity.</p>
<p>Supplemental Figure 1. In vivo imaging.</p>
<p>Supplemental Figure 4. Validation of gene knockouts and ASS1 expression in MEFs.</p>
<p>Supplemental Figure 6. RNA sequencing of tumors.</p>
<p>Supplemental Figure 3. Fibroblasts support growth of Ass1 WT murine and human sarcoma cell lines.</p>
<p>Supplemental Figure 7. Gemcitabine and docetaxel increase toxicity to ASS1 KO tumor cells treated with ADI-PEG20 either chloroquine or imipramine.</p>
<div>Abstract<p>Purpose: Many cancers lack argininosuccinate synthetase 1 (ASS1), the rate limiting enzyme of arginine biosynthesis. This deficiency causes auxotrophy, targetable by extracellular arginine-degrading enzymes such as ADI-PEG20. Long-term tumor resistance has thus far been attributed solely to ASS1 re-expression. study examines role silencing on growth and initiation identifies a noncanonical mechanism resistance, aiming improve clinical responses Experimental...
<p>Supplemental Figure 2. ASS1 expression in spontaneous murine sarcoma cell lines and growth of Ass1 KO tumors vivo.</p>