A5101537581- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Neonatal Respiratory Health Research
- Advanced X-ray and CT Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- Meningioma and schwannoma management
- COVID-19 diagnosis using AI
- Esophageal Cancer Research and Treatment
- Vascular Malformations Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Pleural and Pulmonary Diseases
- Neural dynamics and brain function
- Pain Mechanisms and Treatments
- Myasthenia Gravis and Thymoma
- Cancer Genomics and Diagnostics
- Artificial Intelligence in Healthcare and Education
- Esophageal and GI Pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- stochastic dynamics and bifurcation
- Peptidase Inhibition and Analysis
- Fungal Biology and Applications
- Renal cell carcinoma treatment
- Respiratory viral infections research
- Colorectal Cancer Treatments and Studies
National Cheng Kung University
2007-2025
National Cheng Kung University Hospital
2016-2024
China Medical University Hospital
2024
Chung Yuan Christian University
2019-2024
China Medical University
2019-2024
Mackay Memorial Hospital
2011-2023
Mackay Medical College
2019-2023
National Tsing Hua University
2011-2022
National Taipei University
2022
National Chung Hsing University
2022
ABSTRACT Neuraminidase (NA), an influenza virus envelope glycoprotein, removes sialic acid from receptors for release infected cells. For this study, we used a baculovirus-insect cell expression system to construct and purify recombinant NA (rNA) proteins of H5N1 (A/Vietnam/1203/2004) pandemic H1N1 (pH1N1) (A/Texas/05/2009) viruses. BALB/c mice immunized with these had high titers NA-specific IgG NA-inhibiting (NI) antibodies against H5N1, pH1N1, H3N2, H7N9 rNA immunization resulted in...
Abstract Objectives The study aimed to develop a combined model that integrates deep learning (DL), radiomics, and clinical data classify lung nodules into benign or malignant categories, further different pathological subtypes Lung Imaging Reporting Data System (Lung-RADS) scores. Materials methods proposed was trained, validated, tested using three datasets: one public dataset, the Nodule Analysis 2016 (LUNA16) Grand challenge dataset ( n = 1004), two private datasets, Received Operation...
Administration of a single broadly neutralizing human immunodeficiency virus (HIV)–specific antibody to HIV-infected persons leads the development antibody-resistant in absence antiretroviral therapy (ART). It is possible that monotherapy with UB-421, an blocks virus-binding site on CD4+ T cells, could induce sustained virologic suppression without induction resistance after analytic treatment interruption.
Currently, no standard of care or therapies have been established for patients with advanced HCC. We evaluated the efficacy and safety conventional transarterial chemoembolization using gelatin sponges microspheres plus lipiodol-doxorubicin (cTACE) TACE doxorubicin-loaded drug eluting beads (DEB-TACE).This retrospective study included 273 who received cTACE (n = 201) DEB-TACE. Tumor response, survival, adverse events were over a 5-year follow-up period.During follow-up, greater percentage...
Background: Preoperative localization for small invisible and impalpable pulmonary nodules is important in single-port video-assisted thoracoscopic surgery (VATS). Localization of multiple during VATS resection remains challenging. The aim our study to elucidate the efficacy preoperative CT-guided methylene blue both single nodules. Methods: Consecutive patients undergoing dye lung nodules, followed by resection, were retrospectively analyzed between January 2014 November 2019. Chi-square...
Abstract Background Low-dose computed tomography (LDCT) has been shown useful in early lung cancer detection. This study aimed to develop a novel deep learning model for detecting pulmonary nodules on chest LDCT images. Methods In this secondary analysis, three nodule datasets, including Lung Nodule Analysis 2016 (LUNA16), Received Operation (LNOP), and Health Examination (LNHE), were used train test models. The 3D region proposal network (RPN) was modified via series of pruning experiments...
Neurodevelopmental outcome in preterm infants has been of great importance recent decades. We determined the prevalence abnormal neurodevelopmental outcomes and associated risk factors very-low-birth-weight (VLBW) at 2 5 years age.We conducted a population-based, prospective cohort study VLBW born between 2002 2009 Taiwan. Sociodemographic, neonatal data, neurological assessments age were obtained from database Taiwan Premature Infant Follow-up Network.Of 6549 included study, 5407 (82.56%)...
To compare the diagnostic performance of radiomic analysis with machine learning (ML) model a convolutional neural network (CNN) in differentiating thymic epithelial tumors (TETs) from other prevascular mediastinal (PMTs). A retrospective study was performed patients PMTs and undergoing surgical resection or biopsy National Cheng Kung University Hospital, Tainan, Taiwan, E-Da Kaohsiung, Kaohsiung Veterans General Taiwan between January 2010 December 2019. Clinical data including age, sex,...
Dihydrofolate reductase (DHFR) catalyzes folic acid reduction and recycles dihydrofolate generated during dTMP biosynthesis to tetrahydrofolate. DHFR is the main target of methotrexate, most widely used agent for antifolate therapy. Nevertheless, emergence methotrexate-resistance has greatly impeded curative potential this drug. Therefore, drugs with improved efficacy are still in demand, as well an efficient vitro assay system animal model drug discovery. The aim study evaluate suitability...
Background The impact of small-for-gestational-age (SGA) on very-low-birth-weight (VLBW) premature infants remains inconclusive. This study aimed to assess the effects being born SGA status short-term and long-term outcomes in VLBW preterm infants. Methods We conducted a population-based, prospective cohort Taiwan between 2012 2017. Sociodemographic, neonatal, growth neurological data at 2 years corrected age were collected. A total 4243 24 through 32 completed weeks' gestation participated...
There is limited epidemiological data on the seasonality of respiratory syncytial virus (RSV) infection in subtropical climates, such as Taiwan. This study aimed to assess RSV among children ≤24 months age We also assessed factors (gestational [GA], chronologic [CA], and bronchopulmonary dysplasia [BPD]) associated with RSV-associated hospitalization preterm infants confirm appropriateness novel Taiwanese prophylactic policy.From January 2000 August 2010, 3572 aged ≤24-months were admitted...
Fine particulate matter 2.5 (PM2.5) induces free radicals and oxidative stress in animals, leading to a range of illnesses. In this study, Ganoderma Microsporum immunomodulatory (GMI) proteins were administered alleviate PM2.5-induced inflammatory responses mother rats, neurological damage their offspring. The results suggested that GMI administration decreased the risk disorders rats offspring by reducing white blood cell count, lessening memory impairment, preventing dendritic branches...
Abstract Background Recent advance in tissue characterization with parametric mapping imaging has the potential to be a novel biomarker for histopathologic correlation thymic epithelial tumors (TETs). The purpose of our study is evaluate MRI T1 calculation extracellular volume (ECV) fraction histologic tumor based on lymphocyte abundance. Methods A retrospective including 31 consecutive patients (14 men and 17 women, median age, 56 years; interquartile range, 12 years) TETs was performed....
Background: Adequate and representative tissue from lung tumor is important in the era of precision medicine. The aim this study to identify detailed procedure-related variables factors influencing diagnostic success adequacy for molecular testing CT-guided TTNB. Methods: Consecutive patients undergoing TTNB were retrospectively enrolled between January 2013 May 2020. Multivariate analysis was performed predictors accuracy testing. Logistic regression used risk complications. Results: A...
Abstract Neoadjuvant immunotherapy and chemotherapy have improved the major pathological response (MPR) in patients with early-stage operable non-small cell lung cancer (NSCLC). This study aimed to assess whether presence of targetable driver mutations affects efficacy combination chemotherapy. We enrolled NSCLC who received preoperative neoadjuvant therapy between January 1, 2017, December 30, 2020. was delivered platinum-doublet chemotherapy; moreover, pembrolizumab added at attending...
Candida albicans is a major fungal pathogen in humans. In C. albicans, secreted aspartyl protease 2 (Sap2) the most highly expressed aspartic vitro and virulence factor. Recent research links small GTPase Rhb1 to target of rapamycin (TOR) signaling response nitrogen availability. The results this study show that related cell growth through control SAP2 expression when protein source. This process involves various components TOR pathway, including Tor1 kinase its downstream effectors. not...
The association between advanced maternal age and neonatal outcomes remains controversial. This study attempted to determine the short-term long-term of very low birth weight (VLBW, <1500 g) preterm infants, born mothers (≥35 years).In this retrospective cohort study, VLBW infants were divided into group comparison group. We compared pregnancy complications, demographic factors, morbidities, neurodevelopmental using Bayley Scales Infant Development-Third Edition, at 24 months corrected 2...
Abstract Background The prognostic significance of cardiac radiation dose in esophageal cancer after definitive concurrent chemoradiotherapy (CCRT) remains largely unknown. We aimed to investigate the association between dose-volume parameters and overall survival (OS) squamous cell carcinoma (ESCC) CCRT. Methods One hundred twenty-one ESCC patients undergoing CCRT with intensity modulated radiotherapy technique 2008 2018 were reviewed. Cardiac calculated. Survival cumulative incidence...
Frequent use of antibiotics in preterm infants disturbs their gut microbial balance. In this preliminary observational study, we investigated the effect different antibiotic regimens, administered during first week life, on composition and diversity very low birth weight (VLBW) infants. We performed fecal sampling breastfed VLBW days 7, 14, 30. After excluding stool samples from who received probiotics or were beyond age 7 days, compared microbiota profiles between receiving a combination...
The study aimed to evaluate the effects of an advance care planning (ACP) program on knowledge and attitudes concerning palliative care, decisions regarding DNR orders in older residents a long-term institution.A quasi-experimental design was used. Participants were cognitively unimpaired institution Taiwan. experimental group (n = 29) received intervention including individual interview using ACP handbook patient education; whereas control 28) education only.There significant positive...