A5045392659- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Prenatal Screening and Diagnostics
- Blood groups and transfusion
- Neonatal Respiratory Health Research
- MicroRNA in disease regulation
- Maternal and fetal healthcare
- Congenital Heart Disease Studies
- Maternal and Perinatal Health Interventions
- Platelet Disorders and Treatments
- Congenital Diaphragmatic Hernia Studies
- Cardiovascular Issues in Pregnancy
- Ethics and Legal Issues in Pediatric Healthcare
- Diet and metabolism studies
- Hepatitis B Virus Studies
- Fetal and Pediatric Neurological Disorders
- Tracheal and airway disorders
- Blood disorders and treatments
- Nitric Oxide and Endothelin Effects
- Gestational Diabetes Research and Management
- Genetic Syndromes and Imprinting
- Heparin-Induced Thrombocytopenia and Thrombosis
- Ethics in Clinical Research
- Diabetes and associated disorders
- Health, Environment, Cognitive Aging
Oslo University Hospital
2014-2024
Institutt for Eksperimentell Medisinsk Forskning
2020
University of Oslo
2016-2020
Sørlandet Sykehus
2019
Smerteklinikken
2019
Sørlandet Hospital Arendal
2019
Akershus University Hospital
2010-2017
University Hospital of North Norway
2006-2014
UiT The Arctic University of Norway
2007-2014
Background The human placenta is a rapidly developing organ that undergoes structural and functional changes throughout the pregnancy. Our objectives were to investigate differences in global gene expression profile, of imprinted genes effect smoking first third trimester normal placentas. Materials Methods Placental samples collected from 21 women with uncomplicated pregnancies delivered at term 16 healthy undergoing termination pregnancy 9–12 weeks gestation. profile was evaluated by Human...
I første avsnitt skulle det stå: Etter at RHD-genotyping av fosteret (ved hjelp ikke-invasiv prenatal testing) og antenatal profylakse til rhesusnegative kvinner ble innført i Norge 2016, har antallet transfusjoner foster på
Abstract Objective To test the hypothesis that Doppler‐derived (calculated) uterine artery volume blood flow (cQ UtA ) reflects accurately measured directly (mQ in an experimental setting. Methods Five pregnant sheep were instrumented at 122–130 days of gestation under general anesthesia. After a 4‐day recovery period, maternal hemodynamics varied by administering to anesthesia noradrenaline, beta‐blocker, low oxygen gas mixture, epidural bupivacaine and ephedrine, consecutively. The central...
To investigate the obstetric and psychological characteristics of women who opt to use epidural analgesia (EDA) during labour impact participating in preparation courses on women's decisions EDA.Longitudinal cohort study.Akershus University Hospital, Norway.2596 with singleton pregnancies intended vaginal delivery.Data were collected using two self-completed questionnaires at pregnancy weeks 17 32. Fear childbirth was assessed by Wijma Delivery Expectancy Questionnaire (W-DEQ). Symptoms...
To measure oxygen uptake of term human fetuses and compare the values between those delivered vaginally following normal labor by cesarean section before onset labor.This was a prospective cross-sectional study.University teaching hospital.Twenty healthy pregnant women at (38-42 weeks) were included in this study. Among them, 10 elective had vaginal delivery.Umbilical vein volume blood flow measured <24 hours delivery. Immediately after delivery, fetal weight determined, umbilical venous...
Maternal alloimmunization against human platelet antigen (HPA)-1a has been implied to mediate both reduced birth weight and chronic placental inflammation. Fetal growth restriction is associated with different types of inflammation in the placenta, mainly histiocytic intervillositis villitis. The aim this prospective study was do a systematic examination placentas from HPA-1a alloimmunized pregnancies, focus on histopathological immunohistochemical diagnosis variants In Polish-Norwegian...
Abstract Aim The aims of this nationwide retrospective cohort study were to determine the time and causes detection severe congenital heart defects (CHDs) in live‐born infants Norway between 2017 2020. Methods Information regarding with CHDs was retrieved from national registries medical records. Results A total 219 776 born 01.01.2017 31.12.2020. Severe diagnosed 442 (0.2%) infants. Of these, 376 (85%) either prenatally ( n = 203, 46%) or before discharge hospital after birth 173, 39%). 56...
The duration of pregnancy and initiation labour are thought to be controlled by fetal, maternal placental factors. aim this study was investigate whether influences gene expression in placenta near term. Placental samples were obtained from 27 women after vaginal delivery (labouring) 17 elective Caesarean section (non-labouring). All Caucasian had uncomplicated pregnancies. For global analysis, human oligo-arrays used, representing 24 650 genes each. An empirical Bayes analysis applied order...
To investigate the difference between physiological and pathological cardiac remodelling induced, respectively, by pregnancy angiotensin (Ang) II, to test hypothesis that protects against Ang II effects.Female Wistar rats, pregnant (n = 12) non-pregnant 12), were implanted with mini-pumps containing saline (sham) or 150 ng kg(-1) min(-1) II. Ten days later echocardiography blood pressure measurement performed. Expression of 22 genes was assessed using RT-PCR. Microscopic sections LV prepared...
The prevalence of Down syndrome (DS) is approximately 1 per 1000 births and influenced by increasing maternal age over the last few decades. DS strongly associated with congenital heart defects (CHDs), especially atrioventricular septal defect (AVSD). Our objectives were to investigate live-born infants having a severe CHD in Norwegian population 20 years compare outcomes AVSD without DS.
Women's autonomy and an inclusive society for all individuals are highly valued in Norway. The Norwegian Biotechnology Act changed 2020 allowing first-trimester screening cell-free DNA common trisomies to pregnant women. However, implementing non-invasive prenatal testing (NIPT) a public antenatal care program is difficult, because many patients, politicians, medical professionals do not consider trisomy 21 severe disease. Screening at early gestation might inevitably lead increase pregnancy...
Laeverin is a placenta-specific membrane-bound aminopeptidase. In this study we wanted to: 1) serially measure plasma levels of laeverin in healthy women during the second half pregnancy and postpartum, 2) determine whether differently expressed at 22-24 weeks who later develop preeclampsia compared to controls, 3) compare protein expression placenta umbilical vein serum preeclamptic pregnancies birth.Plasma was obtained serially, approximately every 4-weeks, from 53 with uncomplicated 22+0...
Background Coronary flow reserve (CFR) is used as a measure of coronary endothelial function. We investigated the effect increased afterload on CFR pregnant and non-pregnant rats. Methods Afterload increase in Wister rats (both non-pregnant) was achieved by infusion angiotensin II (Ang II) for ∼10 days or subjecting them to transverse aortic constriction (TAC) ∼14 days. Control groups were infused with 0.9% NaCl had sham surgery, respectively. In rats, experiments performed close term...
Laeverin is a placenta-specific protein that normally expressed in the plasma membrane of human trophoblasts. In previous studies, we showed higher expression levels laeverin gene preeclamptic compared with normal placentas and found was ectopically cytoplasm placentas. Our objective to investigate combining immunohistochemistry immunofluorescence.Tissue microarray analysis 72 placentas, obtained from 33 39 uncomplicated pregnancies, performed. labeled specific antibody for...
05.10.2020: Originalartikkel - De fleste gravide kvinner i Oslo-regionen betalte selv for å få utført tidlig ultralyd eller NIPT-test hvis de ikke oppfylte kriteriene tilbud om utredning etter nasjonale retningslinjene.
Cardiopulmonary collapse during labour is a catastrophic event caused by various medical, surgical and obstetrical conditions. It an emergency that threatens the life of mother her unborn child. We present case pregnant woman who suffered from preeclampsia underwent induction labour. Severe lung edema occurred early in cardiopulmonary collapse. Advanced heart-lung resuscitation was established immediately continued until cesarean section performed few minutes later. The outcome favourable...
Fetal medicine is a subspecialty of obstetrics investigating the development, growth and disease human fetus. The advances in fetal imaging (ultrasonography, MRI) molecular diagnostic techniques, together with possibility intervention utero, make an important, rapidly developing field within women's healthcare. Therefore, variety specialists, such as neonatologists, pediatric cardiologists, medical geneticists, radiologists surgeons, are necessary to adjunct diagnosis treatment fetus...