A5069025565- Biofuel production and bioconversion
- Bacteriophages and microbial interactions
- Gut microbiota and health
- Anaerobic Digestion and Biogas Production
- Click Chemistry and Applications
- Monoclonal and Polyclonal Antibodies Research
- Zoonotic diseases and public health
- Enzyme-mediated dye degradation
- Advanced Biosensing Techniques and Applications
- Microbial Natural Products and Biosynthesis
- Microbial Community Ecology and Physiology
- Advanced biosensing and bioanalysis techniques
- Microscopic Colitis
- Inflammatory Bowel Disease
- Microbial Metabolic Engineering and Bioproduction
- Wastewater Treatment and Nitrogen Removal
- Fungal Biology and Applications
- RNA and protein synthesis mechanisms
Otto-von-Guericke University Magdeburg
2018-2025
Max Planck Institute for Dynamics of Complex Technical Systems
2019-2025
Max Planck Society
2019
One Health seeks to integrate and balance the health of humans, animals, environmental systems. These three spheres are intricately interconnected through microbiomes, which universally present exchange microbes genes, influencing not only human animal but also key environmental, agricultural, biotechnological processes. Preventing emergence pathogens as well monitoring controlling composition microbiomes microbial effectors including virulence factors, toxins, antibiotics, non-ribosomal...
Phages are viruses that infect prokaryotes and can shape microbial communities by lysis, thus offering applications in various fields. However, challenges exist sampling, isolation accurate prediction of the host specificity phages as well identification newly replicated virions response to environmental challenges.
The yield and productivity of biogas plants depend on the degradation performance their microbiomes. spatial separation anaerobic digestion (AD) process into a separate hydrolysis main fermenter should improve cultivation conditions microorganisms involved in complex substrates like lignocellulosic biomass (LCB) and, thus, digesters. However, relatively little is known about such two-stage processes. Here, we investigated agricultural AD over one year, focusing chemical technical parameters...
Abstract Phages are viruses that infect prokaryotes and can shape microbial communities by lysis, thus offering applications in various fields. However, challenges exist sampling, isolation, predicting host specificity of phages. A new workflow using biorthogonal non-canonical amino acid tagging (BONCAT) click chemistry (CC) allows combined analysis phages their hosts. Replication phage λ Escherichia coli was selected as a model for development. Specific labelling proteins with the...
One Health seeks to integrate and balance the health of humans, animals, environmental systems. These three spheres are intricately interconnected through microbiomes, which universally present exchange microbes genes, influencing not only human animal but also key environmental, agricultural, biotechnological processes. Preventing emergence pathogens as well monitoring controlling composition microbiomes microbial effectors including virulence factors, toxins, antibiotics, non-ribosomal...
A comprehensive understanding of microbial community dynamics is fundamental to the advancement environmental microbiology, human health, and biotechnology. Metaproteomics, defined as analysis all proteins present within a community, provides insights into these complex systems. Microbial adaptation activity depend an important extent on newly synthesized (nP), however, distinction between nP bulk challenging. The application BONCAT with click chemistry has demonstrated efficacy in...
Abstract Background The gut microbiome is an important contributor to the development and course of inflammatory bowel disease (IBD). While changes in composition were observed response IBD therapy using biologics, studies elucidating human microbial proteins pathways dependence on success are sparse. Methods Fecal samples a cohort patients collected before after 14 weeks treatment with three different biologics. Clinical activity scores used determine clinical remission. metaproteomes...
Abstract A comprehensive understanding of microbial community dynamics is fundamental to the advancement environmental microbiology, human health, and biotechnology. Metaproteomics, i.e. analysis all proteins in a community, provides insights into these complex systems. Microbial adaptation activity depend an important extent on newly synthesized (nP), however, distinction between nP bulk challenging. The application bioorthogonal non-canonical amino acid tagging (BONCAT) with click...
Abstract The effective operation, planning, and optimization of renewable energy production in anaerobic digestion (AD) plants relies on advanced process models, such as the Anaerobic Digestion Model No. 1 (ADM1). This study applies an ADM1-based model (ADM1da) to simulate a two-step digester industrial setting. data demonstrate that 2.6% methane is lost result open hydrolysis. Conversely, incorporation hydrolysis fermenter enhances by average 2.5%. Although ADM1-like models are widely...