A5072013020- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Hip and Femur Fractures
- Orthopedic Infections and Treatments
- interferon and immune responses
- Cytokine Signaling Pathways and Interactions
- Knee injuries and reconstruction techniques
- SARS-CoV-2 and COVID-19 Research
- Osteoarthritis Treatment and Mechanisms
- Clinical Nutrition and Gastroenterology
- Viral Infectious Diseases and Gene Expression in Insects
- Animal Virus Infections Studies
- Biochemical Analysis and Sensing Techniques
- Venous Thromboembolism Diagnosis and Management
- Acute Myocardial Infarction Research
- Asthma and respiratory diseases
- Infant Nutrition and Health
- Foot and Ankle Surgery
- Delphi Technique in Research
- Atrial Fibrillation Management and Outcomes
- Immune Response and Inflammation
- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Artificial Intelligence in Healthcare and Education
- Education Systems and Policy
Cleveland Clinic
2020-2024
Children's Hospital of Philadelphia
2019-2021
Orthopaedic Research Society
2021
Creative Commons
2021
University of Pennsylvania
2020
University of Cincinnati Medical Center
2002-2007
Sabin Vaccine Institute
2007
ABSTRACT The severe acute respiratory syndrome (SARS) epidemic was caused by the spread of a previously unrecognized infectious agent, SARS-associated coronavirus (SARS-CoV). Here we show that SARS-CoV could inhibit both virus- and interferon (IFN)-dependent signaling, two key steps antiviral response. We mapped strong inhibitory activity to nonstructural protein 1 (nsp1) expression nsp1 significantly inhibited activation all three virus-dependent signaling pathways. IFN-dependent decreasing...
Artificial intelligence and machine-learning analytics have gained extensive popularity in recent years due to their clinically relevant applications. A wide range of proof-of-concept studies demonstrated the ability these analyses personalize risk prediction, detect implant specifics from imaging, monitor assess patient movement recovery. Though applications are exciting could potentially influence practice, it is imperative understand when indicated where data derived from, prior investing...
This article was updated on May 1, 2024 because of a previous error, which discovered after the preliminary version posted online. The byline that had read "Ahmed K. Emara, MD 1 *, Ignacio Pasqualini, Alison Klika, MS , Melissa N. Orr, BS Pedro J. Rullán, Nicolas S. Piuzzi, and Cleveland Clinic Arthroplasty Group†" now reads Yuxuan Jin, Group†".
Determination of the appropriate post-discharge disposition after total hip (THA) and knee (TKA) arthroplasty is a challenging multidisciplinary decision. Algorithms used to guide this decision have been administered both preoperatively postoperatively. The purpose study was simultaneously evaluate predictive ability 2 such tools-the Predicting Location Arthroplasty Nomogram (PLAN) postoperatively Activity Measure for Post-Acute Care (AM-PAC) "6-Clicks" basic mobility tools-in accurately...
Background: Pain and function, as reflected by patient-reported outcome measures (PROMs), can influence improvement after total knee arthroplasty (TKA) reflect the extent of patient access to orthopaedic surgical care. We aimed (1) categorize patients according pain function PROM phenotypes, (2) identify characteristics associated with poor preoperative (3) assess relationships between baseline phenotypes. Methods: A prospective cohort 14,079 TKAs was enrolled. Demographics, comorbidities,...
The interferon‐β promoter has been studied extensively as a model system for combinatorial transcriptional regulation. In virus‐infected cells the transcription factors ATF‐2, c‐Jun, interferon regulatory factor (IRF)‐3, IRF‐7 and NF‐κB, coactivators p300/CBP play critical roles in activation of this other promoters. It remains unclear, however, why most combinations AP‐1, IRF Rel proteins fail to activate gene. Here we have explored how different IRFs may cooperate with transcription. First...
Virus infection results in the activation of a set cellular genes involved host antiviral defense. IRF‐3 has been identified as critical transcription factor this process. The mechanism is not fully elucidated, yet it involves conformational change triggered by virus‐dependent phosphorylation its C‐terminus. This leads to nuclear accumulation, DNA binding and transcriptional transactivation. Here we show that two distinct sets Ser/Thr residues IRF‐3, on phosphorylation, synergize...
Revision total hip arthroplasty (THA) is a challenging procedure that burdens the healthcare system. Despite being associated with worse outcomes relative to its primary counterpart, postoperative mortality after revision THA remains ill-defined. The present study aimed (1) establish overall 30-day rate and (2) explore stratified by age, comorbidity burden, aseptic versus septic failure.
Total knee arthroplasty (TKA) is the sole disease-modifying intervention for end-stage osteoarthritis. However, temporal trends and stratification of age patient demographics pain function levels at which surgeons perform TKA have not been characterized. The present investigation aimed to analyze preoperative functional patient-reported outcomes measures (PROMs) over past 5 years when stratifying demographics. A prospective cohort all patients who underwent primary elective between January...
Abstract: A shift toward a value-driven health-care model has made prospective collection of patient-reported outcome measures (PROMs) inextricably tied to measuring the success orthopaedic surgery and patient satisfaction. While progress been in optimizing utilization PROM data, including establishing appropriate PROMs for procedure determining clinical importance unique tools, if these are not accurately analyzed reported, proportion patients who do reach thresholds may go unnoticed....
In revision total knee arthroplasty (TKA), information regarding perioperative mortality risk is essential for careful decision-making. This study aimed to elucidate the (1) overall 30-day rate and (2) stratified by age, comorbidity, septic vs aseptic failure after TKA.The American College of Surgeons National Surgical Quality Improvement Program was reviewed all patients undergoing TKA from 2011 2019. A 32,354 who underwent were identified categorized as (n = 115) or mortality-free 32,239)....
Epithelial solitary chemosensory cell (tuft cell) bitter taste signal transduction occurs through G protein coupled receptors and calcium-dependent signaling pathways. Type II cells, which utilize the same pathways, may also cyclic adenosine monophosphate (cAMP) as an independent messenger in addition to calcium.In this work we utilized specific pharmacologic inhibitors interrogate short circuit current (Isc) of polarized nasal epithelial cells mounted Ussing chambers assess...
Endoplasmic reticulum protein of 29 kDa (ERp29) is a thioredoxin-homologous endoplasmic (ER) that regulates the biogenesis cystic fibrosis transmembrane conductance regulator (CFTR) and epithelial sodium channel (ENaC). ERp29 may promote ENaC cleavage increased open probability by directing to Golgi via coat complex II (COP II) during biogenesis. We hypothesized ERp29's C-terminal KEEL ER retention motif, KDEL variant associated with less robust retention, strongly influences its regulation...
Background and AimsThe Extra-Uterine Environment for Neonatal Development (EXTEND) aims to avoid the complications of prematurity, such as NEC. Our goal was determine if bowel development occurs normally in EXTEND-supported lambs, with specific emphasis on markers immaturity associated NEC.MethodsWe compared terminal ileum from 17 pre-term lambs supported EXTEND 2- 4 weeks age-matched fetal that developed utero. We evaluated morphology, epithelial integrity maturation, enteric nervous system...
In Brief Mini-abstract: Patient-reported outcome measures are increasingly important in the era of value-based healthcare. We use example total joint arthroplasty to demonstrate how current reporting may hide poorer outcomes. There is thus a need for standardized approach patient-reported measure tied clinically relevant thresholds.