A5009740816- Liver Disease Diagnosis and Treatment
- Estrogen and related hormone effects
- Vitamin D Research Studies
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Medical History and Innovations
- Retinoids in leukemia and cellular processes
- Colorectal Cancer Screening and Detection
- COVID-19 and healthcare impacts
- Cancer and Skin Lesions
- Global Cancer Incidence and Screening
- Neurology and Historical Studies
- Genetic factors in colorectal cancer
- Viral-associated cancers and disorders
- Pancreatitis Pathology and Treatment
- Colorectal Cancer Surgical Treatments
- Pancreatic function and diabetes
- Gastric Cancer Management and Outcomes
- History of Medicine Studies
- RNA modifications and cancer
- Vascular Malformations and Hemangiomas
- Autoimmune and Inflammatory Disorders Research
- Adrenal and Paraganglionic Tumors
- AI in cancer detection
- Cytomegalovirus and herpesvirus research
Newcastle upon Tyne Hospitals NHS Foundation Trust
2015-2023
Royal Victoria Infirmary
2013-2022
Newcastle University
2016-2022
Freeman Hospital
2021
National and Kapodistrian University of Athens
2017
James Cook University Hospital
2009-2010
University Hospital of North Durham
2009
Heinrich Heine University Düsseldorf
2000-2001
Introduction Non-alcoholic fatty liver disease (NAFLD) is a common worldwide. Experimental and small clinical trials have demonstrated that angiotensin II blockers (ARB) may be anti-fibrotic in the liver. The aim of this randomised controlled trial was to assess whether treatment with Losartan for 96 weeks slowed, halted or reversed progression fibrosis patients non-alcoholic steatohepatitis (NASH). Methods Double-blind randomised-controlled 50 mg once day versus placebo histological...
Colorectal cancers (CRCs) detected through the NHS Bowel Cancer Screening Programme (BCSP) have been shown to a more favourable outcome compared non-screen-detected cancers. The aim was identify whether this solely due earlier stage shift of these cancers, or other factors were involved. A combination regional CRC registry (Northern Audit Group) and BCSP database used screen-detected interval (diagnosed after negative faecal occult blood test, before next screening round), diagnosed between...
The vitamin D receptor (VDR) is the nuclear for 1, 25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)] that acts as a ligand-dependent transcription factor via combined contact with coactivator proteins (steroid coactivator-1, transcriptional intermediary 2, and associated 3) specific DNA binding sites [vitamin response elements (VDREs)]. Ligand-mediated conformational changes of VDR contribute to key mechanisms in this hormone signaling process. 1alpha,25(OH)(2)D(3), MC1288...
A 25-carboxylic ester analog of 1α,25-dihydroxyvitamin D<sub>3</sub>[1α,25(OH)<sub>2</sub>D<sub>3</sub>], ZK159222 (compound 1), was recently described as a novel type antagonist 1α,25(OH)<sub>2</sub>D<sub>3</sub> signaling. In this study five derivatives compound 1 (compounds 2–6) were selected because their sensitivity in facilitating complex formation between the receptor (VDR) and retinoid X on response element that comparable to natural hormone (0.2–0.9 nM). Most reacted typical...
Abstract Background Molecular characterisation of hepatocellular carcinoma (HCC) is central to the development novel therapeutic strategies for disease. We have previously demonstrated mutagenic consequences Long-Interspersed Nuclear Element-1 (LINE1s/L1) retrotransposition. However, role L1 in HCC, besides somatic mutagenesis, not well understood. Methods analysed expression TCGA-HCC RNAseq dataset ( n = 372) and explored potential relationships between clinical features. The findings were...
The nuclear hormone 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3) acts through the transcription factor vitamin D receptor (VDR) via combined contact with retinoid X (RXR), coactivator proteins, and specific DNA binding sites (VDREs). Ligand-mediated conformational changes of VDR are core molecular switch 1α,25(OH)2D3 signalling. Studying interaction analogues this should allow characterization their potential selective biological profile. A analogue two side chains (Ro27-2310 or Gemini) was...
Normothermic machine perfusion (NMP) provides a platform for drug-delivery. However, pharmacological considerations therapeutics delivered during NMP are scarcely reported. We aimed to demonstrate the ability of as testing, using drug which increases metabolism (2,4-dinitrophenol; DNP) an example therapeutic.
In molecular diagnosis of infectious diseases often more than 1 pathogen has to be considered. As a consequence, series labor-intensive and time-consuming polymerase chain reaction (PCR) approaches specific for different putative pathogens have carried out. To speed up diagnosis, we established low-density microarray simultaneous detection diverse causing disease such as granulomatous lymphadenitis. Nucleic acids from formalin-fixed, paraffin-embedded tissues 68 patients with lymphadenitis...
Hepatitis C virus (HCV) is a common cause of hepatocellular carcinoma (HCC). The activation and mutagenic consequences L1 retrotransposons in virus-associated-HCC have been documented. However, the direct influence HCV upon elements unclear, focus present study. transcript expression was evaluated publicly available liver tissue RNA-seq dataset from patients with chronic hepatitis (CHC), as well healthy controls. significantly higher CHC than L1orf1p (a encoded protein) observed six out 11...
We measured biomarkers of tumour growth and vascularity in interval screen-detected colorectal cancers (CRCs) the English Bowel Cancer Screening Programme order to determine whether rapid might contribute CRC (a diagnosed between a negative guaiac stool test next scheduled screening episode). Formalin-fixed, paraffin-embedded sections from 71 CRCs (screen-detected 43, 28) underwent immunohistochemistry for CD31 Ki-67, measure microvessel density (MVD) proliferation index (PI), respectively,...
Abstract The pancreas is particularly sensitive to acute cellular stress, but this has been difficult evaluate using light microscopy. Pancreatic ischaemia associated with deceased organ donation negatively impacts whole‐organ and isolated‐islet transplantation outcomes. Post‐mortem changes have also hampered accurate interpretation of ante‐mortem pancreatic pathology. A rigorous histological scoring system accurately quantifying required experimentally innovations in preservation increase...
Background: Although liver normothermic machine perfusion is increasingly used clinically, there are few reports of complications or adverse events. Many centers perform NMP to viability test suboptimal grafts, often for prolonged periods. In addition, several researchers investigating as a drug delivery platform, which usually necessitates otherwise non-viable grafts. We describe two instances methaemoglobinaemia during livers. Methods: The eight human livers rejected transplantation...