A5103192916- Hepatitis B Virus Studies
- Hepatitis C virus research
- HIV/AIDS drug development and treatment
- Genetic factors in colorectal cancer
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Cell Adhesion Molecules Research
- Glycosylation and Glycoproteins Research
- Ovarian cancer diagnosis and treatment
- Pharmaceutical studies and practices
- Multiple and Secondary Primary Cancers
- Blood groups and transfusion
- Cholangiocarcinoma and Gallbladder Cancer Studies
- HIV Research and Treatment
- Inflammatory Bowel Disease
- Monoclonal and Polyclonal Antibodies Research
- S100 Proteins and Annexins
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Gastrointestinal disorders and treatments
- Cancer Mechanisms and Therapy
- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Ferroptosis and cancer prognosis
Qingdao University
2024
Qingdao Municipal Hospital
2024
Third People's Hospital of Huzhou
2022-2024
Zhejiang Provincial People's Hospital
2021-2024
Luye Pharma (China)
2019-2022
Second People's Hospital of NanTong
2021
Nantong University
2021
Gilead Sciences (United States)
2009
Cornell University
1993-1994
Human neutrophils (PMN) respond to tumor necrosis factor (TNF) by releasing their granules, reorganizing cytoskeleton, and massively secreting hydrogen peroxide. This response is dependent on adhesion extracellular matrix proteins expression of CD11b/CD18 integrins (Nathan, C., S. Srimal, C. Farber, E. Sanchez, L. Kabbash, A. Asch, J. Gailit, D. Wright. 1989. Cell Biol. 109:1341-1349). We investigated the role tyrosine phosphorylation in PMN TNF. adherent protein-coated surfaces but not...
Pyrimidinol carboxylic acids were designed as inhibitors of HIV-1 RNase H function. These molecules can coordinate to two divalent metal ions in the active site. Inhibition enzymatic activity was measured a biochemical assay, but no antiviral effect observed. Binding demonstrated via solid state structure isolated p15-Ec domain RT showing inhibitor and Mn(II) bound
The focal adhesion protein paxillin undergoes tyrosine phosphorylation in response to signals mediated by integrins, neuropeptides and oncogene products, possibly via activation of the adhesion-associated kinase, p125FAK. In present work, tumor necrosis factor-alpha (TNF) stimulated human neutrophils. Cell participation beta 2 integrin CD18 were necessary, but not sufficient, for response. Adherent neutrophils also phosphorylated phorbol ester, formylmethionyl-leucyl-phenylalanine opsonized...
The timely identification of individuals at high risk for peptic ulcers (PUs) is vital in preventing gastrointestinal bleeding after antiplatelet therapy. This study was designed to determine PU factors and develop a assessment model detection the general Chinese population. In prospective dataset, clinical data from undergoing gastroscopic evaluation between April 2019 May 2022 were recorded. PUs defined as mucosal defects exceeding 5 mm confirmed via gastroscopy. Participants categorized...
Abstract Background Pradefovir is a liver-targeted prodrug of adefovir, nucleoside/nucleotide analogue with antiviral activity against hepatitis B virus (HBV) DNA polymerase. This phase 2 study compared the efficacy and safety oral pradefovir (30, 45, 60, or 75 mg) versus tenofovir disoproxil fumarate (TDF; 300 aimed to identify most appropriate dose for forthcoming 3 study. Methods Treatment-naive experienced (not on treatment >6 months) patients chronic were eligible. Results A...
Background. Little is known about the efficacy and safety of single-balloon enteroscopy (SBE) in patients with Peutz−Jeghers syndrome (PJS). The aim this study was to assess SBE for treatment small bowel polyps PJS. Methods. We conducted a single-center observational study, which included all diagnosed PJS who underwent polypectomy between January 2018 March 2021. Complete defined as absence ≥10 mm after resection. clinical records were retrospectively reviewed. Results. 102 (including 40...
BACKGROUND: PPM1G, a member of the serine/threonine protease family, dephosphorylates various proteins and may be involved in cancer development. The role mechanism PPM1G HCC still needs to verified. OBJECTIVE: This study aims explore occurrence, development prognosis HCC. METHODS: Using bioinformatics (UALCAN, cBioPortal, Linkedomics, STRING GSEA) analyze expression mRNA HCC, its clinical relevance possible signaling pathways. protein was determined by immunohistochemistry 311 cases...
Objective: Hepenofovir, a novel hepatic targeting prodrug of tenofovir, has been developed for the treatment chronic hepatitis B (CHB). This is first-in-human study to evaluate pharmacokinetics (PK) and tolerability single multiple escalating doses hepenofovir in healthy Chinese subjects. Methods: phase Ia included two parts: double-blinded, randomized, placebo-controlled single-ascending-dose (SAD) (25-200 mg) under fasted conditions comprising food-effect investigation (200...
Background: Little is known about the efficacy and safety of single balloon enteroscopy (SBE) in patients with Peutz-Jeghers syndrome (PJS). The aim this study was to assess SBE for treatment small bowel polyps PJS. Methods: We conducted a center observational study, which included all diagnosed PJS who underwent polypectomy between January 2018 March 2021. Complete defined as absence polyps≥20mm after resection. clinical records were retrospectively reviewed. Results: 102 (including 40 men...
Background: Captisol®-enabled-fosphenytoin sodium (CE-fosphenytoin sodium) injection is a modified formulation of fosphenytoin sodium. Objective: We aim to compare the intravenous and intramuscular bioavailability safety between CE-fosphenytoin sodium, (Cerebyx®), phenytoin (intravenous only). Methods: In pivotal study 1, 54 subjects were divided into three sequence groups that receive 250 mg equivalent (PE), (T), or (R1) (R2) in period 1. After 14-day washout period, 36 randomized two...
Abstract Background and purpose: Quickly screening of high-risk peptic ulcer (PU) is great significance to avoid gastrointestinal bleeding after antiplatelet therapy. In this study, we hoped find a fast less invasive method for PU screening. Methods: The clinical data health examined population who were admitted taking gastroscopic assessment in our hospital, from January 2019 June 2020, was prospectively collected. defined as gastric or duodenal mucosal defect >5mm diameter on...